Open access peer-reviewed Edited Volume

Pluripotent Stem Cells

From the Bench to the Clinic

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

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Pluripotent Stem CellsFrom the Bench to the ClinicEdited by Minoru Tomizawa

Published: July 20th 2016

DOI: 10.5772/61549

ISBN: 978-953-51-2472-6

Print ISBN: 978-953-51-2471-9

eBook (PDF) ISBN: 978-953-51-7287-1

Copyright year: 2016

Books open for chapter submissions

32970 Total Chapter Downloads

14 Crossref Citations

22 Web of Science Citations

31 Dimensions Citations


Open access peer-reviewed

1. Introductory chapter: Pluripotent stem cells

By Minoru Tomizawa


Open access peer-reviewed

2. Embryonic Stem Cells: Keeping Track of the Pluripotent Status

By Liesbeth Vossaert, Ellen Scheerlinck and Dieter Deforce


Open access peer-reviewed

3. States of Pluripotency: Naïve and Primed Pluripotent Stem Cells

By Daman Kumari


Open access peer-reviewed

4. Pluripotent Stem Cells and Their Dynamic Niche

By Yvonne Reinwald, Jessica Bratt and Alicia El Haj


Open access peer-reviewed

5. Rejuvenation on the Road to Pluripotency

By Tapash Jay Sarkar and Vittorio Sebastiano


Open access peer-reviewed

6. Genomic Instability of Pluripotent Stem Cells: Origin and Consequences

By Elena Lo Furno, Siem van der Laan and Domenico Maiorano


Open access peer-reviewed

7. Moving toward Xeno-free Culture of Human Pluripotent Stem Cells

By Kamthorn Pruksananonda and Ruttachuk Rungsiwiwut


Open access peer-reviewed

8. Affordable Clean Air Facility for (Stem) Cell Therapy in an Academic Setting

By Una Chen


Open access peer-reviewed

9. Induced Pluripotent Stem Cells for Clinical Use

By Tomohisa Seki and Keiichi Fukuda


Open access peer-reviewed

10. Pluripotent Stem Cells in Toxicity Testing: An Omics Approach

By Smita Jagtap, Kesavan Meganathan and Vilas Wagh


Open access peer-reviewed

11. Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of Brain Diseases

By Šárka Lehtonen, Marko Lehtonen and Jari Koistinaho


Open access peer-reviewed

12. Modeling Hypertrophic Cardiomyopathy with Human Induced Pluripotent Stem Cells

By Marisa Ojala and Katriina Aalto-Setälä


Open access peer-reviewed

13. Stem Cells for Modeling Human Disease

By Martín F, Sánchez‐Gilabert A, Tristán‐Manzano M and Benabdellah K


Open access peer-reviewed

14. Modelling Neurodegenerative Diseases Using Human Pluripotent Stem Cells

By Vanessa J. Hall


Open access peer-reviewed

15. From Human Pluripotent Stem Cells to Peripheral Neurons

By Roxana Nat


Open access peer-reviewed

16. Temporal Dynamics of Spontaneous Ca2+ Transients, ERBB4, vGLUT1, GAD1, Connexin, and Pannexin Genes in Early Stages of Human Stem Cell Neurodifferentiation

By Pallavi V. Limaye, Michele L. McGovern, Mandakini B. Singh, Katerina D. Oikonomou, Glenn S. Belinsky, Erika Pedrosa, Herbert M. Lachman and Srdjan D. Antic


Open access peer-reviewed

17. Pluripotent Stem Cells: Differentiation Potential and Therapeutic Efficacy for Cartilage Repair

By Wei Seong Toh


Open access peer-reviewed

18. Cartilage Regeneration Using Pluripotent Stem Cell‐Derived Chondroprogenitors: Promise and Challenges

By Naoki Nakayama, John Y. Lee, Nadine Matthias, Katsutsugu Umeda, Qing Yan and Johnny Huard


Open access peer-reviewed

19. Retinoic Acid Receptor Signaling in the Differentiation of Pluripotent Stem Cells into Skeletal Muscle Lineage

By Jihong Chen and Qiao Li


Open access peer-reviewed

20. Generating Self-Organizing Stomach Tissue from Mouse Embryonic Stem Cells

By Taka-aki K. Noguchi


Open access peer-reviewed

21. Human Embryonic Stem Cells and Induced Pluripotent Stem Cells: The Promising Tools for Insulin-Producing Cell Generation

By Wilairat Leeanansaksiri, Piyaporn Rattananinsruang and Chavaboon Dechsukhum


Open access peer-reviewed

22. Stem Cell-Derived Regulatory T Cells for Therapeutic Use

By Mohammad Haque, Praneet Sandhu and Jianxun Song


Open access peer-reviewed

23. Mesenchymal Stem Cells: Biological Characteristics and Potential Clinical Applications for Haematopoietic Stem Cell Transplantation

By Teresa de Souza Fernandez and Cecília de Souza Fernandez


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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