Open access peer-reviewed Edited Volume

Gene Expression and Regulation in Mammalian Cells

Transcription Toward the Establishment of Novel Therapeutics

Edited by Fumiaki Uchiumi

Tokyo University of Science

Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.

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Gene Expression and Regulation in Mammalian CellsTranscription Toward the Establishment of Novel TherapeuticsEdited by Fumiaki Uchiumi

Published: February 28th 2018

DOI: 10.5772/intechopen.74045

ISBN: 978-953-51-3868-6

Print ISBN: 978-953-51-3867-9

eBook (PDF) ISBN: 978-953-51-4099-3

Copyright year: 2018

Books open for chapter submissions

13509 Total Chapter Downloads

7 Crossref Citations

12 Web of Science Citations

15 Dimensions Citations


Open access peer-reviewed

1. Stress Response of Dietary Phytochemicals in a Hormetic Manner for Health and Longevity

By Ceren Gezer


Open access peer-reviewed

2. Control of Ribosomal RNA Transcription by Nutrients

By Yuji Tanaka and Makoto Tsuneoka


Open access peer-reviewed

3. DNA Methylation in Mammalian Cells

By Patrick Winata, Marissa William, Victoria Keena, Ken Takahashi and Yuen Yee Cheng


Open access peer-reviewed

4. Histone Chaperones Regulate Mammalian Gene Expression

By Debasree Dutta, Khaja Mohieddin Syed and Ananda Mukherjee


Open access peer-reviewed

5. Epigenetic Factors: Key Regulators Targeted in Cancers

By Nicole S L Yeo-Teh, Yoshiaki Ito and Sudhakar Jha


Open access peer-reviewed

6. Hydroxymethylation Influences on Intestinal Epithelial Cells in Health and Disease

By Kayci Huff-Hardy and John H. Kwon


Open access peer-reviewed

7. The Key Role of E2F in Tumor Suppression through Specific Regulation of Tumor Suppressor Genes in Response to Oncogenic Changes

By Kenta Kurayoshi, Eiko Ozono, Ritsuko Iwanaga, Andrew P. Bradford, Hideyuki Komori, Keigo Araki and Kiyoshi Ohtani


Open access peer-reviewed

8. Changes in the Expression and the Role of Sirtuin 3 in Cancer Cells and in Cardiovascular Health and Disease

By Ozkan Ozden and Kevser Tural


Open access peer-reviewed

9. Regulatory Functions of Pax1 and Pax9 in Mammalian Cells

By V. Sivakamasundari, Petra Kraus and Thomas Lufkin


Open access peer-reviewed

10. The Hypoxia-Inducible Factor-1α in Angiogenesis and Cancer: Insights from the Drosophila Model

By Vasilia Tamamouna and Chrysoula Pitsouli


Open access peer-reviewed

11. Manipulation and Study of Gene Expression in Neurotoxin- Treated Neuronal PC12 and SH-SY5Y Cells for In Vitro Studies of Parkinson’s Disease

By Pascaline Aimé, Xiaotian Sun and Lloyd A. Greene


Open access peer-reviewed

12. Transcriptional Regulation of the Intestinal Cancer Stem Cell Phenotype

By Antoine Gleizes, Vincent Cavaillès and Marion Lapierre


Open access peer-reviewed

13. Passenger or Driver: Can Gene Expression Profiling Tell Us Anything about LINE-1 in Cancer?

By Stephen Ohms, Jane E. Dahlstrom and Danny Rangasamy


Open access peer-reviewed

14. Viral Modulation of Host Translation and Implications for Vaccine Development

By Abhijeet Bakre and Ralph A. Tripp


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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