Open access peer-reviewed Edited Volume

Advanced Understanding of Neurodegenerative Diseases

Advanced Understanding of Neurodegenerative Diseases focuses on different types of diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies, Parkinson's disease, prion disease, motor neuron diseases such as multiple sclerosis and spinal muscular atrophy. This book provides a clear explanation of different neurodegenerative diseases with new concepts of understand the etiology, pathological mechanisms, drug screening methodology and new therapeutic interventions. Other chapters discuss how hormones and health food supplements affect disease progression of neurodegenerative diseases. From a more technical point of view, some chapters deal with the aggregation of prion proteins in prion diseases. An additional chapter to discuss application of stem cells. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.

Read more >Order hardcopy
Advanced Understanding of Neurodegenerative DiseasesEdited by Raymond Chuen-Chung Chang

Published: December 16th 2011

DOI: 10.5772/2451

ISBN: 978-953-307-529-7

eBook (PDF) ISBN: 978-953-51-6611-5

Copyright year: 2011

Books open for chapter submissions

54416 Total Chapter Downloads

14 Crossref Citations

17 Web of Science Citations

28 Dimensions Citations


Open access peer-reviewed

1. Alzheimer's Disease: Definition, Molecular and Genetic Factors

By Eva Babusikova, Andrea Evinova, Jana Jurecekova, Milos Jesenak and Dusan Dobrota


Open access peer-reviewed

2. Evidence for an Infectious Etiology in Alzheimer’s Disease

By Brian Balin, Christine Hammond, C. Scott Little, Denah Appelt and Susan Hingley


Open access peer-reviewed

3. Amyloid Hypothesis and Alzheimer's Disease

By Xiaqin Sun and Yan Zhang


Open access peer-reviewed

4. Structure-Toxicity Relationships of Amyloid Peptide Oligomers

By Patrick Walsh and Simon Sharpe


Open access peer-reviewed

5. Disruption of Calcium Homeostasis in Alzheimer’s Disease: Role of Channel Formation by β Amyloid Protein

By Masahiro Kawahara, Hironari Koyama, Susumu Ohkawara and Midori Megishi-Kato


Open access peer-reviewed

6. Recent Developments in Molecular Changes Leading to Alzheimer’s Disease and Novel Therapeutic Approaches

By Vijaya B. Kumar


Open access peer-reviewed

7. Clinical Profile of Alzheimer’s Disease Non-Responder Patient

By Alessandro Martorana, Roberta Semprini and Giacomo Koch


Open access peer-reviewed

8. Construction of Drug Screening Cell Model and Application to New Compounds Interfering Production and Accumulation of Beta-Amyloid by Inhibiting Gamma-Secretase

By Xiao-Ning Wang, Jie Yang, Ping-Yue Xu, Jie Chen, Dan Zhang, Yan Sun and Zhi-Ming Huang


Open access peer-reviewed

9. Therapeutics of Alzheimer’s Disease

By Marisol Herrera-Rivero and Gonzalo Emiliano Aranda-Abreu


Open access peer-reviewed

10. Frontotemporal Lobar Degeneration

By Johannes Schlachetzki


Open access peer-reviewed

11. From Protein Tangles to Genetic Variants: The Central Role of Tau in Neurodegenerative Disease

By Heike Julia Wobst and Richard Wade-Martins


Open access peer-reviewed

12. Gut Hormones Restrict Neurodegeneration in Parkinson’s Disease

By Jacqueline Bayliss, Romana Stark, Alex Reichenbach and Zane B. Andrews


Open access peer-reviewed

13. Grape Secondary Metabolites – Benefits for Human Health

By Teodora Dzhambazova, Violeta Kondakova, Ivan Tsvetkov and Rossitza Batchvarova


Open access peer-reviewed

14. Computational Studies of the Structural Stability of Rabbit Prion Protein Compared to Human and Mouse Prion Proteins

By Jiapu Zhang


Open access peer-reviewed

15. The Effects of Trimethylamine N-Oxide on the Structural Stability of Prion Protein

By Barbara Yang, Kuen-Hua You, Shing-Chuen Wang, Hau-Ren Chen and Cheng-I Lee


Open access peer-reviewed

16. Modeling Spinal Muscular Atrophy in Mouse: A Disease of Splicing, Stability, and Timing

By Thomas W. Bebee and Dawn S. Chandler


Open access peer-reviewed

17. Wallerian Degeneration in Injury and Diseases: Concepts and Prevention

By Bruno S. Mietto, Rodrigo M. Costa, Silmara V. de Lima, Sérgio T. Ferreira and Ana M. B. Martinez


Open access peer-reviewed

18. Mesenchymal Stem Cell Therapy for Apoptosis After Spinal Cord Injury

By Venkata Ramesh Dasari, Krishna Kumar Veeravalli, Jasti S. Rao, Dan Fassett and Dzung H. Dinh


Open access peer-reviewed

19. Modelling Multiple Sclerosis In Vitro and the Influence of Activated Macrophages

By E.J.F. Vereyken, C.D. Dijkstra and C.E. Teunissen


Open access peer-reviewed

20. Amyotrophic Lateral Sclerosis

By David S. Shin, Ashley J. Pratt, Elizabeth D. Getzoff and J. Jefferson P. Perry


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£139

Order now

Residents of European Union countries need to add a Book Value-Added Tax Rate based on their country of residence. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase