Open access peer-reviewed Edited Volume

Tumor Angiogenesis

Edited by Sophia Ran

Northern Illinois University, United States of America

Tumor angiogenesis is the main process responsible for the formation of new blood vessels that promote tumor growth and metastasis. This process is driven by potent pro-angiogenic factors that are predominant in the tumor environment and are produced by both malignant cells and the host cells recruited to the tumor site. Tumor environment is characterized by the imbalance between pro-angiogenic and anti-angiogenic factors, which drives the construction of numerous but structurally defective vessels. These poorly perfused and abnormal vessels significantly contribute to the tumor pathology not only by supporting the expansion of the tumor mass but also by promoting chronic inflammation, enhancing thrombosis, impeding drug delivery, and disseminating tumor cells. These problems associated with tumor vasculature continue to attract great attention of scientists and clinicians interested in advancing the understanding of tumor biology and development of new drugs. This book complies a series of reviews that cover a broad spectrum of current topics related to the pathology of tumor blood vessels including mechanisms inducing new vessels, identification of new targets for inhibition of tumor angiogenesis, and potential clinical use of known and novel anti-angiogenic therapies. The book provides an update on tumor angiogenesis that could be useful for oncologists, cancer researchers and biologists with interests in vascular and endothelial cell behavior in the context of cancer.

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Tumor AngiogenesisEdited by Sophia Ran

Published: February 17th 2012

DOI: 10.5772/1336

ISBN: 978-953-51-0009-6

eBook (PDF) ISBN: 978-953-51-6795-2

Copyright year: 2012

Books open for chapter submissions

30808 Total Chapter Downloads

9 Crossref Citations

23 Web of Science Citations

20 Dimensions Citations


Open access peer-reviewed

1. Heparin-Like Drugs with Antiangiogenic Activity

By María Rosa Aguilar, Luis García-Fernández, Raquel Palao-Suay and Julio San Román


Open access peer-reviewed

2. Regulation of Angiogenesis in Human Cancer via Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2)

By Shanchun Guo, Laronna S. Colbert, Tanisha Z. McGlothen and Ruben R. Gonzalez-Perez


Open access peer-reviewed

3. The Effect of Chinese Herb on Tumor Angiogenesis by Inhibiting Vessel Endothelial Cells

By Jian Jin, Li-Ying Qiu, Hui Hua and Lei Feng


Open access peer-reviewed

4. Beyond VEGF: The NOTCH and ALK1 Signaling Pathways as Tumor Angiogenesis Targets

By Olivier Nolan-Stevaux and H. Toni Jun


Open access peer-reviewed

5. Platelet Regulation of Angiogenesis, Tumor Growth and Metastasis

By Jessica Cedervall and Anna-Karin Olsson


Open access peer-reviewed

6. Malignant Transformation in Skin is Associated with the Loss of T-Cadherin Expression in Human Keratinocytes and Heterogeneity in T-Cadherin Expression in Tumor Vasculature

By Kseniya Rubina, Veronika Sysoeva, Ekaterina Semina, Natalia Kalinina, Ekaterina Yurlova, Albina Khlebnikova and Vladimir Molochkov


Open access peer-reviewed

7. Modeling Tumor Angiogenesis in Zebrafish

By Massimo M. Santoro


Open access peer-reviewed

8. The Role of VEGF in the Process of Neovasculogenesis

By Aleksandra Sobczyńska-Rak


Open access peer-reviewed

9. Cancer Related Inflammation and Tumor Angiogenesis

By Ping Wu


Open access peer-reviewed

10. Infantile Hemangiomas: A Disease Model in the Study of Vascular Development, Aberrant Vasculogenesis and Angiogenesis

By Alvin Wong and June K. Wu


Open access peer-reviewed

11. MicroRNAs Regulation of Tumor Angiogenesis

By Munekazu Yamakuchi


Open access peer-reviewed

12. New Molecular Targets for Anti-Angiogenic Therapeutic Strategies

By Amanda G. Linkous and Eugenia M. Yazlovitskaya


Open access peer-reviewed

13. Molecular Mechanisms of Tumor Angiogenesis

By Kelly Burrell and Gelareh Zadeh


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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