Open access peer-reviewed Edited Volume


Updates and New Insights


Hematology has constantly been advancing in parallel with technological developments that have expanded our understanding of the phenotypic, genetic, and molecular complexity and extreme clinical and biological heterogeneity of leukemias. This in turn allowed for developing more effective and less toxic alternative therapeutic approaches directed against critical molecular pathways in leukemic cells. The continuous and rather extensive influx of new information regarding the key features and underlying mechanisms as well as treatment options of leukemias requires frequent updating of this topic. The primary objective of this book is to provide the specialists involved in the clinical management and experimental research of acute and chronic leukemias with comprehensive and concise information on some important theoretical and practical developments in the biology, clinical assessment, and treatment of patients with leukemias; on specific clinical scenarios such as pregnancy or age; as well as on some molecular and pathogenetic mechanisms and their respective translation into novel therapies.

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LeukemiasUpdates and New InsightsEdited by Margarita Guenova

Published: November 11th 2015

DOI: 10.5772/59646

ISBN: 978-953-51-2202-9

eBook (PDF) ISBN: 978-953-51-7263-5

Copyright year: 2015

Books open for chapter submissions

13732 Total Chapter Downloads

6 Crossref Citations

2 Web of Science Citations

12 Dimensions Citations


Open access peer-reviewed

1. Pediatric High Risk Leukemia — Molecular Insights

By Chandrika Gowda, Olivia L. Francis, Yali Ding, Parveen Shiraz, Kimberly J. Payne and Sinisa Dovat


Open access peer-reviewed

2. Early T-cell Precursor Acute Lymphoblastic Leukemia – A Characteristic Neoplasm Presenting the Phenotype of Common Hematopoietic Progenitors for both Myeloid and Lymphoid Lineages

By Hiroko Tsunemine and Takayuki Takahashi


Open access peer-reviewed

3. Leukemia and Retroviral Disease

By Lorena Loarca, Neil Sullivan, Vanessa Pirrone and Brian Wigdahl


Open access peer-reviewed

4. Gene Mutations in Acute Myeloid Leukemia — Incidence, Prognostic Influence, and Association with Other Molecular Markers

By Olga Blau


Open access peer-reviewed

5. Update on Non-M3 Acute Myeloid Leukemia — Etiology, Classification, Risk Stratification, Emergencies, Complications, Disease in Special Circumstances and Current and Future Therapeutics

By Khalid Ahmed Al-Anazi


Open access peer-reviewed

6. Clofarabine and Adult Acute Myeloid Leukemia

By Branimir Spassov, Gueorgui Balatzenko, Georgi Mihaylov and Margarita Guenova


Open access peer-reviewed

7. Perspective on Therapeutic Strategies of Leukemia Treatment — Focus on Arsenic Compounds

By Bo Yuan, Noriyoshi Iriyama, Xiao-Mei Hu, Toshihiko Hirano, Hiroo Toyoda and Norio Takagi


Open access peer-reviewed

8. New Insights in Prognosis and Therapy of Chronic Lymphocytic Leukaemia

By Isabel González Gascón y Marín, María Hernández-Sánchez, Ana- Eugenia Rodríguez.Vicente and José-Ángel Hernández-Rivas


Open access peer-reviewed

9. Chronic Lymphocytic Leukemia — Microenvironment and B Cells

By Rositsa Vladimirova, Dora Popova, Elena Vikentieva and Margarita Guenova


Open access peer-reviewed

10. Zinc Oxide Nanoparticles and Photodynamic Therapy for the Treatment of B-chronic Lymphocytic Leukemia

By Sandra Loydover Peña Luengas, Gustavo H. Marin, Luis Rivera, Adrian Tarditti, Gustavo Roque and Eduardo Mansilla


Open access peer-reviewed

11. Update on Leukemia in Pregnancy

By Khalid Ahmed Al-Anazi


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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