Miroslav Blumenberg

New York University Langone Medical Center United States of America

Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.

6books edited

5chapters authored

Latest work with IntechOpen by Miroslav Blumenberg

The recent breakthrough in microbial studies has applied next-generation sequencing (NGS), a massive omics analysis, to the composition and structure of microbial communities. NGS can identify microbes without the need for their cultivation. Their mere presence can be ascertained and often quantitated, and even their metabolic capabilities of microbial constituents predicted. This breakthrough led to an explosive growth in research on microbes. Many important advances have been made in human health-related studies. Indeed, gut microbial communities have been extensively analyzed and differences between healthy and diseased microbiomes have been determined. Studies of the effects of changes of diet, of antibiotic treatments, and of probiotics have been published. Specific attention has been devoted to human pathogens, their mechanisms of causing disease, and the potentials for their management and treatment. Microbiome studies of natural habitats, terrestrial and aquatic, have also benefited from NGS methodology. Increased understanding of the microbial communities has led to the use microbes as antagonists of pathogens, i.e. as treatments. Moreover, novel uses of microbes in industrial processes, either for synthesis of important compounds or for degradation and handling of waste, are being devised. In this volume, chapters dealing with the cutting-edge research in all these fields are presented.

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Microorganisms

Edited by Miroslav Blumenberg

Books edited

By Sidra Younis, Valeriia Shnayder and Miroslav Blumenberg

Bioinformatics is a research field that uses computer‐based tools to investigate life sciences questions employing “big data” results from large‐scale DNA sequencing, whole genomes, transcriptomes, metabolomes, populations, and biological systems, which can only be comprehensively viewed in silico. The epidermis was among the earliest targets of bioinformatics studies because it represents one of the most accessible targets for research. An additional advantage of working with the epidermis is that the sample can even be recovered using tape stripping, an easy, noninvasive protocol. Consequently, bioinformatics methods in the fields of skin biology and dermatology generated a fairly large volume of bioinformatics data, which led us to originate the term “skinomics.” Skinomics data are directed toward epidermal differentiation, malignancies, inflammation, allergens, and irritants, the effects of ultraviolet (UV) light, wound healing, the microbiome, stem cells, etc. Cultures of cutaneous cell types, keratinocytes, fibroblasts, melanocytes, etc., as well as skin from human volunteers and from animal models, have been extensively experimented on. Here, we review the development of the skinomics, its methodology, current achievements, and future potentials.

Part of the book: Bioinformatics

Introductory Chapter: A Short Primer on Human Skin Cancers

By Miroslav Blumenberg

Part of the book: Human Skin Cancer, Potential Biomarkers and Therapeutic Targets

Introductory Chapter: Melanin, a Versatile Guardian

By Miroslav Blumenberg

Part of the book: Melanin

Introductory Chapter: Keratins - What to Do with Too Much? What to Do with Too Little?

By Miroslav Blumenberg and Sidra Younis

Part of the book: Keratin

Introductory Chapter: Transcriptome Analysis

By Miroslav Blumenberg