Open access peer-reviewed Edited Volume

Pluripotent Stem Cells


Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.

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Pluripotent Stem CellsEdited by Deepa Bhartiya

Published: August 28th 2013

DOI: 10.5772/45917

ISBN: 978-953-51-1192-4

eBook (PDF) ISBN: 978-953-51-7178-2

Copyright year: 2013

Books open for chapter submissions

73907 Total Chapter Downloads

27 Crossref Citations

32 Web of Science Citations

52 Dimensions Citations


Open access peer-reviewed

1. An Overview of Pluripotent Stem Cells

By Deepa Bhartiya, Punam Nagvenkar, Kalpana Sriraman and Ambreen Shaikh


Open access peer-reviewed

2. Pluripotent Adult Stem Cells: A Potential Revolution in Regenerative Medicine and Tissue Engineering

By Tsz Kin Ng, Daniel Pelaez, Veronica R. Fortino, Jordan Greenberg and Herman S. Cheung


Open access peer-reviewed

3. De-Differentiation of Somatic Cells to a Pluripotent State

By Cristiane V. Wenceslau, Irina Kerkis, Nelson F. Lizier and Alexandre Kerkis


Open access peer-reviewed

4. The Dark Side of Pluripotency – Cancer Stem Cell

By Patricia Ng and Wang Cheng-I


Open access peer-reviewed

5. Conditions and Techniques for Mouse Embryonic Stem Cell Derivation and Culture

By Kun-Hsiung Lee


Open access peer-reviewed

6. Human Testis–Derived Pluripotent Cells and Induced Pluripotent Stem Cells

By Hideyuki Kobayashi, Koichi Nagao and Koichi Nakajima


Open access peer-reviewed

7. Generation of Induced Pluripotent Stem Cells from Dental Pulp Somatic Cells

By Nelson F. Lizier, Irina Kerkis and Cristiane V. Wenceslau


Open access peer-reviewed

8. Molecular Mechanisms Underlying Pluripotency

By Erhard Bieberich and Guanghu Wang


Open access peer-reviewed

9. Stem Cells and Epigenetic Reprogramming

By Perla Cota, Mehdi Shafa and Derrick E. Rancourt


Open access peer-reviewed

10. Epigenetic Reprogramming in Stem Cells

By Richard L. Eckert, Yasin Kizilyer and Candace L. Kerr


Open access peer-reviewed

11. Multiple Paths to Reprogramming

By Antonio Lo Nigro and Catherine M. Verfaillie


Open access peer-reviewed

12. Induced Pluripotent Stem Cells: Current and Emerging Technologies

By Jacob Kimmel and Kiminobu Sugaya


Open access peer-reviewed

13. Molecular Mechanisms of Embryonic Stem Cell Pluripotency

By Guofeng Han, Hongtao Wang and Jijun Hao


Open access peer-reviewed

14. Epigenetic Instability in Embryonic Stem Cells

By Takuro Horii and Izuho Hatada


Open access peer-reviewed

15. Function of KLF4 in Stem Cell Biology

By Ying Shi and Walden Ai


Open access peer-reviewed

16. β1,4-Galactosyltransferases, Potential Modifiers of Stem Cell Pluripotency and Differentiation

By Michael Wassler


Open access peer-reviewed

17. Advances in Stem Cell Therapies

By Thomas Lufkin and Joel Sng


Open access peer-reviewed

18. Embryonic Stem Cell Therapy – From Bench to Bed

By Laura E. Sperling


Open access peer-reviewed

19. Disease Models for the Genetic Cardiac Diseases

By Mari Pekkanen-Mattila, Kristiina Rajala and Katriina Aalto-Setälä


Open access peer-reviewed

20. Pluripotent Stem Cells to Model Human Cardiac Diseases

By Calvin C. Sheng and Charles C. Hong


Open access peer-reviewed

21. Pluripotent Stem Cells for Cardiac Cell Therapy: The Application of Cell Sheet Technology

By Hidetoshi Masumoto and Jun K. Yamashita


Open access peer-reviewed

22. Human Pluripotent Stem Cells Modeling Neurodegenerative Diseases

By Roxana Nat, Andreas Eigentler and Georg Dechant


Open access peer-reviewed

23. Induced Pluripotent Stem Cells as a Source of Hepatocytes

By Minoru Tomizawa, Fuminobu Shinozaki, Takao Sugiyama, Shigenori Yamamoto, Makoto Sueishi and Takanobu Yoshida


Open access peer-reviewed

24. Induced Pluripotent Stem Cells: Therapeutic Applications in Monogenic and Metabolic Diseases, and Regulatory and Bioethical Considerations

By Antonio Liras, Cristina Segovia and Aline S. Gabán


Open access peer-reviewed

25. Safety Assessment of Reprogrammed Cells Prior to Clinical Applications: Potential Approaches to Eliminate Teratoma Formation

By Juan Carlos Polanco and Andrew L. Laslett


Open access peer-reviewed

26. Stem Cells in Tissue Engineering

By Shohreh Mashayekhan, Maryam Hajiabbas and Ali Fallah


Open access peer-reviewed

27. Ethical Considerations on Stem Cell Research

By Andreas M. Weiss, Michael Breitenbach, Mark Rinnerthaler and Günter Virt


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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