Open access peer-reviewed Edited Volume

Novel Aspects in Acute Lymphoblastic Leukemia

Edited by Stefan Faderl

The University of Texas MD Anderson Cancer Center, United States of America

Acute lymphoblastic leukemia (ALL) has turned from a universally fatal to a highly curable disease in little more than four decades. Even though differences in outcome continue to exist between children and adults, intense efforts are under way to overcome this discrepancy and improve the prognosis of adult patients as well. This exemplary progress in ALL therapy has been possible by the combination of an increasingly better understanding of the biology of the disease, availability of a range of effective drugs, and astute designs and relentless executions of many clinical trials. ALL is a complex disease requiring complex therapy. Whereas this book cannot provide a comprehensive review of every one of its many facets, the chapters from many investigators from around the world nevertheless cover a number of relevant topics: aspects of the epidemiology of ALL in Hispanics, ophthalmologic manifestations of ALL, overviews of current therapy and drug-resistance mechanisms, novel biological pathways and targets, new drugs in development, and long-term consequences of CNS prophylaxis and therapy. The publishers and editor therefore hope that the prospective readers will find enough insight and information for their own endeavors.

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Novel Aspects in Acute Lymphoblastic LeukemiaEdited by Stefan Faderl

Published: November 16th 2011

DOI: 10.5772/1050

ISBN: 978-953-307-753-6

eBook (PDF) ISBN: 978-953-51-6573-6

Copyright year: 2011

Books open for chapter submissions

34755 Total Chapter Downloads

7 Crossref Citations

16 Web of Science Citations

23 Dimensions Citations


Open access peer-reviewed

1. Childhood Acute Leukemias in Hispanic Population: Differences by Age Peak and Immunophenotype

By Juan Manuel Mejía-Aranguré, María Luisa Pérez-Saldivar, Rosana Pelayo-Camacho, Ezequiel Fuentes-Pananá, Carolina Bekker-Mendez, Abigail Morales-Sánchez, David Aldebarán Duarte-Rodríguez and Arturo Fajardo-Gutiérrez


Open access peer-reviewed

2. Natural Killer Cell Leukemia: Diagnosis, Pathogenesis and Treatment

By Shoko Kobayashi


Open access peer-reviewed

3. Ophthalmological Manifestations in Acute Lymphoblastic Leukemia

By Javier Mateo, Francisco J. Ascaso, Esther Núñez, Carlos Peiro, Gonzalo González and José A. Cristóbal


Open access peer-reviewed

4. Acute Lymphoblastic Leukemia: What Have We Learned About the Effects of This Disease and Its Treatment on the Nervous System?

By Van Huynh, Leonard Sender and Daniela A. Bota


Open access peer-reviewed

5. Treatment of Pediatric Acute Lymphoblastic Leukemia and Recent Advances

By Tai-Tsung Chang and Pei-Chin Lin


Open access peer-reviewed

6. Cellular Therapy of ALL

By Casey A. Moffa, Cyrus Khan and John Lister


Open access peer-reviewed

7. Multidrug Resistance Mechanism of Acute Lymphoblastic Leukemia

By Zhaoliang Su, Haitao Zhu, Yanfang Liu, Hongyan Yuan, Jingping Yin and Huaxi Xu


Open access peer-reviewed

8. Novel Therapeutic Targets in ALL Therapy

By Roman Crazzolara


Open access peer-reviewed

9. Aberrant Proliferative and Apoptotic Pathways in Acute Lymphoblastic Leukemia (ALL): Molecular Therapies to Overcome Chemo-Resistance

By Agostino Tafuri et, Michele Milella, Stefano Iacovelli, Fabiana De Cave, Chiara Gregorj, Paola Bergamo, Andrea Miele, Roberto Licchetta, Marina Konopleva, James A. McCubrey, Alberto M. Martelli, Robin Foà, Maria Teresa Petrucci and Maria Rosaria Ricciardi


Open access peer-reviewed

10. The Role of PAX5 in ALL

By Grazia Fazio, Andrea Biondi and Giovanni Cazzaniga


Open access peer-reviewed

11. p53 as a Therapeutic Target in T-ALL

By Irene Riz, Wenjing Yang, Weiqun Peng and Robert G. Hawley


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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