Open access peer-reviewed Edited Volume

Neurodegenerative Diseases

Edited by Uday Kishore

Brunel University London

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.

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Neurodegenerative DiseasesEdited by Uday Kishore

Published: May 15th 2013

DOI: 10.5772/45957

ISBN: 978-953-51-1088-0

eBook (PDF) ISBN: 978-953-51-7146-1

Copyright year: 2013

Books open for chapter submissions

67607 Total Chapter Downloads

49 Crossref Citations

50 Web of Science Citations

106 Dimensions Citations


Open access peer-reviewed

1. Alzheimer’s Disease: A Clinical Perspective

By Weili Xu, Anna Marseglia, Camilla Ferrari and Hui-Xin Wang


Open access peer-reviewed

2. Late-Onset Alzheimer's Disease: Risk Factors, Clinical Diagnosis and the Search for Biomarkers

By Marisol Herrera-Rivero


Open access peer-reviewed

3. Role of Protein Aggregation in Neurodegenerative Diseases

By Yusuf Tutar, Aykut Özgür and Lütfi Tutar


Open access peer-reviewed

4. Role of Oxidative Stress in Aβ Animal Model of Alzheimer's Disease: Vicious Circle of Apoptosis, Nitric Oxide and Age

By Ferihan Cetin


Open access peer-reviewed

5. Alterations of Mitochondria and Golgi Apparatus Are Related to Synaptic Pathology in Alzheimer's Disease

By Stavros J. Baloyannis


Open access peer-reviewed

6. Caspases in Alzheimer’s Disease

By Yan Zhang


Open access peer-reviewed

7. Brain Reserve Regulators in Alzheimer’s Disease

By Ivana Delalle


Open access peer-reviewed

8. Cholesterol and Alzheimer's Disease

By Iuliana Nicola-Antoniu


Open access peer-reviewed

9. Emerging Therapeutic Strategies in Alzheimer's Disease

By Tomohiro Chiba


Open access peer-reviewed

10. Dropping the BACE: Beta Secretase (BACE1) as an Alzheimer’s Disease Intervention Target

By Justin Read and Cenk Suphioglu


Open access peer-reviewed

11. QSAR Analysis of Purine-Type and Propafenone-Type Substrates of P-Glycoprotein Targeting β-Amyloid Clearance

By Jie Yang and Jie Chen


Open access peer-reviewed

12. Therapeutic Interventions in Alzheimer Disease

By Analava Mitra and Baishakhi Dey


Open access peer-reviewed

13. Other Dementias

By Abhishek Shastri, Domenico Marco Bonifati and Uday Kishore


Open access peer-reviewed

14. The Role of Epigenetics in Neurodegenerative Diseases

By Luca Lovrečić, Aleš Maver, Maja Zadel and Borut Peterlin


Open access peer-reviewed

15. Plasma Membrane Channels Formed by Connexins or Pannexins in Microglia: Possible Role in the Inflamed Brain

By Juan A. Orellana


Open access peer-reviewed

16. Influence of Obesity on Neurodegenerative Diseases

By Rana Awada , Avinash Parimisetty and Christian Lefebvre d’Hellencourt


Open access peer-reviewed

17. Electro-Physiological Approaches to Monitoring Neuro- Degenerative Diseases

By Manuel J. Rojas, Camilo Orozco and Francisco Olea


Open access peer-reviewed

18. Oxidative Changes and Possible Effects of Polymorphism of Antioxidant Enzymes in Neurodegenerative Disease

By Eva Babusikova, Andrea Evinova, Jozef Hatok, Dusan Dobrota and Jana Jurecekova


Open access peer-reviewed

19. Intermediate Filaments in Neurodegenerative Diseases

By Rodolphe Perrot and Joel Eyer


Open access peer-reviewed

20. Astrocytes Role in Parkinson: A Double-Edged Sword

By Ricardo Cabezas, Marco Fidel Avila, Daniel Torrente, Ramon Santos El-Bachá, Ludis Morales, Janneth Gonzalez and George E. Barreto


Open access peer-reviewed

21. Zinc and Neurodegenerative Diseases

By Masahiro Kawahara, Keiko Konoha, Hironari Koyama, Susumu Ohkawara and Yutaka Sadakane


Open access peer-reviewed

22. Oligodendrocyte Metabolic Stress in Neurodegeneration

By Daniel Radecki and Alexander Gow


Open access peer-reviewed

23. Spinal Muscular Atrophy: Classification, Diagnosis, Background, Molecular Mechanism and Development of Therapeutics

By Faraz Tariq Farooq, Martin Holcik and Alex MacKenzie


Open access peer-reviewed

24. Pharmacological Treatment of Acute Ischemic Stroke

By Humberto Mestre, Yael Cohen-Minian, Daniel Zajarias-Fainsod and Antonio Ibarra


Open access peer-reviewed

25. Cognitive Dysfunction Syndrome in Senior Dogs

By Camilo Orozco Sanabria, Francisco Olea and Manuel Rojas


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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