Open access peer-reviewed Edited Volume


Antonio Ibarra

Universidad Anáhuac


Carlos Cuellar

Universidad Anáhuac


Exoskeletons spinal cord injury Cell-based therapy stem cells Schwann cells mesenchymal stem cells Bioavailability volume distribution pharmacokinetics Physiotherapy rehabilitation mobility sensation posture Neuromodulation Electrical stimulation muscle function Autonomic dysfunctions

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About the book

Although promising results derived from clinical trials have drawn attention from patients and clinicians, paraplegia resulting from traumatic spinal cord injury (tSCI) hasn't got a cure to date. Pathophysiological complexity, degeneration processes and heterogeneity of lesions embody a major challenge. Additionally, treatments to mitigate motor, sensory and autonomic dysfunctions are not currently available. However, multidisciplinary, cutting-edge studies have made significant progress to restore the loss of physiological functions due to tSCI.

In the present book “Paraplegia”, prolific and renowned scientists discuss approaches that have shown benefits in human subjects. While cell-based therapies and immune modulators are still far from clinic, knowledge derived from innovative research is pursuing the regeneration of damaged tissue as reported in human trials. Neuromodulation in combination with physical therapy are emerging therapies essentially aimed to enable motor function, fortunately, autonomic dysfunctions, and are recognized by patients as a priority for restoration, which also has benefits from these strategies. Finally, the use of orthotic devices such as exoskeletons, which have exhibited improvement in motor performance, are mentioned. Even though a few, well executed and scientifically driven studies are available, they offer enough evidence to think on the development of treatments aimed to mitigate the consequences of tSCI. A combination of biomedical and bioengineering sciences, and more importantly the joint effort of a community of experts, provide a brighter scenario nowadays.

Publishing process

Book initiated and editor appointed

Date completed: October 16th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: January 5th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 25th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 24th 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Antonio Ibarra

Universidad Anáhuac

Dr. Antonio Ibarra is a Professor and Researcher of the Faculty of Health Sciences at the Universidad Anáhuac. He earned a Master and Doctorate in Sciences and based his thesis on the development of neuroprotective strategies. As a post-doctoral fellow at the Weizmann Institute of Science, and later as scientist, he has studied the beneficial effects induced by protective autoimmunity after spinal cord injury. The focus of his research has been the development of neuroprotective and neuroregenerative strategies. Using spinal cord injury models Dr. Ibarra has published numerous articles and book chapters on spinal cord injury. His findings led Dr. Ibarra to lecture in diverse international Meetings. In addition, he is Editor and reviewer of several international journals. Dr. Ibarra is a member of the Mexican Research System, Level II.

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