Open access peer-reviewed Edited Volume

Alzheimer's Disease

Challenges for the Future

Edited by Inga Zerr

Augusta University, United States of America

There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.

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Alzheimer's DiseaseChallenges for the FutureEdited by Inga Zerr

Published: July 1st 2015

DOI: 10.5772/58663

ISBN: 978-953-51-2137-4

eBook (PDF) ISBN: 978-953-51-7242-0

Copyright year: 2015

Books open for chapter submissions

20089 Total Chapter Downloads

15 Crossref Citations

19 Web of Science Citations

28 Dimensions Citations


Open access peer-reviewed

1. Epidemiology of Alzheimer's Disease with the Projection of Falls Among the Aged Population

By Aysegul Uludag, Sibel Cevizci and Ahmet Uludag


Open access peer-reviewed

2. The Cascade of Oxidative Stress and Tau Protein Autophagic Dysfunction in Alzheimer’s Disease

By Zhenzhen Liu, Peifu Li, Jiannan Wu, Yi Wang, Ping Li, Xinxin Hou, Qingling Zhang, Nannan Wei, Zhiquan Zhao, Huimin Liang and Jianshe Wei


Open access peer-reviewed

3. Neuroinflammation and Alteration of the Blood-Brain Barrier in Alzheimer´s Disease

By Luis Oskar Soto-Rojas, Fidel de la Cruz-López, Miguel Angel Ontiveros Torres, Amparo Viramontes-Pintos, María del Carmen Cárdenas-Aguayo, Marco A. Meraz-Ríos, Citlaltepetl Salinas-Lara, Benjamín Florán-Garduño and José Luna-Muñoz


Open access peer-reviewed

4. Metals Involvement in Alzheimer’s Disease — A Patho-Genetic View

By Carlo Salustri, Mariacristina Siotto, Serena Bucossi and Rosanna Squitti


Open access peer-reviewed

5. Lipids and Lipoproteins in Alzheimer’s Disease

By Sophie Stukas, Iva Kulic, Shahab Zareyan and Cheryl L. Wellington


Open access peer-reviewed

6. Free Cholesterol — A Double-Edge Sword in Alzheimer Disease

By José C. Fernández-Checa


Open access peer-reviewed

7. The Mevalonate Pathway in Alzheimer’s Disease — Cholesterol and Non-Sterol Isoprenoids

By Amany Mohamed, Kevan Smith and Elena Posse de Chaves


Open access peer-reviewed

8. Recent Progress in the Identification of Non-Invasive Biomarkers to Support the Diagnosis of Alzheimer’s Disease in Clinical Practice and to Assist Human Clinical Trials

By Francois Bernier, Pavan Kumar, Yoshiaki Sato and Yoshiya Oda


Open access peer-reviewed

9. New Frontiers in Alzheimer's Disease Diagnosis

By Franc Llorens, Sabine Nuhn, Christoph Peter, Inga Zerr and Katharina Stoeck


Open access peer-reviewed

10. Genetic, Biochemical and Histopathological Aspects of Familiar Alzheimer's Disease

By Genaro Gabriel Ortiz, Fermín P. Pacheco-Moisés, Erika D. González- Renovato, Luis Figuera, Miguel A. Macías-Islas, Mario Mireles- Ramírez, L. Javier Flores-Alvarado, Angélica Sánchez-López, Dhea G. Nuño-Penilla, Irma E. Velázquez- Brizuela, Juan P. Sánchez-Luna and Alfredo Célis de la Rosa


Open access peer-reviewed

11. Gait Pathway in Subcortical Vascular Dementia and in Alzheimer’s Disease

By Rita Moretti, Arianna Sartori, Beatrice Baso and Silvia Gazzin


Open access peer-reviewed

12. The Alzheimer’s Patient in the Emergency Department — Specificities of Care

By De Breucker Sandra, Pepersack Thierry and Bier Jean-Christophe


Open access peer-reviewed

13. Uncontrolled Sexual Behaviour in Dementia

By Susan van Hooren and Wim Waterink


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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