Open access peer-reviewed Edited Volume

Multiple Sclerosis - Genetics, Disease Mechanisms and Clinical Developments

Uday Kishore

Brunel University London

Prof. Kishore is the Founder-Director of the Centre for Infection, Immunity and Disease Mechanisms at Brunel University London, UK. He has spent several years at the Salk Institute for Biological Studies, La Jolla, California, and the University of Oxford for the major part of his post-doctoral training. He has authored over 250 research papers, book chapters, patents, and books (H-index 45). He is a researcher with a special interest in innate immunity, researching in the field of autoimmune diseases.


Abhishek Shastri

Central and North West London NHS Foundation Trust

A clinician-scientist in the field of immunology, neuropsychiatric, and dementias, currently working as a Consultant Psychiatrist for the London Borough of Brent Memory Services, UK. Dr. Shastri has worked on national projects involving older adults with depression and psychosis, creating an interactive dashboard for NHS Trusts across England and Wales, and on clinical trials with Imperial College London.


Major Histocompatibility Complex Single Nucleotide Polymorphisms Genetic Susceptibility Pathogenic Peptide Antigen Presentation Autoantibodies Macrophages T Cells CNS Lesions Cognitive Dysfunction Neuroimaging Clinical Trials

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About the book

Multiple sclerosis (MS) is a neurological condition that affects the Central Nervous System. For a person being diagnosed with MS, it can mean a lifelong illness that ranges from being mild to severely debilitating. There is no known cure for the disease. Over the years, extensive research has been carried out to better understand its etiology and pathogenesis, alongside robust clinical trials being conducted to develop effective therapeutic avenues. Research studies and clinical trials continue to take place across the world to help find a cure for MS. There is a very close interplay of immunological mechanisms in the development and progression of MS.

This book aims to bring together the latest, cutting-edge research findings along with expert commentary on epidemiology, etiology, pathogenesis, immunology, clinical treatment modalities, neuroimaging, and neuropsychiatric manifestations of this chronic inflammatory disease affecting the brain and spinal cord. The book also aims to provide an in-depth exploration of current and future directions for understanding immunology, neuroscience, and the development of potent treatment modalities.

Publishing process

Book initiated and editor appointed

Date completed: November 23rd 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: December 21st 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: February 19th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: May 10th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: July 9th 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Uday Kishore

Brunel University London

Prof. Uday Kishore is a teacher and a scientist with a special interest in innate immunity. He was the Founder-Director of the Centre for Infection, Immunity and Disease Mechanisms, Brunel University London. He gained his BSc degree from S.P. Jain College, Sasaram, Bihar, India; his MSc degree from Hindu College, Delhi University; and PhD from the Department of Zoology, University of Delhi and CSIR Institute of Genomics and Integrative Biology, Delhi, India. After spending a year at the Salk Institute for Biological Studies, La Jolla, California, he moved to the University of Oxford for the major part of his post-doctoral training, first at the MRC Immunochemistry Unit, Department of Biochemistry, and then at the Weatherall Institute of Molecular Medicine, John Radcliffe Hospital. He is the recipient of the fellowships of NASA (USA), Wellcome Trust (UK) and Alexander Humboldt Foundation (Germany), MRC Investigator Prize, European Commission Young Scientist Prize, and Mother Teresa Excellence Award. Prof. Uday Kishore holds several adjunct, visiting and honorary professorial positions, nationally and internationally. He has altogether authored over 250 research papers, book chapters, patents, and books. His research focuses on how innate immunity plays a crucial role in human health and disease. He has extensive experience researching in the field of autoimmune diseases such as Systemic Lupus Erythematosus and Myasthenia gravis.

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