Stanley Shostak

University of Pittsburgh United States of America

For fifty years, I have studied the evolution of growth’s integration with form. Hydras’ ability to move excess cells into buds was my model for cancer’s ability to support metastasis (e.g., Vegetative reproduction by budding in Hydra: A perspective on tumors. Perspectives in Biology and Medicine, 20:545–68; 1977; “Hydra and cancer: Immortality and budding,” pp. 275-86 in C.J. Dawe, J.C. Harshbarger, S. Kondo, T. Sugimura, and S. Takayama, eds., Phyletic Approaches to Cancer. Tokyo: Sci. Soc. 1981). I have concentrated on the origins of stem cells (Symbiogenetic origins of cnidarian cnidocysts. Symbiosis, 19:1–29; 1995 [with V. Kolluri]; “Speculation on the Evolution of Stem Cells,” Breast Disease, 29:3–13; 2007–8) and have developed my ideas further in books (Evolution of Death: Why We Are Living Longer. Albany: SUNY Press; 2006; Becoming Immortal: Combining Cloning and Stem-Cell Therapy. Albany: SUNY Press; 2002; Evolution of Sameness and Difference: Perspectives on the Human Genome Project. Amsterdam: Harwood Academic Publishers, 1999; Death of Life: The Legacy of Molecular Biology. London: Macmillan, 1998).

Stanley Shostak

2books edited

1chapters authored

Latest work with IntechOpen by Stanley Shostak

Over the last thirty years, the foremost inspiration for research on metastasis, cancer recurrence, and increased resistance to chemo- and radiotherapy has been the notion of cancer stem cells.The twenty-eight chapters assembled in Cancer Stem Cells - The Cutting Edge summarize the work of cancer researchers and oncologists at leading universities and hospitals around the world on every aspect of cancer stem cells, from theory and models to specific applications (glioma), from laboratory research on signal pathways to clinical trials of bio-therapies using a host of devices, from solutions to laboratory problems to speculation on cancers' stem cells' evolution. Cancer stem cells may or may not be a subset of slowly dividing cancer cells that both disseminate cancers and defy oncotoxic drugs and radiation directed at rapidly dividing bulk cancer cells, but research on cancer stem cells has paid dividends for cancer prevention, detection, targeted treatment, and improved prognosis.

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