Open access peer-reviewed Edited Volume


Edited by Miroslav Blumenberg

New York University Langone Medical Center

Keratin is the proteinaceous body covering layer produced by mammals, birds, fish, reptiles, and amphibians. Hair and wool, horns, claws, hooves, feathers, and scales are made of keratin. Keratin is insoluble in water and is resistant to proteolysis. Importantly, keratin is also the intracellular structural protein that protects living epithelial cells from mechanical damage or stress. The fundamental keratin functions are revealed in congenital human skin diseases caused by mutations in keratin genes, e.g., Epidermolysis bullosa simplex or Epidermolytic hyperkeratosis. Most keratin gene mutations have a dominant-negative effect disrupting the filamentous structure formation even from the natural allele, and leaving the cell with a deficient cytoskeleton. However, industrial scale meat production results in vast quantities of keratin byproduct. Processing this byproduct is, on the one hand a major challenge, and on the other hand, a potential for useful recycling and exploitation.

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KeratinEdited by Miroslav Blumenberg

Published: December 19th 2018

DOI: 10.5772/intechopen.73230

ISBN: 978-1-78984-805-2

Print ISBN: 978-1-78984-804-5

eBook (PDF) ISBN: 978-1-83881-727-5

Copyright year: 2018

Books open for chapter submissions

9709 Total Chapter Downloads

17 Crossref Citations

8 Web of Science Citations

36 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Keratins - What to Do with Too Much? What to Do with Too Little?

By Miroslav Blumenberg and Sidra Younis


Open access peer-reviewed

2. Regulation of Expression of Keratins and their Pathogenic Roles in Keratinopathies

By Mayumi Komine


Open access peer-reviewed

3. Glucocorticoid Receptor Signaling in Skin Barrier Function

By Lisa M. Sevilla and Paloma Pérez


Open access peer-reviewed

4. Neuroendocrine Controls of Keratin Expression in Human Skin

By Yuval Ramot and Ralf Paus


Open access peer-reviewed

5. Keratins in Skin Epidermal Development and Diseases

By Ling-juan Zhang


Open access peer-reviewed

6. Shape Memory Effect of Keratin Fibers

By Xueliang Xiao and Jin-lian Hu


Open access peer-reviewed

7. Human Hair as a Testing Substrate in the Era of Precision Medicine: Potential Role of ‘Omics-Based Approaches

By Henry Ademola Adeola, Jennifer Cathryn Van Wyk, Afolake Temitope Arowolo and Nonhlanhla Patience Khumalo


Open access peer-reviewed

8. Keratinaceous Wastes and Their Valorization through Keratinolytic Microorganisms

By Debananda Singh Ningthoujam, Keishing Tamreihao, Saikat Mukherjee, Rakhi Khunjamayum, Laishram Jaya Devi and Roshan Singh Asem


Open access peer-reviewed

9. Keratin Waste: The Biodegradable Polymers

By Tarun Kumar Kumawat, Anima Sharma, Vishnu Sharma and Subhash Chandra


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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