About the book
Gene expression is a fundamental biological reaction in both eukaryotes and prokaryotes. It could be said that gene expression is just dependent on the process of how mature RNAs are made, but the mechanism is very much complicated. For example, initiation of transcription is executed by multiple proteins, including specific DNA-sequence recognizing transcription factors and RNA polymerases. Therefore, it is dependent on DNA elements that are present within promoters, enhancers, or terminators of some genes. R-loop formation and RNA splicing can also affect gene expression. Gene expression in eukaryotic cells is regulated epigenetically by DNA methylation, histone modifications, and poly(ADP-ribosyl)ation. Moreover, recent studies have shown that transposable elements, including retrotransposons, LINEs, and SINEs in the human genome affect gene expression systems.
The book will cover a review of the fundamental mechanisms of gene expression from various aspects. Also, it would be discussed how human diseases are caused by the dysregulation of gene expression, and how they should be treated with novel therapies that control gene expression.