Open access peer-reviewed Edited Volume

Alzheimer's Disease Pathogenesis

Core Concepts, Shifting Paradigms and Therapeutic Targets

Edited by Suzanne De La Monte

Brown University, United States of America

Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.

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Alzheimer's Disease PathogenesisCore Concepts, Shifting Paradigms and Therapeutic TargetsEdited by Suzanne De La Monte

Published: September 12th 2011

DOI: 10.5772/951

ISBN: 978-953-307-690-4

eBook (PDF) ISBN: 978-953-51-4437-3

Copyright year: 2011

Books open for chapter submissions

69379 Total Chapter Downloads

14 Crossref Citations

39 Web of Science Citations

45 Dimensions Citations


Open access peer-reviewed

1. Alzheimer ́s Disease – The New Actors of an Old Drama

By Mario Álvarez Sánchez, Carlos A. Sánchez Catasús, Ivonne Pedroso Ibañez, Maria L. Bringas and Arnoldo Padrón Sánchez


Open access peer-reviewed

2. Pathophysiology of Late Onset Alzheimer Disease

By Ahmet Turan Isik and M. Refik Mas


Open access peer-reviewed

3. Expression and Cerebral Function of Amyloid Precursor Protein After Rat Traumatic Brain Injury

By Tatsuki Itoh, Motohiro Imano, Shozo Nishida, Masahiro Tsubaki, Shigeo Hashimoto, Akihiko Ito and Takao Satou


Open access peer-reviewed

4. Key Enzymes and Proteins in Amyloid-Beta Production and Clearance

By Cecília R A Santos, Isabel Cardoso and Isabel Gonçalves


Open access peer-reviewed

5. Transporters in the Blood-Brain Barrier

By Masaki Ueno, Toshitaka Nakagawa and Haruhiko Sakamoto


Open access peer-reviewed

6. Contribution of Multivesicular Bodies to the Prion-Like Propagation of Lesions in Alzheimer’s Disease

By Valérie Vingtdeux, Luc Buée and Nicolas Sergeant


Open access peer-reviewed

7. Pathological Stages of Abnormally Processed Tau Protein During Its Aggregation into Fibrillary Structures in Alzheimer’s Disease

By Francisco García-Sierra, Gustavo Basurto-Islas, Jaime Jarero-Basulto, Hugo C. Monroy-Ramírez, Francisco M. Torres Cruz, Hernán Cortés Callejas, Héctor M. Camarillo Rojas, Zdena Kristofikova, Daniela Ripova, José Luna-Muñoz, Raúl Mena, Lester I. Binder and Siddhartha Mondragón-Rodríguez


Open access peer-reviewed

8. Structure and Toxicity of the Prefibrillar Aggregation States of Beta Peptides in Alzheimer’s Disease

By Angelo Perico, Denise Galante and Cristina D’Arrigo


Open access peer-reviewed

9. Structural and Toxic Properties of Protein Aggregates: Towards a Molecular Understanding of Alzheimer's Disease

By Lei Wang and Silvia Campioni


Open access peer-reviewed

10. The Role of Glycogen Synthase Kinase-3 (GSK-3) in Alzheimer’s Disease

By Miguel Medina and Jesús Avila


Open access peer-reviewed

11. Pin1: A New Enzyme Pivotal for Protecting Against Alzheimer’s Disease

By Kazuhiro Nakamura, Suk Ling Ma and Kun Ping Lu


Open access peer-reviewed

12. Selectivity of Cell Signaling in the Neuronal Response Based on NGF Mutations and Peptidomimetics in the Treatment of Alzheimers Disease

By Kenneth E. Neet, Sidharth Mahapatra, Hrishikesh M. Mehta


Open access peer-reviewed

13. Advances in MicroRNAs and Alzheimer’s Disease Research

By Francesca Ruberti, Silvia Pezzola and Christian Barbato


Open access peer-reviewed

14. Role of Mitochondria in Alzheimer ́s Disease

By Genaro Genaro Gabriel Ortiz, Fermín Pacheco-Moisés, José de Jesús García-Trejo, Roció E. González-Castañeda, Miguel A. Macías-Islas, José A. Cruz-Ramos, Irma E. Velázquez-Brizuela, Elva D. Árias Merino and Alfredo Célis de la Rosa


Open access peer-reviewed

15. Oxidative Stress in Alzheimer’s Disease: Pathogenesis, Biomarkers and Therapy

By Alejandro Gella and Irene Bolea


Open access peer-reviewed

16. Impact of Oxidative - Nitrosative Stress on Cholinergic Presynaptic Function

By Stefanie A.G. Black and R. Jane Rylett


Open access peer-reviewed

17. Metals Involvement in Alzheimer’s Disease Pathogenesis

By Rosanna Squitti and Carlo Salustri


Open access peer-reviewed

18. Alzheimer’s Disease and Metal Contamination: Aspects on Genotoxicity

By P.D.L. Lima, M.C. Vasconcellos, R.C. Montenegro and R.R. Burbano


Open access peer-reviewed

19. Glucose Metabolism and Insulin Action in Alzheimer’s Disease Pathogenesis

By Domenico Bosco, Massimiliano Plastino, Antonio Spanò, Caterina Ermio and Antonietta Fava


Open access peer-reviewed

20. Insulin Resistance, Cognitive Impairment and Neurodegeneration: Roles of Nitrosamine Exposure, Diet and Lifestyles

By Suzanne de la Monte, Ming Tong and Jack R. Wands


Open access peer-reviewed

21. The Relations Between the Vitamins and Alzheimer Dementia

By Emel Koseoglu


Open access peer-reviewed

22. Hypotension in Subcortical Vascular Dementia, a New Risk Factor – Wasn’t It Hypertension?

By Rita Moretti, Francesca Esposito, Paola Torre, Rodolfo M. Antonello and Giuseppe Bellini


Open access peer-reviewed

23. Autophagy-Derived Alzheimer’s Pathogenesis

By Daijun Ling and Paul M. Salvaterra


Open access peer-reviewed

24. Plasmalogen Deficit: A New and Testable Hypothesis for the Etiology of Alzheimer’s Disease

By Paul L. Wood, M. Amin Khan, Rishikesh Mankidy, Tara Smith and Dayan B. Goodenowe


Open access peer-reviewed

25. Gangliosides as a Double-Edged Swordin Neurodegenerative Disease

By Akio Sekigawa, Masayo Fujita, Kazunari Sekiyama, Yoshiki Takamatsu, Jianshe Wei and Makoto Hashimoto


Open access peer-reviewed

26. Structure Based 3D-QSAR Studies on Cholinesterase Inhibitors

By Zaheer ul Haq and Reaz Uddin


Open access peer-reviewed

27. Tau Oligomers as Potential Drug Target for Alzheimer Disease (AD) Treatment

By Rakez Kayed


Open access peer-reviewed

28. In Silico Design of Preventive Drugs for Alzheimer’s Disease

By Arpita Yadav and Minakshi Sonker


Open access peer-reviewed

29. Protective Roles of the Incretin Hormones Glucagon-Like Peptide-1 and Glucose-Dependent Insolinotropic Polypeptide Hormones in Neurodegeneration

By Christian Hölscher


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI

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