About the book
Although promising results derived from clinical trials have drawn attention from patients and clinicians, paraplegia resulting from traumatic spinal cord injury (tSCI) hasn't got a cure to date. Pathophysiological complexity, degeneration processes and heterogeneity of lesions embody a major challenge. Additionally, treatments to mitigate motor, sensory and autonomic dysfunctions are not currently available. However, multidisciplinary, cutting-edge studies have made significant progress to restore the loss of physiological functions due to tSCI.
In the present book “Paraplegia”, prolific and renowned scientists discuss approaches that have shown benefits in human subjects. While cell-based therapies and immune modulators are still far from clinic, knowledge derived from innovative research is pursuing the regeneration of damaged tissue as reported in human trials. Neuromodulation in combination with physical therapy are emerging therapies essentially aimed to enable motor function, fortunately, autonomic dysfunctions, and are recognized by patients as a priority for restoration, which also has benefits from these strategies. Finally, the use of orthotic devices such as exoskeletons, which have exhibited improvement in motor performance, are mentioned. Even though a few, well executed and scientifically driven studies are available, they offer enough evidence to think on the development of treatments aimed to mitigate the consequences of tSCI. A combination of biomedical and bioengineering sciences, and more importantly the joint effort of a community of experts, provide a brighter scenario nowadays.