Open access peer-reviewed Edited Volume

Viral Gene Therapy

Edited by Ke Xu

Tianjin Medical University General Hospital

The development of technologies that allow targeting of specific cells has progressed substantially in recent years for several types of vectors, particularly viral vectors, which have been used in 70% of gene therapy clinical trials. Particular viruses have been selected as gene delivery vehicles because of their capacities to carry foreign genes and their ability to efficiently deliver these genes associated with efficient gene expression. This book is designed to present the most recent advances in viral gene therapy

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Viral Gene TherapyEdited by Ke Xu

Published: July 20th 2011

DOI: 10.5772/1011

ISBN: 978-953-307-539-6

eBook (PDF) ISBN: 978-953-51-6438-8

Copyright year: 2011

Books open for chapter submissions

73059 Total Chapter Downloads

21 Crossref Citations

34 Web of Science Citations

49 Dimensions Citations


Open access peer-reviewed

1. Retroviral Vectors in Gene Therapy: Mechanism of Integration, Successes in Gene Therapy Trials, Emerging Problems and Potential Solutions

By Ahmed F. Salem, Johanna Smith, Michael Lisanti and Rene Daniel


Open access peer-reviewed

2. Production of Retroviral and Lentiviral Gene Therapy Vectors: Challenges in the Manufacturing of Lipid Enveloped Virus

By Ana Rodrigues, Paula M. Alves and Ana Coroadinha


Open access peer-reviewed

3. Surface Modification of Retroviral Vectors for Gene Therapy

By Christoph Metzner and John Dangerfield


Open access peer-reviewed

4. The Glucocorticoid Receptor in Retroviral Infection

By Brian Fouty and Victor Solodushko


Open access peer-reviewed

5. Adenoviral Vectors: Potential and Challenges as a Gene Delivery System

By Suresh K. Mittal, AnneMarie Swaim and Yadvinder S. Ahi


Open access peer-reviewed

6. Adenovirus-Based Gene Therapy for Cancer

By Changqing Su


Open access peer-reviewed

7. Recombinant Adenovirus Vector Infection of Human Dendritic Cells

By William Adams and Karin Loré


Open access peer-reviewed

8. Harnessing the Potential of Adenovirus Vectored Vaccines

By Peter Johannes Holst and Allan Randrup Thomsen


Open access peer-reviewed

9. Adeno Associated Virus Mediated β-Thalassemia Gene Therapy

By Mengqun Tan, Xiaojuan Sun, Zhenqing Liu, Liujiang Song, Jing Tian, Xiaolin Yin and Xinhua Zhang


Open access peer-reviewed

10. Comparison of AAV Serotypes for Gene Delivery to Dopaminergic Neurons in the Substantia Nigra

By Joanna Korecka, Marijn Schouten, Ruben Eggers, Ayse Ulusoy, Koen Bossers and Joost Verhaagen


Open access peer-reviewed

11. Progress and Challenges in AAV-Mediated Gene Therapy for Duchenne Muscular Dystrophy

By Shin'Ichi Takeda and Takashi Okada


Open access peer-reviewed

12. Viral Vectors as Tools to Investigate the Role of Dysregulated Proteins in Nervous System Pathologies: the Case of Acquired Motor Neuropathies

By Carmen R. Sunico and Bernardo Moreno-Lopez


Open access peer-reviewed

13. Designing Lentiviral Gene Vectors

By Oleg Tolmachov, Tanya Tolmachova and Faisal A. Al-Allaf


Open access peer-reviewed

14. Gene Regulatable Lentiviral Vector System

By Yasutsugu Suzuki and Youichi Suzuki


Open access peer-reviewed

15. Dendritic Cells and Lentiviral Vectors: Mapping the Way to Successful Immuno Gene Therapy

By Cleo Goyvaerts, Grazyna Kochan, David Escors and Karine Breckpot


Open access peer-reviewed

16. Development and Application of HIV Vectors Pseudotyped with HIV Envelopes

By Koichi Miyake and Takashi Shimada


Open access peer-reviewed

17. Highly Efficient Retrograde Gene Transfer for Genetic Treatment of Neurological Diseases

By Shigeki Kato, Masahito Kuramochi, Kenta Kobayashi, Ken-Ichi Inoue, Masahiko Takada and Kazuto Kobayashi


Open access peer-reviewed

18. Herpes Simplex Type 1 for Use in Cancer Gene Therapy: Looking Backward to Move Forward

By Breanne Cuddington and Karen Mossman


Open access peer-reviewed

19. Gene Therapy of Melanoma Using Inactivated Sendai Virus Envelope Vector (HVJ-E) with Intrinsic Anti-Tumor Activities

By Yasufumi Kaneda, Eiji Kiyohara, Toshihiro Nakajima and Toshimitsu Itai


Open access peer-reviewed

20. Pharmacokinetic Study of Viral Vectors for Gene Therapy: Progress and Challenges

By Xianxing Xu, Yang Jingwen and Cheng Yuanguo


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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