Open access peer-reviewed Edited Volume

Non-Viral Gene Therapy

This book focuses on recent advancement of gene delivery systems research. With the multidisciplinary contribution in gene delivery, the book covers several aspects in the gene therapy development: various gene delivery systems, methods to enhance delivery, materials with modification and multifunction for the tumor or tissue targeting. This book will help molecular biologists gain a basic knowledge of gene delivery vehicles, while drug delivery scientist will better understand DNA, molecular biology, and DNA manipulation.

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Non-Viral Gene TherapyEdited by Xubo Yuan

Published: November 7th 2011

DOI: 10.5772/1010

ISBN: 978-953-307-538-9

eBook (PDF) ISBN: 978-953-51-4408-3

Copyright year: 2011

Books open for chapter submissions

72160 Total Chapter Downloads

22 Crossref Citations

66 Web of Science Citations

75 Dimensions Citations


Open access peer-reviewed

1. Non-Viral Gene Therapy Vectors Carrying Genomic Constructs

By George Kotzamanis, Hassan Abdulrazzak, Athanassios Kotsinas and Vassilis G. Gorgoulis


Open access peer-reviewed

2. Non-Viral Delivery Systems in Gene Therapy and Vaccine Development

By Azam Bolhassani and Sima Rafati


Open access peer-reviewed

3. Gene Delivery Systems: Tailoring Vectors to Reach Specific Tissues

By Carlos J. Alméciga-Díaz, Rocio Cuaspa and Luis A. Barrera


Open access peer-reviewed

4. Investigation of Transfection Barriers Involved in Non-Viral Nanoparticulate Gene Delivery in Different Cell Lines

By Stefanie Häfele and Regine Süss


Open access peer-reviewed

5. The Mechanical Agitation Method of Gene Transfer for Ex-Vivo Gene Therapy

By Hea-Jong Chung, Hyun-Seo Lee, Hyeon-Jin Kim and Seong-Tshool Hong


Open access peer-reviewed

6. Gene Therapy of Some Genetic Diseases by Transferring Normal Human Genomic DNA into Somatic Cells and Stem Cells from Patients

By Liting Song


Open access peer-reviewed

7. Non Viral Gene Transfer Approaches for Lysosomal Storage Disorders

By Ursula Matte, Guilherme Baldo and Roberto Giugliani


Open access peer-reviewed

8. DNA Vaccination by Electrogene Transfer

By Pieranna Chiarella, Vito Michele Fazio and Emanuela Signori


Open access peer-reviewed

9. Gene Delivery with Ultrasound and Microbubbles

By Evan Unger and Terry Matsunaga


Open access peer-reviewed

10. Ultrasound-Mediated Gene Delivery

By Carol H. Miao and Andrew A. Brayman


Open access peer-reviewed

11. Polyamine – Lipid Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer Activity

By Takehisa Dewa, Tomohiro Asai, Naoto Oku and Mamoru Nango


Open access peer-reviewed

12. Technological Aspects of Scalable Processes for the Production of Functional Liposomes for Gene Therapy

By Julia E. Trevisan, Leide P. Cavalcanti, Cristiano L. P. Oliveira, Lucimara G. de La Torre and Maria Helena A. Santana


Open access peer-reviewed

13. Cationic Liposomes in Different Structural Levels for Gene Delivery

By Yinan Zhao, Defu Zhi and Shubiao Zhang


Open access peer-reviewed

14. Neutral Liposomes and DNA Transfection

By Michela Pisani, Giovanna Mobbili and Paolo Bruni


Open access peer-reviewed

15. Non-Viral Gene Delivery Systems Based on Cholesterol Cationic Lipids: Structure-Activity Relationships

By Michael A. Maslov and Marina A. Zenkova


Open access peer-reviewed

16. Polycation-Mediated Gene Delivery: The Physicochemical Aspects Governing the Process

By Manuel Alatorre-Meda, Eustolia Rodríguez-Velázquez and Julio R. Rodríguez


Open access peer-reviewed

17. Medical Polymer-Based Gene Therapy

By Hu-Lin Jiang, You-Kyoung Kim, Chong-Su Cho and Myung-Haing Cho


Open access peer-reviewed

18. Chitosan and Its Modifications: Are They Possible Vehicles for Gene Therapy?

By Ureporn Kedjarune-Leggat and Peter A. Leggat


Open access peer-reviewed

19. Chitosan-DNA/siRNA Nanoparticles for Gene Therapy

By Qin Shi, Marcio J. Tiera, Xiaoling Zhang, Kerong Dai, Mohamed Benderdour and Julio C. Fernandes


Open access peer-reviewed

20. Toxicity of Polymeric-Based Non-Viral Vector Systems for Pulmonary siRNA Application

By Andrea Beyerle, Thomas Kissel and Tobias Stoeger


Open access peer-reviewed

21. PAMAM Dendrimer as Potential Delivery System for Combined Chemotherapeutic and MicroRNA-21 Gene Therapy

By Xuan Zhou, Yu Ren, Xubo Yuan, Peiyu Pu and Chunsheng Kang


Open access peer-reviewed

22. Nanomedicine Based Approaches to Cancer Diagonsis and Therapy

By Roderick A. Slavcev, Shawn Wettig and Tranum Kaur


Open access peer-reviewed

23. Toxicogenomics of Nonviral Cationic Gene Delivery Nanosystems

By Yadollah Omidi, Vala Kafil and Jaleh Barar


Open access peer-reviewed

24. Nano-Particulate Calcium Phosphate as a Gene Delivery System

By Babak Mostaghaci, Arash Hanifi, Brigitta Loretz and Claus-Michael Lehr


Open access peer-reviewed

25. Modular Multifunctional Protein Vectors for Gene Therapy

By Hugo Peluffo


Open access peer-reviewed

26. Peptides as Promising Non-Viral Vectors for Gene Therapy

By Wei Yang Seow and Andrew JT George


Open access peer-reviewed

27. Binding of Protein-Functionalized Entities onto Synthetic Vesicles

By Federica De Persiis, Ramon Pons, Carlotta Pucci, Franco Tardani and Camillo La Mesa


Open access peer-reviewed

28. Targeting TRAIL Receptors with Genetically- Engineered CD34+ Hematopoietic Stem Cells

By Carmelo Carlo-Stella, Arianna Giacomini, Silvia L. Locatelli, Cristiana Lavazza and Alessandro M. Gianni


Open access peer-reviewed

29. Pyrrole-Imidazole Polyamides for Gene Therapy: Bioanalytical Methods and Pharmacokinetics

By Tomonori Kamei, Takahiko Aoyama, Takahiro Ueno, Noboru Fukuda, Hiroki Nagase and Yoshiaki Matsumoto


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI
  • BIOSIS Previews

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