Open access peer-reviewed Edited Volume

Stem Cells in Clinic and Research

Edited by Ali Gholamrezanezhad

Johns Hopkins University, United States of America

Based on our current understanding of cell biology and strong supporting evidence from previous experiences, different types of human stem cell populations are capable of undergoing differentiation or trans-differentiation into functionally and biologically active cells for use in therapeutic purposes. So far, progress regarding the use of both in vitro and in vivo regenerative medicine models already offers hope for the application of different types of stem cells as a powerful new therapeutic option to treat different diseases that were previously considered to be untreatable. Remarkable achievements in cell biology resulting in the isolation and characterization of various stem cells and progenitor cells has increased the expectation for the development of a new approach to the treatment of genetic and developmental human diseases. Due to the fact that currently stem cells and umbilical cord banks are so strictly defined and available, it seems that this mission is investigationally more practical than in the past. On the other hand, studies performed on stem cells, targeting their conversion into functionally mature tissue, are not necessarily seeking to result in the clinical application of the differentiated cells; In fact, still one of the important goals of these studies is to get acquainted with the natural process of development of mature cells from their immature progenitors during the embryonic period onwards, which can produce valuable results as knowledge of the developmental processes during embryogenesis. For example, the cellular and molecular mechanisms leading to mature and adult cells developmental abnormalities are relatively unknown. This lack of understanding stems from the lack of a good model system to study cell development and differentiation. Hence, the knowledge reached through these studies can prove to be a breakthrough in preventing developmental disorders. Meanwhile, many researchers conduct these studies to understand the molecular and cellular basis of cancer development. The fact that cancer is one of the leading causes of death throughout the world, highlights the importance of these researches in the fields of biology and medicine.

Read more >Order hardcopy
Stem Cells in Clinic and ResearchEdited by Ali Gholamrezanezhad

Published: August 23rd 2011

DOI: 10.5772/740

ISBN: 978-953-307-797-0

eBook (PDF) ISBN: 978-953-51-6455-5

Copyright year: 2011

Books open for chapter submissions

123493 Total Chapter Downloads

37 Crossref Citations

75 Web of Science Citations

86 Dimensions Citations


Open access peer-reviewed

1. Stem Cells: General Features and Characteristics

By Hongxiang Hui, Yongming Tang, Min Hu and Xiaoning Zhao


Open access peer-reviewed

2. Human Cord Blood-Derived Stem Cells in Transplantation and Regenerative Medicine

By Cornel Iancu, Ioana Ilie, Lucian Mocan, Carmen Georgescu, Razvan Ilie, Ileana Duncea, Teodora Mocan, Dana Iancu, and Florin Zaharie


Open access peer-reviewed

3. Mesenchymal Stem Cells: Immunology and Therapeutic Benefits

By Najib El Haddad


Open access peer-reviewed

4. How do Mesenchymal Stem Cells Repair?

By Patricia Semedo, Marina Burgos-Silva, Cassiano Donizetti-Oliveira and Niels Olsen Saraiva Camara


Open access peer-reviewed

5. Immunogenicity and Immune-Modulating Properties of Human Stem Cells

By Jan Nehlin, Adiba Isa and Torben Barington


Open access peer-reviewed

6. Stem Cell Culture Collection - Promising Strategy for Animal Genetic Resource Preservation

By Weijun Guan, Xiangchen Li, Dapeng Jin, Xiaohong He, Yabin Pu, Qianjun Zhao, Taofeng Lu, Chunyu Bai, Shen Wu, Xiaohua Su and Yuehui Ma


Open access peer-reviewed

7. The Role of SOX2 in Maintaining Pluripotency and Differentiation of Human Embryonic Stem Cells

By Keiko Adachi, Hirofumi Suemori, Norio Nakatsuji and Eihachiro Kawase


Open access peer-reviewed

8. The Role of MicroRNAs in Regulating Cancer Stem Cells

By Musaffe Tuna and Christopher I. Amos


Open access peer-reviewed

9. Are We There Yet? A Story About Cardiac Stem Cells

By Shizuka Uchida, Piera De Gaspari and Thomas Braun


Open access peer-reviewed

10. Stem Cell Therapy in Myocardial Infarction Clinical Point of View and the Results of the REANIMA Study (REgenerAtion of Myocardium with boNe Marrow Mononuclear Cells in MyocArdial Infarction)

By Slobodan Obradovic, Bela Balint and Zoran Trifunovic


Open access peer-reviewed

11. Randomized Clinical Trials in Stem Cell Therapy for the Heart - Old and New Types of Cells for Cardiovascular Repair

By Ricardo Sanz-Ruiz, Adolfo Villa Arranz, Enrique Gutiérrez Ibañes, María Eugenia Fernández Santos, Pedro Luis Sánchez Fernández and Francisco Fernández-Avilés


Open access peer-reviewed

12. Autologous Stem Cells for Cardiac Repair: New Insights on Clinical Trial Safety and Best Cell Source

By Nicolas Noiseux, Louis Mathieu Stevens, Jessica Forcillo and Samer Mansour


Open access peer-reviewed

13. Stem Cell Transplantation for the Treatment of Peripheral Arterial Disease

By Nikolaos Papanas


Open access peer-reviewed

14. Myogenic Potential of Murine Embryonic Stem Cells in the Dmdmdx Mouse Model for Duchenne Muscular Dystrophy

By Danielle Ayub-Guerrieri, Poliana C. M. Martins-Machado, Paula C.G. Onofre-Oliveira, Lygia V. Pereira, Camila F. Almeida, Vanessa F. Lopes and Mariz Vainzof


Open access peer-reviewed

15. Stem Cell in Neurological Disorders

By Nirmeen Kishk and Noha Abokrysha


Open access peer-reviewed

16. Cell Therapy for Parkinson’s Disease: Failure or Success?

By Magdalena Guerra-Crespo, Alberto K. De la Herrán-Arita, Arturo Hernández-Cruz, José Bargas and René Drucker-Colín


Open access peer-reviewed

17. Stem Cell Therapy for Neuromuscular Diseases

By Mirella Meregalli, Andrea Farini and Yvan Torrente


Open access peer-reviewed

18. Treatment of the end Stage Liver Cirrhosis by Human Umbilical Cord Blood Stem Cells: Preliminary Results

By Jong Yoon Bahk, Zhengfu Piao, Jae Hun Jung and Hoon Han


Open access peer-reviewed

19. Stem Cell Therapy for Patients with Chronic Liver Disease

By Reebye, V; Levičar, N and Habib, N.


Open access peer-reviewed

20. Pancreatic Stem Cells: Unresolved Business

By Fang-Xu Jiang and Grant Morahan


Open access peer-reviewed

21. Cell Sources for Treating Diabetes

By Subhshri Sahu, Mugdha V. Joglekar, Sundy N. Y. Yang and Anandwardhan A. Hardikar


Open access peer-reviewed

22. Stem Cell Therapy for Islet Regeneration

By Phuc Pham Van


Open access peer-reviewed

23. Topical Stem and Progenitor Cell Therapy for Diabetic Foot Ulcers

By Aonghus O’Loughlin and Timothy O’Brien


Open access peer-reviewed

24. Regeneration of the Kidney - Viewed from ES Cell

By Hirotsugu Iwatani and Enyu Imai


Open access peer-reviewed

25. Periodontal Ligament Stem Cells

By Hidefumi Maeda, Naohisa Wada, Shinsuke Fujii, Atsushi Tomokiyo and Akifumi Akamine


Open access peer-reviewed

26. Clinical Stem Cell Imaging and In vivo Tracking

By Sahar Mirpour and Ali Gholamrezanezhad


Open access peer-reviewed

27. Invasive Fungal Infections in Patients with Acute Leukemia and Hematopoietic Stem Cell Transplant Recipients

By Maxim Norkin and John R. Wingard


Open access peer-reviewed

28. Synchrotron Radiation and Nanotechnology for Stem Cell Research

By Alessandra Giuliani, Fabrizio Fiori, Adrian Manescu, Vladimir S. Komlev, Chiara Renghini and Franco Rustichelli


Open access peer-reviewed

29. Spontaneous Generation of Neurospheres from Mouse Embryonic Stem Cells

By Roberto Di Maio, Kommu Naga Mohan, Brianna Heath and Leonardo D’Aiuto


Open access peer-reviewed

30. Multidrug Resistance Transporters – Roles in maintaining Cancer Stem-Like Cells

By To, Kenneth K.W. and Fu, L.W.


Open access peer-reviewed

31. Associated Adeno Virus Vector for Producing Induced Pluripotent Stem Cells (IPS) for Human Somatic Cells

By Edilamar Menezes Oliveira and M Ian Phillips


Open access peer-reviewed

32. Raman Spectroscopy for Noninvasive Monitoring of Umbilical Cord Mesenchymal Stem Cells Viability Transitions

By P.Chen, F.Zhang, L.Lin, H.Bai, L.Zhang, G.Q.Tang, H.Fang, G.G.Mu, W. Gong, Z. P. Liu, Z. B. Han, H. Zhao and Z. C. Han


Open access peer-reviewed

33. Novel Platforms to Create Labeled Stem Cells

By Andrew Fontes, Rene Quintanilla and Uma Lakshmipathy


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£169

Order now

Residents of European Union countries need to add a Book Value-Added Tax Rate based on their country of residence. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase