Open access peer-reviewed Edited Volume

Integrative Proteomics

Edited by Hon-Chiu Leung

Baylor College of Medicine, United States of America


Tsz Kwong Man

Baylor College of Medicine, United States of America

Ricardo Flores

Baylor College of Medicine, United States of America

Proteomics was thought to be a natural extension after the field of genomics has deposited significant amount of data. However, simply taking a straight verbatim approach to catalog all proteins in all tissues of different organisms is not viable. Researchers may need to focus on the perspectives of proteomics that are essential to the functional outcome of the cells. In Integrative Proteomics, expert researchers contribute both historical perspectives, new developments in sample preparation, gel-based and non-gel-based protein separation and identification using mass spectrometry. Substantial chapters are describing studies of the sub-proteomes such as phosphoproteome or glycoproteomes which are directly related to functional outcomes of the cells. Structural proteomics related to pharmaceutics development is also a perspective of the essence. Bioinformatics tools that can mine proteomics data and lead to pathway analyses become an integral part of proteomics. Integrative proteomics covers both look-backs and look-outs of proteomics. It is an ideal reference for students, new researchers, and experienced scientists who want to get an overview or insights into new development of the proteomics field.

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Integrative ProteomicsEdited by Hon-Chiu Leung

Published: February 24th 2012

DOI: 10.5772/2473

ISBN: 978-953-51-0070-6

eBook (PDF) ISBN: 978-953-51-4343-7

Copyright year: 2012

Books open for chapter submissions

114092 Total Chapter Downloads

23 Crossref Citations

101 Web of Science Citations

105 Dimensions Citations


Open access peer-reviewed

1. Strategies for Protein Separation

By Fernanda Salvato, Mayra Costa da Cruz Gallo de Carvalho and Aline de Lima Leite


Open access peer-reviewed

2. Evolution of Proteomic Methods for Analysis of Complex Biological Samples – Implications for Personalized Medicine

By Amanda Nouwens and Stephen Mahler


Open access peer-reviewed

3. Proteomic Analyses of Cells Isolated by Laser Microdissection

By Valentina Fiorilli, Vincent P. Klink and Raffaella Balestrini


Open access peer-reviewed

4. A Critical Review of Trypsin Digestion for LC-MS Based Proteomics

By Hanne Kolsrud Hustoft, Helle Malerod, Steven Ray Wilson, Leon Reubsaet, Elsa Lundanes and Tyge Greibrokk


Open access peer-reviewed

5. Simple and Rapid Proteomic Analysis by Protease-Immobilized Microreactors

By Hiroshi Yamaguchi, Masaya Miyazaki and Hideaki Maeda


Open access peer-reviewed

6. Labeling Methods in Mass Spectrometry Based Quantitative Proteomics

By Karen A. Sap and Jeroen A. A. Demmers


Open access peer-reviewed

7. Preparation of Protein Samples for 2-DE from Different Cotton Tissues

By Chengjian Xie, Xiaowen Wang, Anping Sui and Xingyong Yang


Open access peer-reviewed

8. 2D-PAGE Database for Studies on Energetic Metabolism of the Denitrifying Bacterium Paracoccus denitrificans

By Pavel Bouchal, Robert Stein, Zbyněk Zdráhal, Peter R. Jungblut and Igor Kučera


Open access peer-reviewed

9. Targeted High-Throughput Glycoproteomics for Glyco-Biomarker Discovery

By Eunju Choi and Michelle M. Hill


Open access peer-reviewed

10. Recent Advances in Glycosylation Modifications in the Context of Therapeutic Glycoproteins

By Xiaotian Zhong and Will Somers


Open access peer-reviewed

11. Detection of Protein Phosphorylation by Open-Sandwich Immunoassay

By Yuki Ohmuro-Matsuyama, Masaki Inagaki and Hiroshi Ueda


Open access peer-reviewed

12. Phosphoproteomics: Detection, Identification and Importance of Protein Phosphorylation

By Min Jia, Kah Wai Lin and Serhiy Souchelnytskyi


Open access peer-reviewed

13. Proteome Kinetics: Coupling the Administration of Stable Isotopes with Mass Spectrometry-Based Analyses

By Stephen F. Previs, Haihong Zhou, Sheng-Ping Wang, Kithsiri Herath, Douglas G. Johns, Thomas P. Roddy, Takhar Kasumov and Brian K. Hubbard


Open access peer-reviewed

14. Dynamics of Protein Complexes Tracked by Quantitative Proteomics

By Séverine Boulon


Open access peer-reviewed

15. Proteomics Analysis of Kinetically Stable Proteins

By Ke Xia, Marta Manning, Songjie Zhang and Wilfredo Colón


Open access peer-reviewed

16. Vinyl Sulfone: A Multi-Purpose Function in Proteomics

By F. Javier Lopez-Jaramillo, Fernando Hernandez-Mateo and Francisco Santoyo-Gonzalez


Open access peer-reviewed

17. Gel-Free Proteome Analysis Isotopic Labelling Vs. Label-Free Approaches for Quantitative Proteomics

By Baptiste Leroy, Nicolas Houyoux, Sabine Matallana-Surget and Ruddy Wattiez


Open access peer-reviewed

18. Quantitative Proteomics Using iTRAQ Labeling and Mass Spectrometry

By H. R. Fuller and G. E. Morris


Open access peer-reviewed

19. Functional Proteomics: Mapping Lipid-Protein Interactomes

By Clive D’Santos and Aurélia E. Lewis


Open access peer-reviewed

20. Protein Thiol Modification and Thiol Proteomics

By Yingxian Li, Xiaogang Wang and Qi Li


Open access peer-reviewed

21. The Utility of Mass Spectrometry Based Structural Proteomics in Biopharmaceutical Biologics Development

By Parminder Kaur and Mark R. Chance


Open access peer-reviewed

22. nwCompare and AutoCompare Softwares for Proteomics and Transcriptomics Data Mining – Application to the Exploration of Gene Expression Profiles of Aggressive Lymphomas

By Fréderic Pont, Marie Tosolini, Bernard Ycart and Jean-Jacques Fournié


Open access peer-reviewed

23. Application of Bioinformatics Tools in Gel-Based Proteomics

By Kah Wai Lin, Min Jia and Serhiy Souchelnytskyi


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI
  • BIOSIS Previews

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