Open access peer-reviewed Edited Volume

Protein-Protein Interactions

Computational and Experimental Tools


Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.

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Protein-Protein InteractionsComputational and Experimental ToolsEdited by Weibo Cai

Published: March 30th 2012

DOI: 10.5772/2679

ISBN: 978-953-51-0397-4

eBook (PDF) ISBN: 978-953-51-4312-3

Copyright year: 2012

Books open for chapter submissions

60817 Total Chapter Downloads

41 Crossref Citations

101 Web of Science Citations

105 Dimensions Citations


Open access peer-reviewed

1. Computational Methods for Prediction of Protein-Protein Interaction Sites

By Jarek Meller and Alexey Porollo


Open access peer-reviewed

2. Advances in Human-Protein Interaction - Interactive and Immersive Molecular Simulations

By Alex Tek, Matthieu Chavent, Marc Baaden, Olivier Delalande, Patrick Bourdot, Brian FG Katz and Nicolas Ferey


Open access peer-reviewed

3. Protein Interactome and Its Application to Protein Function Prediction

By Woojin Jung, Hyun-Hwan Jeong and KiYoung Lee


Open access peer-reviewed

4. Integrative Approach for Detection of Functional Modules from Protein-Protein Interaction Networks

By Zelmina Lubovac


Open access peer-reviewed

5. Mining Protein Interaction Groups

By Lusheng Wang


Open access peer-reviewed

6. Prediction of Combinatorial Protein-Protein Interaction from Expression Data Based on Conditional Probability

By Takatoshi Fujiki


Open access peer-reviewed

7. Inferring Protein-Protein Interactions (PPIs) Based on Computational Methods

By Shuichi Hirose


Open access peer-reviewed

8. Slow Protein Conformational Change, Allostery and Network Dynamics

By Fan Bai, Zhanghan Wu, Jianshi Jin, Philip Hochendoner and Jianhua Xing


Open access peer-reviewed

9. Prediction of Protein Interaction Sites Using Mimotope Analysis

By Jian Huang, Beibei Ru and Ping Dai


Open access peer-reviewed

10. Structural Bioinformatics of Proteins: Predicting the Tertiary and Quaternary Structure of Proteins from Sequence

By Baldo Oliva, Joan Planas-Iglesias, Jaume Bonet, Manuel A. Marín-López, Elisenda Feliu and Attila Gursoy


Open access peer-reviewed

11. Computational Approaches to Predict Protein Interaction

By Tien-Hao Chang


Open access peer-reviewed

12. G-Protein Coupled Receptors: Experimental and Computational Approaches

By Amirhossein Sakhteman, Hamid Nadri and Alireza Moradi


Open access peer-reviewed

13. Computational Approaches to Elucidating Transient Protein-Protein Interactions, Predicting Receptor-Ligand Pairings

By Ernesto Iacucci, Samuel Xavier De Souza and Yves Moreau


Open access peer-reviewed

14. Finding Protein Complexes via Fuzzy Learning Vector Quantization Algorithm

By Hamid Ravaee


Open access peer-reviewed

15. In Vivo Imaging of Protein-Protein Interactions

By Weibo Cai


Open access peer-reviewed

16. NMR Investigations on Ruggedness of Native State Energy Landscape in Folded Proteins

By Maruthi Krishna Mohan Poluri


Open access peer-reviewed

17. Conformational and Disorder to Order Transitions in Proteins: Structure / Function Correlation in Apolipoproteins

By José Campos-Terán, Paola Mendoza Espinosa, Jaime Mas and Rolando Castillo


Open access peer-reviewed

18. Protein-Protein Interactions in Salt Solutions

By Jifeng Zhang


Open access peer-reviewed

19. Computational Tools and Databases for the Study and Characterization of Protein Interactions

By Joan Segura, Jose Ramon Blas Pastor and Narcis Fernandez-Fuentes


Open access peer-reviewed

20. Protein-Protein Interaction Networks: Structures, Evolution, and Application to Drug Design

By Takeshi Hase and Yoshihito Niimura


Open access peer-reviewed

21. A Survey on Evolutionary Analysis in PPI Networks

By Pavol Jancura and Elena Marchiori


Open access peer-reviewed

22. Scalable, Integrative Analysis and Visualization of Protein Interactions

By David Otasek, Chiara Pastrello and Igor Jurisica


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI
  • BIOSIS Previews

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