Advanced Understanding of Neurodegenerative Diseases

Raymond Chuen-Chung Chang

doi:10.5772/2451

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Open access peer-reviewed Edited volume

Advanced Understanding of Neurodegenerative Diseases

Edited by Raymond Chuen-Chung Chang

University of Hong Kong

Advanced Understanding of Neurodegenerative Diseases focuses on different types of diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies, Parkinson's disease, prion disease, motor neuron diseases such as multiple sclerosis and spinal muscular atrophy. This book provides a clear explanation of different neurodegenerative diseases with new concepts of understand the etiology, pathological mechanisms, drug screening methodology and new therapeutic interventions. Other chapters discuss how hormones and health food supplements affect disease progression of neurodegenerative diseases. From a more technical point of view, some chapters deal with the aggregation of prion proteins in prion diseases. An additional chapter to discuss application of stem cells. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.

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Advanced Understanding of Neurodegenerative DiseasesEdited by Raymond Chuen-Chung Chang

Published: December 16th 2011

DOI: 10.5772/2451

ISBN: 978-953-307-529-7

Books open for chapter submissions

41933 Total Chapter Downloads

6 Crossref Citations

13 Web of Science Citations

23 Dimensions Citations

chapters		Downloads
Open access peer-reviewed 1. Alzheimer's Disease: Definition, Molecular and Genetic Factors By Eva Babusikova, Andrea Evinova, Jana Jurecekova, Milos Jesenak and Dusan Dobrota		3536
Open access peer-reviewed 2. Evidence for an Infectious Etiology in Alzheimer’s Disease By Brian Balin, Christine Hammond, C. Scott Little, Denah Appelt and Susan Hingley		1867
Open access peer-reviewed 3. Amyloid Hypothesis and Alzheimer's Disease By Xiaqin Sun and Yan Zhang		2055
Open access peer-reviewed 4. Structure-Toxicity Relationships of Amyloid Peptide Oligomers By Patrick Walsh and Simon Sharpe		2371
Open access peer-reviewed 5. Disruption of Calcium Homeostasis in Alzheimer’s Disease: Role of Channel Formation by β Amyloid Protein By Masahiro Kawahara, Hironari Koyama, Susumu Ohkawara and Midori Megishi-Kato		2780
Open access peer-reviewed 6. Recent Developments in Molecular Changes Leading to Alzheimer’s Disease and Novel Therapeutic Approaches By Vijaya B. Kumar		1413
Open access peer-reviewed 7. Clinical Profile of Alzheimer’s Disease Non-Responder Patient By Alessandro Martorana, Roberta Semprini and Giacomo Koch		1835
Open access peer-reviewed 8. Construction of Drug Screening Cell Model and Application to New Compounds Interfering Production and Accumulation of Beta-Amyloid by Inhibiting Gamma-Secretase By Xiao-Ning Wang, Jie Yang, Ping-Yue Xu, Jie Chen, Dan Zhang, Yan Sun and Zhi-Ming Huang		1583
Open access peer-reviewed 9. Therapeutics of Alzheimer’s Disease By Marisol Herrera-Rivero and Gonzalo Emiliano Aranda-Abreu		1786
Open access peer-reviewed 10. Frontotemporal Lobar Degeneration By Johannes Schlachetzki		2053
Open access peer-reviewed 11. From Protein Tangles to Genetic Variants: The Central Role of Tau in Neurodegenerative Disease By Heike Julia Wobst and Richard Wade-Martins		1357
Open access peer-reviewed 12. Gut Hormones Restrict Neurodegeneration in Parkinson’s Disease By Jacqueline Bayliss, Romana Stark, Alex Reichenbach and Zane B. Andrews		2418
Open access peer-reviewed 13. Grape Secondary Metabolites – Benefits for Human Health By Teodora Dzhambazova, Violeta Kondakova, Ivan Tsvetkov and Rossitza Batchvarova		2401
Open access peer-reviewed 14. Computational Studies of the Structural Stability of Rabbit Prion Protein Compared to Human and Mouse Prion Proteins By Jiapu Zhang		1195
Open access peer-reviewed 15. The Effects of Trimethylamine N-Oxide on the Structural Stability of Prion Protein By Barbara Yang, Kuen-Hua You, Shing-Chuen Wang, Hau-Ren Chen and Cheng-I Lee		1293
Open access peer-reviewed 16. Modeling Spinal Muscular Atrophy in Mouse: A Disease of Splicing, Stability, and Timing By Thomas W. Bebee and Dawn S. Chandler		1739
Open access peer-reviewed 17. Wallerian Degeneration in Injury and Diseases: Concepts and Prevention By Bruno S. Mietto, Rodrigo M. Costa, Silmara V. de Lima, Sérgio T. Ferreira and Ana M. B. Martinez		3345
Open access peer-reviewed 18. Mesenchymal Stem Cell Therapy for Apoptosis After Spinal Cord Injury By Venkata Ramesh Dasari, Krishna Kumar Veeravalli, Jasti S. Rao, Dan Fassett and Dzung H. Dinh		1962
Open access peer-reviewed 19. Modelling Multiple Sclerosis In Vitro and the Influence of Activated Macrophages By E.J.F. Vereyken, C.D. Dijkstra and C.E. Teunissen		2780
Open access peer-reviewed 20. Amyotrophic Lateral Sclerosis By David S. Shin, Ashley J. Pratt, Elizabeth D. Getzoff and J. Jefferson P. Perry		2164

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