Open access peer-reviewed Edited Volume

Myeloid Leukemia

Basic Mechanisms of Leukemogenesis


Utz Krug

University of Münster, Germany

The current book comprises a series of chapters from experts in the field of myeloid cell biology and myeloid leukemia pathogenesis. It is meant to provide reviews about current knowledge in the area of basic science of acute (AML) and chronic myeloid leukemia (CML) as well as original publications covering specific aspects of these important diseases. Covering the specifics of leukemia biology and pathogenesis by authors from different parts of the World, including America, Europe, Africa, and Asia, this book provides a colorful view on research activities in this field around the globe.

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Myeloid LeukemiaBasic Mechanisms of LeukemogenesisEdited by Steffen Koschmieder

Published: December 14th 2011

DOI: 10.5772/1245

ISBN: 978-953-307-789-5

eBook (PDF) ISBN: 978-953-51-6608-5

Copyright year: 2011

Books open for chapter submissions

56345 Total Chapter Downloads

11 Crossref Citations

19 Web of Science Citations

27 Dimensions Citations


Open access peer-reviewed

1. BCR-ABL Hits at Mitosis; Implications for Chromosomal Instability, Aneuploidy and Therapeutic Strategy

By Katarzyna Piwocka, Kamila Wolanin, Monika Kusio-Kobialka and Paulina Podszywalow-Bartnicka


Open access peer-reviewed

2. BCR/ABL1 Extra Fusions in Patients with Chronic Myeloid Leukaemia (CML)

By Maria Teresa Vargas


Open access peer-reviewed

3. Causative Factors Involved in Development of Resistance to Tyrosine Kinase Inhibition and Novel Strategies Designed to Override This Resistance

By Ellen Weisberg and James D. Griffin


Open access peer-reviewed

4. De Novo Acquisition of BCR-ABL Mutations for CML Acquired Resistance

By WenYong Chen, Hongfeng Yuan and Zhiqiang Wang


Open access peer-reviewed

5. Targeting the Chronic Myeloid Leukemia Stem Cell: A Paradigm for the Curative Treatment of Human Malignancies

By Adrian Woolfson and Xiaoyan Jiang


Open access peer-reviewed

6. The Proteasome as a Therapeutic Target in Chronic Myeloid Leukemia

By Ignacio Pérez-Roger and María Pilar Albero


Open access peer-reviewed

7. Ser/Thr Phosphatases: The New Frontier for Myeloid Leukemia Therapy?

By Amanda M. Smith, Kathryn G. Roberts and Nicole M. Verrills


Open access peer-reviewed

8. Role of JAK2 Beyond Myeloproliferative Neoplasms (MPNs): Rationale for Targeting the JAK-STAT Pathway in Other Hematological Malignancies and Solid Tumors

By Theresa M. McDevitt and Matthew V. Lorenzi


Open access peer-reviewed

9. Genetic Alterations and Their Clinical Implications in Acute Myeloid Leukemia

By Hsin-An Hou, Wen-Chien Chou and Hwei-Fang Tien


Open access peer-reviewed

10. Bone Marrow Microenvironment in the Pathogenesis of AML

By Olga Blau


Open access peer-reviewed

11. Distinct Inhibitory Effect of TGFβ on the Growth of Human Myeloid Leukemia Cells

By Xiao Tang Hu


Open access peer-reviewed

12. Novel Targets in Myelogenous Leukemia: The Id Family of Proteins

By Kimberly D. Klarmann, Ming Ji, Huajie Li, Ande Satyanarayana, Wonil Kim, Emily Bowers, Bjorg Gudmundsdottir and Jonathan R. Keller


Open access peer-reviewed

13. PU.1, a Versatile Transcription Factor and a Suppressor of Myeloid Leukemia

By Shinichiro Takahashi


Open access peer-reviewed

14. Vav1: A Key Player in Agonist-Induced Differentiation of Promyelocytes from Acute Myeloid Leukemia (APL)

By Valeria Bertagnolo, Federica Brugnoli and Silvano Capitani


Open access peer-reviewed

15. p15INK4b, a Tumor Suppressor in Acute Myeloid Leukemia

By Joanna Fares, Linda Wolff and Juraj Bies


Open access peer-reviewed

16. New Molecular Markers in Acute Myeloid Leukemia

By Silvia de la Iglesia Iñigo, María Teresa Gómez Casares, Carmen Elsa López Jorge, Jezabel López Brito and Pedro Martin Cabrera


Open access peer-reviewed

17. Analysis of Leukemogenic Gene Products in Hematopoietic Progenitor Cells

By Julia Schanda, Reinhard Henschler, Manuel Grez and Christian Wichmann


Open access peer-reviewed

18. Acute Promyelocytic Leukemia: A Model Disease for Targeted Cancer Therapy

By Emma Lång and Stig Ove Bøe


Open access peer-reviewed

19. The Association of the DNA Repair Genes with Acute Myeloid Leukemia: The Susceptibility and the Outcome After Therapy

By Claudia Bănescu, Carmen Duicu and Minodora Dobreanu


Open access peer-reviewed

20. Apoptosis and Apoptosis Modulators in Myeloid Leukemia

By Maha Abdullah and Zainina Seman


Open access peer-reviewed

21. Role of Signaling Pathways in Acute Myeloid Leukemia

By Maha Abdullah and Zainina Seman


Open access peer-reviewed

22. Epigenetic Changes Associated with Chromosomal Translocation in Leukemia

By Soraya Gutierrez, Amjad Javed, Janet Stein, Gary Stein, Sandra Nicovani, Valentina Fernandez, Ricardo Alarcon, Marcela Stuardo, Milka Martinez, Marcela Hinojosa and Boris Rebolledo-Jaramillo


Open access peer-reviewed

23. Myeloid Leukemia: A Molecular Focus on Etiology and Risk Within Africa

By Muntaser E. Ibrahim and Emad-Aldin I. Osman


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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