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Open access peer-reviewed Edited Volume

Targets in Gene Therapy

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Targets in Gene Therapy
Targets in Gene Therapy Edited by Yongping You

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Academic Editor

Yongping You
Yongping You

Published23 August 2011

Doi10.5772/1012

ISBN978-953-307-540-2

eBook (PDF) ISBN978-953-51-6454-8

Copyright year2011

Number of pages448

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Table of Contents

Open access  chapters

1. Choosing Targets for Gene Therapy

By Karina J. Matissek, Ruben R. Bender, James R. Davis and Carol S. Lim

6,623
2. Gene Modulation by Peptide Nucleic Acids (PNAs) Targeting microRNAs (miRs)

By Rosangela Marchelli, Roberto Corradini, Alex Manicardi, Stefano Sforza, Tullia Tedeschi, Enrica Fabbri, Monica Borgatti, Nicoletta Bianchi and Roberto Gambari

2,876
3
3. Effective Transgene Constructs to Enhance Gene Therapy with Trichostatin A

By Hideki Hayashi, Yuhua Ma, Tomoko Kohno, Masayuki Igarashi, Kiyoshi Yasui, Koon Jiew Chua,Yoshinao Kubo, Motoki Ishibashi, Ryuji Urae, Shin Irie and Toshifumi Matsuyama

2,366
2
4. Suicide Gene Therapy by Herpes Simplex Virus-1 Thymidine Kinase (HSV-TK)

By Dilip Dey and Gregory R.D. Evans

6,333
6
5. Translational Challenges for Hepatocyte-Directed Gene Transfer

By Stephanie C. Gordts, Eline Van Craeyveld, Frank Jacobs and Bart De Geest

2,137
6. Physiologically-Regulated Expression Vectors for Gene Therapy

By Olivia Hibbitt and Richard Wade-Martins

2,093
7. PLP-Dependent Enzymes: a Potent Therapeutic Approach for Cancer and Cardiovascular Diseases

By Ashraf S. El-Sayed and Ahmed A. Shindia

5,151
4
8. Improvement of FasL Gene Therapy In Vitro by Fusing the FasL to Del1 Protein Domains

By Hisataka Kitano, Atsushi Mamiya and Chiaki Hidai

1,737
1
9. Feasibility of BMP-2 Gene Therapy Using an Ultra-Fine Needle

By Kenji Osawa, Yasunori Okubo, Kazumasa Nakao, Noriaki Koyama and Kazuhisa Bessho

1,916
1
10. Current Strategies for Cancer Gene Therapy

By Yufang Zuo, Xiaofang Ying, Hui Wang, Wen Ye, Xiangqi Meng, Hongyan Yu, Yi Zhou, Wuguo Deng and Wenlin Huang

2,852
11. Gene Therapy Strategy for Tumour Hypoxia

By Hiroshi Harada

2,888
12. Gene Therapy of Glioblastoma: Anti – Gene Anti IGF-I Strategy

By Jerzy Trojan

2,384
13. Mechanism of Hypoxia-Inducible Factor-1alpha Over- Expression and Molecular-Target Therapy for Hepatocellular Carcinoma

By Dengfu Yao, Min Yao, Shanshan Li and Zhizhen Dong

2,598
14. Cancer Gene Therapy via NKG2D and FAS Pathways

By Yanzhang Wei, Jinhua Li and Hari Shankar R. Kotturi

2,549
1
15. Emergence of IFN-lambda as a Potential Antitumor Agent

By Ahmed Lasfar and Karine A. Cohen-Solal

3,610
1
16. Intramuscular IL-12 Electrogene Therapy for Treatment of Spontaneous Canine Tumors

By Maja Cemazar, Gregor Sersa, Darja Pavlin and Natasa Tozon

1,905
6
17. Gene Therapy Targets and the Role of Pharmacogenomics in Heart Failure

By Dimosthenis Lykouras, Christodoulos Flordellis and Dimitrios Dougenis

2,251
18. Gene Therapy of the Heart through Targeting Non-Cardiac Cells

By Guro Valen

2,126
1
19. Transplantation of Sendai Viral Angiopoietin-1-Modified Mesenchymal Stem Cells for Ischemic Heart Disease

By Jianhua Huang, Huishan Wang and Hirofumi Hamada

1,985
20. Using Factor VII in Hemophilia Gene Therapy

By Bahram Kazemi

3,679
21. The Different Effects of TGF-β1, VEGF and PDGF on the Remodeling of Anterior Cruciate Ligament Graft

By Changlong Yu, Lin Lin and Xuelei Wei

1,953
1
22. Different ex Vivo and Direct in Vivo DNA Administration Strategies for Growth Hormone Gene Therapy in Dwarf Animals

By Cibele Nunes Peroni, Nélio Alessandro de Jesus Oliveira, Claudia Regina Cecchi, Eliza Higuti and Paolo Bartolini

2,155
23. Protection from Lethal Cell Death in Cecal Ligation and Puncture-Induced Sepsis Mouse Model by In Vivo Delivery of FADD siRNA

By Yuichi Hattori and Naoyuki Matsuda

2,116
24. Muscle-Targeted Gene Therapy of Charcot Marie-Tooth Disease is Dependent on Muscle Activity

By Stephan Klossner, Marie-Noëlle Giraud, Sara Sancho Oliver, David Vaughan and Martin Flück

2,647

IMPACT OF THIS BOOK AND ITS CHAPTERS

68,918 Total Chapter Downloads

8,329 Total Chapter Views

30 Crossref Citations

44 Web of Science Citations

63 Dimensions Citations

18 Altmetric Score

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