Open access peer-reviewed Edited Volume

Gene Expression

Fumiaki Uchiumi

Tokyo University of Science

Researcher and educator in molecular biology and biological chemistry, chairman of the genetic engineering safety committee of Tokyo University of Science.


Transcription Factors R-Loop RNA Splicing Epigenetic Regulation circRNA miRNA lncRNA ncRNA Extrachromosomal Circular DNAs Transposable Elements Aging Related Diseases Cancer

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About the book

Gene expression is a fundamental biological reaction in both eukaryotes and prokaryotes. It could be said that gene expression is just dependent on the process of how mature RNAs are made, but the mechanism is very much complicated. For example, initiation of transcription is executed by multiple proteins, including specific DNA-sequence recognizing transcription factors and RNA polymerases. Therefore, it is dependent on DNA elements that are present within promoters, enhancers, or terminators of some genes. R-loop formation and RNA splicing can also affect gene expression. Gene expression in eukaryotic cells is regulated epigenetically by DNA methylation, histone modifications, and poly(ADP-ribosyl)ation. Moreover, recent studies have shown that transposable elements, including retrotransposons, LINEs, and SINEs in the human genome affect gene expression systems.

The book will cover a review of the fundamental mechanisms of gene expression from various aspects. Also, it would be discussed how human diseases are caused by the dysregulation of gene expression, and how they should be treated with novel therapies that control gene expression.

Publishing process

Book initiated and editor appointed

Date completed: September 29th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: October 27th 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: December 26th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 16th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 15th 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Fumiaki Uchiumi

Tokyo University of Science

Fumiaki Uchiumi, Professor of Pharmaceutical Sciences, Tokyo University of Science, received his Bachelor\'s degree (Chemistry) from Tokyo University of Science in 1987. In 1993, after obtaining his Ph.D. degree (Molecular Biology) from Tokyo University, he joined Professor S. Tanuma\'s Laboratory at Tokyo University of Science as an Assistant Professor. He obtained his second Ph.D. (Pharmaceutical Science) from Tokyo University of Science in 1999 and in 2000 was promoted to the position of Lecturer at Tokyo University of Science. Professor Uchiumi then went abroad as a post-doctoral researcher for the United States-Japan Cooperative Cancer Research Program in Professor E. Fanning’s Laboratory at Vanderbilt University, 2000-2001. Professor Uchiumi was promoted to Associate Professor and then Full Professor at Tokyo University of Science in 2010 and 2016, respectively.

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Book chapters authored 6

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