Open access peer-reviewed Edited Volume

Acute Leukemia

The Scientist's Perspective and Challenge

Edited by Mariastefania Antica

Rudjer Boskovic Institute, Croatia

This book provides a comprehensive overview of he basic mechanisms underlying areas of acute leukemia, current advances, and future directions in management of this disease. The first section discusses the classification of acute leukemia, taking into account diagnoses dependent on techniques that are essential, and thankfully readily available, in the laboratory. The second section concerns recent advances in molecular biology, markers, receptors, and signaling molecules responsible for disease progression, diagnostics based on biochips and other molecular genetic analysis. These advances provide clinicians with important understanding and improved decision making towards the most suitable therapy for acute leukemia. Biochemical, structural, and genetic studies may bring a new era of epigenetic based drugs along with additional molecular targets that will form the basis for novel treatment strategies. Later in the book, pediatric acute leukemia is covered, emphasizing that children are not small adults when it comes to drug development. The last section is a collection of chapters about treatment, as chemotherapy-induced toxicity is still a significant clinical concern. The present challenge lies in reducing the frequency and seriousness of adverse effects while maintaining efficacy and avoiding over-treatment of patients.

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Acute LeukemiaThe Scientist's Perspective and ChallengeEdited by Mariastefania Antica

Published: December 22nd 2011

DOI: 10.5772/841

ISBN: 978-953-307-553-2

eBook (PDF) ISBN: 978-953-51-6617-7

Copyright year: 2011

Books open for chapter submissions

97045 Total Chapter Downloads

13 Crossref Citations

14 Web of Science Citations

31 Dimensions Citations


Open access peer-reviewed

1. Classification of Acute Leukemia

By Gamal Abdul-Hamid


Open access peer-reviewed

2. Diagnosis of Acute Leukemia in Under-Resourced Laboratories

By Abbas H. Abdulsalam


Open access peer-reviewed

3. The PI3K/PKB Signaling Module in Normal and Malignant Hematopoiesis

By Roel Polak and Miranda Buitenhuis


Open access peer-reviewed

4. Lymphocyte Commitment and Ikaros Transcription Factors

By Mariastefania Antica


Open access peer-reviewed

5. Epigenetics and Targeted Therapy in Acute Leukemia

By Xudong Ma, Shaohong Jiang, Yiqun Huang, Yong Zou, Ruiji Zheng and Liyun Xiao


Open access peer-reviewed

6. Molecular Markers for Risk Stratification in Adult Acute Myeloid Leukemia with Normal Cytogenetics

By Ota Fuchs


Open access peer-reviewed

7. Trafficking of Acute Leukemia Cells – Chemokine Receptor Pathways that Modulate Leukemia Cell Dissemination

By Seiji Fukuda, Chie Onishi and Louis M. Pelus


Open access peer-reviewed

8. Biochemistry of the Mixed Lineage Leukemia 1 (MLL1) Protein and Targeted Therapies for Associated Leukemia

By Venkatasubramanian Dharmarajan and Michael S. Cosgrove


Open access peer-reviewed

9. Diagnostics of Molecular Markers in Childhood Acute Leukaemia Using Biochips

By Tatyana Nasedkina, Yuliya Yatsenko, Olga Gra, Natalia Guseva, Elena Samochatova and Alexander Zasedatelev


Open access peer-reviewed

10. Pediatric Acute Myeloid Leukemia

By C. Michel Zwaan and Marry M. van den Heuvel-Eibrink


Open access peer-reviewed

11. Pediatric Natural Killer Cell Malignancy

By Yoshiko Hashii


Open access peer-reviewed

12. Leukemogenesis in Down Syndrome

By Lílian Barros Queiroz, Íris Ferrari, Cezar Martins de Sá, Juliana Forte Mazzeu, Isis Quezado Magalhães and Beatriz Dolabela de Lima


Open access peer-reviewed

13. Cord Blood Transplantation in Adults with Acute Leukemia

By Takaaki Konuma and Satoshi Takahashi


Open access peer-reviewed

14. Acute Lymphoblastic Leukemia in Adolescents and Young Adults

By Josep-Maria Ribera


Open access peer-reviewed

15. Evidence-Based Guided Interventions in Acute Leukemia

By Ron Ram, Liat Vidal, Ronit Gurion, Pia Raanani and Ofer Shpilberg


Open access peer-reviewed

16. Hematologic Malignancies in Pregnancy

By C. Vandenbriele, A. Vassou, G. Pentheroudakis, K. Van Calsteren and F. Amant


Open access peer-reviewed

17. Chemotherapy Toxicity in Patients with Acute Leukemia

By Jose Manuel Vagace and Guillermo Gervasini


Open access peer-reviewed

18. Vitamin D and Acute Myeloid Leukemia

By Hun Ju Lee, Candace S. Johnson, Donald Trump and Meir Wetzler


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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