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Open access peer-reviewed Edited Volume

Targets in Gene Therapy

This book aims at providing an up-to-date report to cover key aspects of existing problems in the emerging field of targets in gene therapy. With the contributions in various disciplines of gene therapy, the book brings together major approaches: Target Strategy in Gene Therapy, Gene Therapy of Cancer and Gene Therapy of Other Diseases. This source enables clinicians and researchers to select and effectively utilize new translational approaches in gene therapy and analyze the developments in target strategy in gene therapy.

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Targets in Gene TherapyEdited by Yongping You

Published: August 23rd 2011

DOI: 10.5772/1012

ISBN: 978-953-307-540-2

eBook (PDF) ISBN: 978-953-51-6454-8

Copyright year: 2011

Books open for chapter submissions

62240 Total Chapter Downloads

20 Crossref Citations

35 Web of Science Citations

45 Dimensions Citations


Open access peer-reviewed

1. Choosing Targets for Gene Therapy

By Karina J. Matissek, Ruben R. Bender, James R. Davis and Carol S. Lim


Open access peer-reviewed

2. Gene Modulation by Peptide Nucleic Acids (PNAs) Targeting microRNAs (miRs)

By Rosangela Marchelli, Roberto Corradini, Alex Manicardi, Stefano Sforza, Tullia Tedeschi, Enrica Fabbri, Monica Borgatti, Nicoletta Bianchi and Roberto Gambari


Open access peer-reviewed

3. Effective Transgene Constructs to Enhance Gene Therapy with Trichostatin A

By Hideki Hayashi, Yuhua Ma, Tomoko Kohno, Masayuki Igarashi, Kiyoshi Yasui, Koon Jiew Chua,Yoshinao Kubo, Motoki Ishibashi, Ryuji Urae, Shin Irie and Toshifumi Matsuyama


Open access peer-reviewed

4. Suicide Gene Therapy by Herpes Simplex Virus-1 Thymidine Kinase (HSV-TK)

By Dilip Dey and Gregory R.D. Evans


Open access peer-reviewed

5. Translational Challenges for Hepatocyte-Directed Gene Transfer

By Stephanie C. Gordts, Eline Van Craeyveld, Frank Jacobs and Bart De Geest


Open access peer-reviewed

6. Physiologically-Regulated Expression Vectors for Gene Therapy

By Olivia Hibbitt and Richard Wade-Martins


Open access peer-reviewed

7. PLP-Dependent Enzymes: a Potent Therapeutic Approach for Cancer and Cardiovascular Diseases

By Ashraf S. El-Sayed and Ahmed A. Shindia


Open access peer-reviewed

8. Improvement of FasL Gene Therapy In Vitro by Fusing the FasL to Del1 Protein Domains

By Hisataka Kitano, Atsushi Mamiya and Chiaki Hidai


Open access peer-reviewed

9. Feasibility of BMP-2 Gene Therapy Using an Ultra-Fine Needle

By Kenji Osawa, Yasunori Okubo, Kazumasa Nakao, Noriaki Koyama and Kazuhisa Bessho


Open access peer-reviewed

10. Current Strategies for Cancer Gene Therapy

By Yufang Zuo, Xiaofang Ying, Hui Wang, Wen Ye, Xiangqi Meng, Hongyan Yu, Yi Zhou, Wuguo Deng and Wenlin Huang


Open access peer-reviewed

11. Gene Therapy Strategy for Tumour Hypoxia

By Hiroshi Harada


Open access peer-reviewed

12. Gene Therapy of Glioblastoma: Anti – Gene Anti IGF-I Strategy

By Jerzy Trojan


Open access peer-reviewed

13. Mechanism of Hypoxia-Inducible Factor-1alpha Over- Expression and Molecular-Target Therapy for Hepatocellular Carcinoma

By Dengfu Yao, Min Yao, Shanshan Li and Zhizhen Dong


Open access peer-reviewed

14. Cancer Gene Therapy via NKG2D and FAS Pathways

By Yanzhang Wei, Jinhua Li and Hari Shankar R. Kotturi


Open access peer-reviewed

15. Emergence of IFN-lambda as a Potential Antitumor Agent

By Ahmed Lasfar and Karine A. Cohen-Solal


Open access peer-reviewed

16. Intramuscular IL-12 Electrogene Therapy for Treatment of Spontaneous Canine Tumors

By Maja Cemazar, Gregor Sersa, Darja Pavlin and Natasa Tozon


Open access peer-reviewed

17. Gene Therapy Targets and the Role of Pharmacogenomics in Heart Failure

By Dimosthenis Lykouras, Christodoulos Flordellis and Dimitrios Dougenis


Open access peer-reviewed

18. Gene Therapy of the Heart through Targeting Non-Cardiac Cells

By Guro Valen


Open access peer-reviewed

19. Transplantation of Sendai Viral Angiopoietin-1-Modified Mesenchymal Stem Cells for Ischemic Heart Disease

By Jianhua Huang, Huishan Wang and Hirofumi Hamada


Open access peer-reviewed

20. Using Factor VII in Hemophilia Gene Therapy

By Bahram Kazemi


Open access peer-reviewed

21. The Different Effects of TGF-β1, VEGF and PDGF on the Remodeling of Anterior Cruciate Ligament Graft

By Changlong Yu, Lin Lin and Xuelei Wei


Open access peer-reviewed

22. Different ex Vivo and Direct in Vivo DNA Administration Strategies for Growth Hormone Gene Therapy in Dwarf Animals

By Cibele Nunes Peroni, Nélio Alessandro de Jesus Oliveira, Claudia Regina Cecchi, Eliza Higuti and Paolo Bartolini


Open access peer-reviewed

23. Protection from Lethal Cell Death in Cecal Ligation and Puncture-Induced Sepsis Mouse Model by In Vivo Delivery of FADD siRNA

By Yuichi Hattori and Naoyuki Matsuda


Open access peer-reviewed

24. Muscle-Targeted Gene Therapy of Charcot Marie-Tooth Disease is Dependent on Muscle Activity

By Stephan Klossner, Marie-Noëlle Giraud, Sara Sancho Oliver, David Vaughan and Martin Flück


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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