Open access peer-reviewed Edited Volume

Autophagy - A Double-Edged Sword

Cell Survival or Death?

Edited by Yannick Bailly

University of Strasbourg

The chapters in this book review the latest advances in the molecular mechanisms of autophagy, highlighting some of the most challenging research topics. The focus is mainly on how this basic cell defense mechanism comes into play in various pathologies, including liver diseases, myopathies, infectious diseases, cancers and neurodegenerative diseases. In these diseases, the contradictory autophagy roles of cell survival versus cell death emphasize the necessity of taking into account this double-edged nature in future development of already promising, autophagy- modulating, therapies.

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Autophagy - A Double-Edged SwordCell Survival or Death?Edited by Yannick Bailly

Published: April 17th 2013

DOI: 10.5772/50855

ISBN: 978-953-51-1062-0

eBook (PDF) ISBN: 978-953-51-5366-5

Copyright year: 2013

Books open for chapter submissions

57548 Total Chapter Downloads

30 Crossref Citations

58 Web of Science Citations

87 Dimensions Citations


Open access peer-reviewed

1. Role of Human WIPIs in Macroautophagy

By Tassula Proikas-Cezanne and Daniela Bakula


Open access peer-reviewed

2. Atg8 Family Proteins — Autophagy and Beyond

By Oliver H. Weiergräber, Jeannine Mohrlüder and Dieter Willbold


Open access peer-reviewed

3. Rab GTPases in Autophagy

By Yuko Hirota, Keiko Fujimoto and Yoshitaka Tanaka


Open access peer-reviewed

4. Flow Cytometric Measurement of Cell Organelle Autophagy

By N. Panchal, S. Chikte, B.R. Wilbourn, U.C. Meier and G. Warnes


Open access peer-reviewed

5. Autophagy, the “Master” Regulator of Cellular Quality Control: What Happens when Autophagy Fails?

By A. Raquel Esteves, Catarina R. Oliveira and Sandra Morais Cardoso


Open access peer-reviewed

6. Altering Autophagy: Mouse Models of Human Disease

By Amber Hale, Dan Ledbetter, Thomas Gawriluk and Edmund B. Rucker III


Open access peer-reviewed

7. Autophagy in GNE Myopathy

By Anna Cho and Satoru Noguchi


Open access peer-reviewed

8. Autophagy and the Liver

By Ricky H. Bhogal and Simon C. Afford


Open access peer-reviewed

9. Role of Autophagy in Cancer and Tumor Progression

By Bassam Janji, Elodie Viry, Joanna Baginska, Kris Van Moer and Guy Berchem


Open access peer-reviewed

10. Role of Autophagy in Cancer

By Michiko Shintani and Kayo Osawa


Open access peer-reviewed

11. Regulation of Autophagy by Short Chain Fatty Acids in Colon Cancer Cells

By Djamilatou Adom and Daotai Nie


Open access peer-reviewed

12. Natural Compounds and Their Role in Autophagic Cell Signaling Pathways

By Azhar Rasul and Tonghui Ma


Open access peer-reviewed

13. Infectious Agents and Autophagy: Sometimes You Win, Sometimes You Lose

By Patricia Silvia Romano


Open access peer-reviewed

14. Autophagic Balance Between Mammals and Protozoa: A Molecular, Biochemical and Morphological Review of Apicomplexa and Trypanosomatidae Infections

By Thabata Lopes Alberto Duque, Xênia Macedo Souto, Valter Viana de Andrade-Neto, Vítor Ennes-Vidal and Rubem Figueiredo Sadok Menna-Barreto


Open access peer-reviewed

15. Induction of Autophagy by Anthrax Lethal Toxin

By Aiguo Wu, Yian Kim Tan and Hao A. Vu


Open access peer-reviewed

16. Up-Regulation of Autophagy Defense Mechanisms in Mouse Mesenchymal Stromal Cells in Response to Ionizing Irradiation Followed by Bacterial Challenge

By Nikolai V. Gorbunov, Thomas B. Elliott, Dennis P. McDaniel, K. Lund, Pei-Jyun Liao, Min Zhai and Juliann G. Kiang


Open access peer-reviewed

17. Role of Autophagy in Parkinson’s Disease

By Grace G.Y. Lim, Chengwu Zhang and Kah-Leong Lim


Open access peer-reviewed

18. Neuronal Autophagy and Prion Proteins

By Audrey Ragagnin, Aurélie Guillemain, Nancy J. Grant and Yannick J. R. Bailly


Open access peer-reviewed

19. Role of Autophagy in the Ovary Cell Death in Mammals

By M.L. Escobar, O.M. Echeverría and G.H. Vázquez-Nin


Open access peer-reviewed

20. Autophagy in Development and Remodelling of Mammary Gland

By Malgorzata Gajewska, Katarzyna Zielniok and Tomasz Motyl


Open access peer-reviewed

21. Integrin and Adhesion Regulation of Autophagy and Mitophagy

By Eric A. Nollet and Cindy K. Miranti


Open access peer-reviewed

22. Time Flies: Autophagy During Ageing in Drosophila

By Sebastian Wolfgang Schultz, Andreas Brech and Ioannis P. Nezis


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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