Open access peer-reviewed Edited Volume

DNA Replication

Current Advances

Edited by Herve Seligmann

University of Chicago, United States of America

The study of DNA advanced human knowledge in a way comparable to the major theories in physics, surpassed only by discoveries such as fire or the number zero. However, it also created conceptual shortcuts, beliefs and misunderstandings that obscure the natural phenomena, hindering its better understanding. The deep conviction that no human knowledge is perfect, but only perfectible, should function as a fair safeguard against scientific dogmatism and enable open discussion. With this aim, this book will offer to its readers 30 chapters on current trends in the field of DNA replication. As several contributions in this book show, the study of DNA will continue for a while to be a leading front of scientific activities.

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DNA ReplicationCurrent AdvancesEdited by Herve Seligmann

Published: August 1st 2011

DOI: 10.5772/791

ISBN: 978-953-307-593-8

eBook (PDF) ISBN: 978-953-51-4470-0

Copyright year: 2011

Books open for chapter submissions

97231 Total Chapter Downloads

25 Crossref Citations

92 Web of Science Citations

93 Dimensions Citations


Open access peer-reviewed

1. DNA Structure: Alphabet Soup for the Cellular Soul

By P. Shing Ho and Megan Carter


Open access peer-reviewed

2. Replication Demands an Amendment of the Double Helix

By You Cheng Xu


Open access peer-reviewed

3. Phosphorothioation: An Unusual Post-Replicative Modification on the DNA Backbone

By Lianrong Wang, Shi Chen and Zixin Deng


Open access peer-reviewed

4. Mitosis and DNA Replication and Life Origination Hydrate Hypotheses: Common Physical and Chemical Grounds

By Ostrovskii Victor E. and Kadyshevich Elena A.


Open access peer-reviewed

5. Strand-specific Composition Bias in Bacterial Genomes

By Feng-Biao Guo and Lu-Wen Ning


Open access peer-reviewed

6. Mutation Patterns Due to Converging Mitochondrial Replication and Transcription Increase Lifespan, and Cause Growth Rate-Longevity Tradeoffs

By Hervé Seligmann


Open access peer-reviewed

7. Mitochondrial DNA Replication in Health and Disease

By Nadezda Apostolova and Juan V. Esplugues


Open access peer-reviewed

8. Damage and Replication Stress Responses

By Haiying Wang, Ping Shen and Wei-Guo Zhu


Open access peer-reviewed

9. Relationship between Fork Progression and Initiation of Chromosome Replication in E. coli

By Elena C. Guzmán, Israel Salguero, Carmen Mata Martín, Elena López Acedo, Estrella Guarino, Ma Antonia Sánchez-Romero, Vic Norris and Alfonso Jiménez-Sánchez


Open access peer-reviewed

10. Replication Origin Selection and Pre-Replication Complex Assembly

By Kusic-Tisma Jelena and Stefanovic Dragana


Open access peer-reviewed

11. The Coordination between DNA Replication Initiation and Other Cell Cycle Events

By Shijiao Huang and Chuanmao Zhang


Open access peer-reviewed

12. The Organisation of Replisomes

By Anna Ligasová and Karel Koberna


Open access peer-reviewed

13. Eukaryotic Replication Barriers: How, Why and Where Forks Stall

By Jacob Z. Dalgaard, Emma L. Godfrey and Ramsay J. MacFarlane


Open access peer-reviewed

14. Control of Telomeric DNA Replication: Genetics, Molecular Biology, and Physiology

By Akira Matsuura and Aiko Matsui


Open access peer-reviewed

15. Telomere Maintenance in Organisms without Telomerase

By James M. Mason, Hemakumar M. Reddy and Radmila Capkova Frydrychova


Open access peer-reviewed

16. Eukaryote DNA Replication and Recombination: an Intimate Association

By Ramsay J. McFarlane, Khalid Al-Zeer and Jacob Z. Dalgaard


Open access peer-reviewed

17. Cell Cycle Regulation of DNA Replication in S. cerevisiae

By Jorrit M. Enserink


Open access peer-reviewed

18. Free Histones and the Cell Cycle

By Douglas Maya, Macarena Morillo-Huesca, Sebastián Chávez and Mari-Cruz Muñoz-Centeno


Open access peer-reviewed

19. Involvement of Linker Histones in the Regulation of Replication Timing

By Christophe Thiriet, Gwenola Auda-Boucher and Yvonnick Chéraud


Open access peer-reviewed

20. Replication Timing: Evolution, Nuclear Organization and Relevance for Human Disease

By Megan Lynne Wright and Frank Grützner


Open access peer-reviewed

21. The Silencing Face of DNA Replication: Gene Repression Mediated by DNA Replication Factors

By Patricia Chisamore-Robert, Daniel Jeffery and Krassimir Yankulov


Open access peer-reviewed

22. Faithful DNA Replication Requires Regulation of CDK Activity by Checkpoint Kinases

By Claus Storgaard Sørensen, Halfdan Beck, Viola Nähse-Kumpf and Randi G. Syljuåsen


Open access peer-reviewed

23. Regulation of the G1/S Transition in Adult Liver: Expression and Activation of the Cyclin Dependent Kinase Cdk1 in Differentiated Hepatocytes is Controlled by Extracellular Signals and is Crucial for Commitment to DNA Replication

By Loyer Pascal and Corlu Anne


Open access peer-reviewed

24. Binding of Human MCM-BP with MCM2-7 Proteins

By Ryoko Kon, Shunsuke Kusunoki, Naohito Nozaki and Yukio Ishimi


Open access peer-reviewed

25. DNA Replication in Animal Systems Lacking Thioredoxin Reductase I

By Edward E. Schmidt


Open access peer-reviewed

26. Prevalence of Reactivation of Hepatitis B Virus DNA Replication in Rheumatoid Arthritis Patients

By Yukitomo Urata, Ryoko Uesato and Dai Tanaka


Open access peer-reviewed

27. Oncogenic Aspects of HPV Infections of the Female Genital Tract

By Josko Zekan, Maja Sirotkovic-Skerlev and Mihael Skerlev


Open access peer-reviewed

28. The Role of E2 Proteins in Papillomavirus DNA Replication

By Reet Kurg


Open access peer-reviewed

29. Topoisomerase I and II Expression in Recurrent Colorectal Cancer Cells: A Dubious Matter

By Panagiotis Gouveris, Elias Skopelitis and Nicolas Tsavaris


Open access peer-reviewed

30. Bacterial Genetics of Large Mammalian DNA Viruses: Bacterial Artificial Chromosomes as a Prerequisite for Efficiently Studying Viral DNA Replication and Functions

By Felix Wussow, Tanja Spieckermann, Anne Brunnemann, Linda Hüske, Tuna Toptan and Helmut Fickenscher


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI
  • BIOSIS Previews

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