Open access peer-reviewed Edited Volume

Challenges in Parkinson's Disease


Wojciech Kozubski

Poznań University of Medical Sciences

Parkinson's disease is a common neurological disease and affects 2% population of more than 65 years of age and 5% more than 85 years of age. Pathomechanism of this disease is still not fully understood. This book is a sum up of knowledge on the genetic factors and neuronal death mechanisms induced by excitotoxic and inflammatory agents. The authors summarize the pathophysiology observed both in patients with Parkinson's disease and in experimental models. The book also contains the latest views on drug therapy used in the treatment of parkinsonism and other therapeutic approaches for Parkinson's disease. The book ''Challenges in Parkinson's Disease'' was made as a compendium on contemporary challenges in Parkinson's disease.

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Challenges in Parkinson's DiseaseEdited by Jolanta Dorszewska

Published: August 24th 2016

DOI: 10.5772/61880

ISBN: 978-953-51-2464-1

Print ISBN: 978-953-51-2463-4

eBook (PDF) ISBN: 978-953-51-7291-8

Copyright year: 2016

Books open for chapter submissions

33254 Total Chapter Downloads

16 Crossref Citations

17 Web of Science Citations

29 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter - Genetic and Biochemical Factors in Parkinson’s Disease

By Jolanta Dorszewska and Wojciech Kozubski


Open access peer-reviewed

2. Genetics of Parkinson’s Disease: The Role of Copy Number Variations

By Valentina La Cognata, Velia D’Agata, Francesca Cavalcanti and Sebastiano Cavallaro


Open access peer-reviewed

3. Mechanisms for Neuronal Cell Death in Parkinson’s Disease: Pathological Cross Talks Between Epigenetics and Various Signalling Pathways

By S Meenalochani, ST Dheen and SSW Tay


Open access peer-reviewed

4. Inflammation: Role in Parkinson's Disease and Target for Therapy

By Patrick Flood, Naik Arbabzada and Monika Sharma


Open access peer-reviewed

5. Chronic Inflammation Connects the Development of Parkinson’s Disease and Cancer

By Zhiming Li and Chi-Meng Tzeng


Open access peer-reviewed

6. Is Chronic Systemic Inflammation a Determinant Factor in Developing Parkinson’s Disease?

By Perla Ugalde-Muñiz, Jesús Pérez-H and Anahí Chavarría


Open access peer-reviewed

7. Disorders of Sleep and Motor Control During the Impaired Cholinergic Innervation in Rat – Relevance to Parkinson’s Disease

By Jasna Saponjic, Jelena Petrovic, Jelena Ciric and Katarina Lazic


Open access peer-reviewed

8. Cognitive Impairment in Parkinson’s Disease: Historical Review, Past, and Present

By Ivan Galtier, Antonieta Nieto and Jose Barroso


Open access peer-reviewed

9. Brain Network Metabolic Changes in Patients with Parkinsonian Tremors

By Hideo Mure, David Eidelberg and Satoshi Goto


Open access peer-reviewed

10. Animal Models of Parkinson’s Disease

By Javier Blesa, Ines Trigo‐Damas, Ana Quiroga‐Varela and Natalia Lopez‐Gonzalez del Rey


Open access peer-reviewed

11. Understanding Pathophysiology of Sporadic Parkinson's Disease in Drosophila Model: Potential Opportunities and Notable Limitations

By Priyanka Modi, Ayajuddin Mohamad, Limamanen Phom, Zevelou Koza, Abhik Das, Rahul Chaurasia, Saikat Samadder, Bovito Achumi, Muralidhara, Rajesh Singh Pukhrambam and Sarat Chandra Yenisetti


Open access peer-reviewed

12. Pharmacotherapeutic Challenges in Parkinson’s Disease Inpatients

By Unax Lertxundi, Rafael Hernández, Saioa Domingo-Echaburu, Javier Peral-Aguirregoitia and Juan Medrano


Open access peer-reviewed

13. Clinical and Experimental Cell Therapy in Parkinson’s Disease

By Keun-A Chang and Seonghan Kim


Open access peer-reviewed

14. Cell-Based Therapies for Parkinson’s Disease: Preclinical and Clinical Perspectives

By Andrea R. Di Sebastiano, Michael D. Staudt, Simon M. Benoit, Hu Xu, Matthew O. Hebb and Susanne Schmid


Open access peer-reviewed

15. Stem Cell Therapy for Parkinson's Disease

By Fabin Han


Open access peer-reviewed

16. Surgical Therapy of Parkinson's Disease

By Massimo Piacentino, Giacomo Beggio and Lorenzo Volpin


Open access peer-reviewed

17. Neuro-Ophthalmologic Evaluation as a Biomarker for Diagnosis and Progression in Parkinson Disease

By María Satue, Vicente Polo, Sofía Otin, Jose M. Larrosa, Javier Obis and Elena Garcia-Martin


Open access peer-reviewed

18. Possible Treatments of Atypical Parkinsonism

By Moretti Davide Vito


Open access peer-reviewed

19. The Role of Nurses in Parkinson's Disease

By Michelle Hyczy de Siqueira Tosin and Beatriz Guitton Renaud Baptista de Oliveira


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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