Open access peer-reviewed Edited Volume

Drug Discovery and Development

Present and Future

Edited by Izet Kapetanović

National Institutes of Health, United States of America

Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.

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Drug Discovery and DevelopmentPresent and FutureEdited by Izet Kapetanović

Published: December 16th 2011

DOI: 10.5772/1179

ISBN: 978-953-307-615-7

eBook (PDF) ISBN: 978-953-51-4388-8

Copyright year: 2011

Books open for chapter submissions

94442 Total Chapter Downloads

47 Crossref Citations

88 Web of Science Citations

115 Dimensions Citations


Open access peer-reviewed

1. Overview of Current Drug Discovery and Development with an Eye towards the Future

By Izet M. Kapetanovic


Open access peer-reviewed

2. Drug Discovery and Ayurveda: Win-Win Relationship Between Contemporary and Ancient Sciences

By Bhushan Patwardhan and Kapil Khambholja


Open access peer-reviewed

3. Evolutionary Biology and Drug Development

By Pierre M. Durand and Theresa L. Coetzer


Open access peer-reviewed

4. Novel Oncology Drug Development Strategies in the Era of Personalised Medicine

By C.R. Lemech, R.S. Kristeleit and H.T. Arkenau


Open access peer-reviewed

5. Drug Discovery into the 21st Century

By Klaus Pors


Open access peer-reviewed

6. Genetically Engineered Mouse Models in Preclinical Anti-Cancer Drug Development

By Sergio Y. Alcoser and Melinda G. Hollingshead


Open access peer-reviewed

7. Genetic Pharmacotherapy

By Celia Gellman, Susana Mingote, Yvonne Wang, Inna Gaisler-Salomon and Stephen Rayport


Open access peer-reviewed

8. Critical Human Hepatocyte-Based In Vitro Assays for the Evaluation of Adverse Drug Effects

By Albert P. Li


Open access peer-reviewed

9. The Use of In Vitro 3D Cell Models in Drug Development for Respiratory Diseases

By Song Huang, Ludovic Wiszniewski and Samuel Constant


Open access peer-reviewed

10. Chemical Biology: What is Its Role in Drug Discovery?

By Lisa Pirrie and Nicholas J. Westwood


Open access peer-reviewed

11. Towards Understanding Drugs on the Molecular Level to Design Drugs of Desired Profiles

By Jolanta Natalia Latosińska and Magdalena Latosińska


Open access peer-reviewed

12. De-Risking Drug Discovery Programmes Early with ADMET

By Katya Tsaioun and Steven A. Kates


Open access peer-reviewed

13. Novel Approach to High Throughput Screening for Activators of Transcription Factors

By Natalya Smirnova, Dmitry Hushpulian, Rajiv Ratan and Irina Gazaryan


Open access peer-reviewed

14. Assessment of Cell Cycle Inhibitors by Flow Cytometry

By Paolo Cappella and Jürgen Moll


Open access peer-reviewed

15. Image-Based High-Content Screening in Drug Discovery

By Marjo Götte and Daniela Gabriel


Open access peer-reviewed

16. Recent Advances in Biotherapeutics Drug Discovery and Development

By Xiaotian Zhong, Peter Neumann, Michael Corbo and Evan Loh


Open access peer-reviewed

17. Drug Discovery by Aptamers in Protozoan Infectious Diseases

By Carsten Wrenger and Henning Ulrich


Open access peer-reviewed

18. Streamlining ICH Q6B Analytical Testing of Biotherapeutics

By Elizabeth Higgins, Elisabeth Kast and Amy Lachapelle


Open access peer-reviewed

19. Biomarkers in Drug Development: A Useful Tool but Discrepant Results May Have a Major Impact

By Abdel-Baset Halim


Open access peer-reviewed

20. Nanotechnology Based Targeted Drug Delivery: Current Status and Future Prospects for Drug Development

By Sadhna Sharma and Amandeep Singh


Open access peer-reviewed

21. Silver Nanoparticles – Universal Multifunctional Nanoparticles for Bio Sensing, Imaging for Diagnostics and Targeted Drug Delivery for Therapeutic Applications

By Anitha Sironmani and Kiruba Daniel


Open access peer-reviewed

22. Mesenchymal Stem Cells as Vehicles for Targeted Therapies

By Gabriele Putz Todd, Michelle A LeRoux and Alla Danilkovitch-Miagkova


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI
  • BIOSIS Previews

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