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Open access peer-reviewed Edited Volume

Gene Therapy Applications

The aim of our book is to provide a detailed discussion of gene therapy application in human diseases. The book brings together major approaches: (1) Gene therapy in blood and vascular system, (2) Gene therapy in orthopedics, (3) Gene therapy in genitourinary system, (4) Gene therapy in other diseases. This source will make clinicians and researchers comfortable with the potential and problems of gene therapy application.

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Gene Therapy ApplicationsEdited by Chunsheng Kang

Published: August 23rd 2011

DOI: 10.5772/1013

ISBN: 978-953-307-541-9

eBook (PDF) ISBN: 978-953-51-6453-1

Copyright year: 2011

Books open for chapter submissions

59435 Total Chapter Downloads

9 Crossref Citations

31 Web of Science Citations

36 Dimensions Citations


Open access peer-reviewed

1. Gene Therapy with Non-Viral Vectors For Critical Limb Ischemia: From Bench to Bedside

By Erich Vinicius De Paula


Open access peer-reviewed

2. Cell-Based Gene Therapies and Stem Cells for Regeneration of Ischemic Tissues

By Rosalinda Madonna and Raffaele De Caterina


Open access peer-reviewed

3. Establishment of Conditional Transgenic Mice Model with Cavernous Hemangioma Using the Tet-On System

By Jia Wei Zheng


Open access peer-reviewed

4. Potential Gene Therapy: Intravenous Administration of Phagocytes Transfected Ex Vivo with FGF4 DNA/Biodegradable Gelatin Complex Promotes Angiogenesis in Animal Model of Myocardial Ischemia/Reperfusion Injury

By Toru Shizuma, Chiharu Tanaka, Hidezo Mori and Naoto Fukuyam


Open access peer-reviewed

5. Approaches in Gene Therapy of Cancer and Cardiovascular Diseases

By Gardlik Roman, Dovinova Ima and Chan Julie Y.H.


Open access peer-reviewed

6. Rescue of Familial Hypertrophic Cardiomyopathy by Altering Sarcomeric Exposure and Response to Calcium

By David F. Wieczorek and Beata M. Wolska


Open access peer-reviewed

7. Gene Therapy in Cardiovascular Disease

By José Luis Reyes-Juárez and Angel Zarain-Herzberg


Open access peer-reviewed

8. Potential Gene Therapy for Intervertebral Disc Degeneration

By Kotaro Nishida, Koichiro Maeno, Kakutani Kenichiro, Takashi Yurube, and Masahiro Kurosaka


Open access peer-reviewed

9. Conditioning and Scaffolding of Chondrocytes: Smart Steps Towards Osteoarthritis Gene Therapy

By Muhammad Farooq Rai, Annemarie Lang, Matthias Sieber and Michael F.G. Schmidt


Open access peer-reviewed

10. Gene Therapy Challenges in Arthritis

By Denys Anne, Thiolat Allan, Boissier Marie-Christophe and Bessis Natacha


Open access peer-reviewed

11. Gene Therapy Outcomes in Experimental Models of Inflammatory Arthritis

By Charles J. Malemud


Open access peer-reviewed

12. Gene Therapy Applications for Fracture Repair

By Cassandra A. Strohbach, Donna D. Strong and Charles H. Rundle


Open access peer-reviewed

13. Ex Vivo Gene Therapy for Spinal Fusion

By Takashi Kaito, Stephanie S. Ngo and Jeffrey C. Wang


Open access peer-reviewed

14. Gene Therapy in Urology

By Ratha Mahendran, Sin Mun Tham and Kesavan Esuvaranathan


Open access peer-reviewed

15. Delivery Methods to Target RNAs in the Kidney

By Csaba Révész and Péter Hamar


Open access peer-reviewed

16. Therapeutic Potential of Gene Transfer to Testis; Myth or Reality?

By Yoshiyuki Kojima, Kentaro Mizuno, Yukihiro Umemoto, Shoichi Sasaki, Yutaro Hayashi and Kenjiro Kohri


Open access peer-reviewed

17. Quality of Life of Patients with Hormone Refractory Prostate Cancer After Gene Therapy

By Akinobu Gotoh, Shuji Terao and Toshiro Shirakawa


Open access peer-reviewed

18. Fetal Gene Therapy

By Christopher Porada and Graça Almeida-Porada


Open access peer-reviewed

19. Genetic Addiction Risk Score (GARS): Testing For Polygenetic Predisposition and Risk to Reward Deficiency Syndrome (RDS)

By Kenneth Blum, Frank Fornari, B.William Downs, Roger L. Waite, John Giordano, Andrew Smolen, Yijun Lui, Jai Tain, Neil Majmundar and Eric R. Braverman


Open access peer-reviewed

20. Current and Future Biological Treatments in Inflammatory Bowel Disease

By Jesus K. Yamamoto-Furusho


Open access peer-reviewed

21. Gene Therapy for Alpha-1-Antitrypsin Deficiency Diseases

By Parveen Salahuddin


Open access peer-reviewed

22. Recent Developments in Gene Therapy Research Targeted to Cerebellar Disorders

By Hirokazu Hirai and Akira Iizuka


Open access peer-reviewed

23. Role of Gene Therapy in the Management of Unilateral Vocal Fold Paralysis

By Kevin Fung


Open access peer-reviewed

24. Fluorescence Cross-Correlation Spectroscopy for Real-Time Monitoring of Exogenous DNA Behavior in Living Cells

By Akira Sasaki and Masataka Kinjo


Open access peer-reviewed

25. Alpha-1 Antitrypsin Deficiency: Recent Developments in Gene Therapy Research

By Catherine M. Greene and Noel G. McElvaney


Open access peer-reviewed

26. Critical Stages in the Development of the First Targeted, Injectable Molecular-Genetic Medicine for Cancer

By Erlinda M. Gordon and Frederick L. Hall


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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