About the book
Vitamin K, one of fat-soluble vitamins, works as a cofactor of γ-glutamyl carboxylase for activation of blood coagulation factors and bone proteins. Other than this well-known function of vitamin K, this vitamin plays crucial roles in various cellular functions including differentiation, proliferation, apoptosis, and metabolism via modulating intracellular signaling. Menaquinone-4, that is one of vitamin K2 analogues, is endobiotic synthesized from other types of vitamin K after absorption from intestine and has unique properties. For example, menaquinone-4 binds to of nuclear receptor NR1I2 (also called PXR or SXR) and modulates the expression of certain genes involved in not only drug metabolism, but also energy metabolism and inflammation. Natural isoprenoid geranylgeraniol, that is side chain moiety of menaquinone-4, and structurally mimetic compounds also have similar functions to menaquinone-4.
In this book, we focus on recent advances and new perspectives on vitamin K research that can contribute to health promotion and prevention of diseases.