Open access peer-reviewed Edited Volume

Updates on Endoplasmic Reticulum

Gaia Favero

University of Brescia

Human anatomy researcher involved in crucial topics on morphology, anatomy, and molecular medicine - working on innovative approaches to aging-related pathopsychological processes at the University of Brescia.


Metabolism Aging Neurodegenerative Diseases Endoplasmic Reticulum Microscopy Metabolic Stress Ultrastructural Anatomy Cellular Stress Contactology Mitochondria Cellular Stress Endoplasmic Reticulum Response

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About the book

In eukaryotic cells, the endoplasmic reticulum is an organelle adjacent to the nuclear membrane. This organelle is essential for calcium homeostasis and lipid biosynthesis and protein assembly, folding, and post-translational modification. The interplay between the endoplasmic reticulum membrane and the outer mitochondrial membrane, called mitochondria-associated endoplasmic reticulum membranes (MAMs), permits a wide range of cellular activity, including the division and fusion of mitochondria and the dynamic passage of lipids, glycogen, and calcium ions.
It has been established that energy/nutrient depletion, calcium flux injury, or oxidative stress disrupt endoplasmic reticulum homeostasis and even induce accumulation of misfolded/unfolded proteins leading to endoplasmic reticulum stress. Under endoplasmic reticulum stress conditions, an adaptive mechanism of coordinated signaling pathways, defined unfolded protein response (UPR), is activated to return the endoplasmic reticulum to its healthy functioning state. The aging causes a decrease of the protective adaptive response of the UPR and an increase of the pro-apoptotic pathway together with endoplasmic reticulum ultrastructural injury. Controlling endoplasmic reticulum stress response, maintaining the appropriate endoplasmic reticulum ultrastructure and homeostasis, and retaining mitochondria interplay are crucial aspects for cellular health.

This book presents a comprehensive overview of endoplasmic reticulum, including, but not limited to, endoplasmic reticulum ultrastructural anatomy, MAMs, endoplasmic reticulum stress, and their implication in health and diseases. Additionally, identifying perturbations in the endoplasmic reticulum stress response could lead to early detection of age-related disease and may help develop therapeutic approaches.

Publishing process

Book initiated and editor appointed

Date completed: February 9th 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

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Approved chapters written in full and submitted

Deadline for full chapters: July 5th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: September 23rd 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: November 22nd 2022

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About the editor

Gaia Favero

University of Brescia

Dr. Gaia Favero is a prominent scientist in the field of life sciences. She is currently engaged as a researcher for the Scientific-Disciplinary Sector BIO/16 Human Anatomy at the Anatomy and Pathophysiology Division, Department of Clinical and Experimental Sciences, University of Brescia (Italy). Dr. Favero focuses on aging-related morphological dysfunctions as the prelude to various pathophysiological processes in her research programs. The central hypothesis is that natural antioxidants and, in particular, melatonin may act as molecular "switches" that modulate cells and tissues by suppressing, at various levels, oxidative stress and inflammatory signalling cascades. These research approaches represent powerful tools for developing innovative preventive strategies and identifying novel prognostic biomarkers for several diseases. The above-reported research activity determined more than 120 scientific publications and an h-index of 25.

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Book chapters authored 1

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