Open access peer-reviewed Edited Volume

Gene Expression and Regulation in Mammalian Cells

Transcription From General Aspects

Edited by Fumiaki Uchiumi

Tokyo University of Science

"Central dogma" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells.

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Gene Expression and Regulation in Mammalian CellsTranscription From General AspectsEdited by Fumiaki Uchiumi

Published: February 21st 2018

DOI: 10.5772/intechopen.70352

ISBN: 978-953-51-3856-3

Print ISBN: 978-953-51-3855-6

eBook (PDF) ISBN: 978-953-51-4095-5

Copyright year: 2018

Books open for chapter submissions

18940 Total Chapter Downloads

9 Crossref Citations

14 Web of Science Citations

18 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Current Studies in Transcriptional Control System; Toward the Establishment of Therapies against Human Diseases

By Fumiaki Uchiumi


Open access peer-reviewed

2. Regulation of Mammalian Gene Expression

By Partha P. Mitra


Open access peer-reviewed

3. Mammalian Cis-Acting RNA Sequence Elements

By Irina Vlasova-St. Louis and Calandra Sagarsky


Open access peer-reviewed

4. Influence of Endogenous Viral Sequences on Gene Expression

By Kozue Sofuku and Tomoyuki Honda


Open access peer-reviewed

5. Cross-Talk Categorisations in Data-Driven Models of Signalling Networks: A System-Level View

By A.K.M. Azad, Alfons Lawen and Jonathan M. Keith


Open access peer-reviewed

6. Interplay between Transcription and RNA Degradation

By Toshimichi Yamada, Masami Nagahama and Nobuyoshi Akimitsu


Open access peer-reviewed

7. Post-Transcriptional Control of RNA Expression in Cancer

By Carlos DeOcesano-Pereira, Fernando Janczur Velloso, Ana Claudia Oliveira Carreira, Carolina Simões Pires Ribeiro, Sheila Maria Brochado Winnischofer, Mari Cleide Sogayar and Marina Trombetta-Lima


Open access peer-reviewed

8. Current Status for Application of RNA Interference Technology as Nucleic Acid Drug

By Tomoko Takahashi, Yuko Nakano and Kumiko Ui-Tei


Open access peer-reviewed

9. Gene Expression during the Activation of Human B Cells

By Youming Zhang


Open access peer-reviewed

10. The Interplay between Transcription Factors and Epigenetic Modifications in Th2 Cells

By Atsushi Onodera, Kota Kokubo and Toshinori Nakayama


Open access peer-reviewed

11. Post-Transcriptional and Translational Mechanisms of Regulation of Gene Expression in T Cell Subsets

By Roman Istomine and Ciriaco A. Piccirillo


Open access peer-reviewed

12. Phosphorylation of PRH/HHEX by Protein Kinase CK2 Regulates Cell Proliferation and Cell Migration in Diverse Cell Types

By Padma-Sheela Jayaraman, Kerry S. Wadey, Sarah J. George and Kevin Gaston


Open access peer-reviewed

13. Dual Role of METCAM/MUC18 Expression in the Progression of Cancer Cells

By Guang-Jer Wu


Open access peer-reviewed

14. Methylation of NF-κB and its Role in Gene Regulation

By Han Wei, Lakshmi Prabhu, Antja-Voy Hartley, Matthew Martin, Emily Sun, Guanglong Jiang, Yunlong Liu and Tao Lu


Open access peer-reviewed

15. SOX Genes and Cancer

By Li Cui, Xinyuan Zhao and Shen Hu


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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