Open access peer-reviewed Edited Volume

Vitamin K - Recent Advances, New Perspectives and Applications for Human Health

Hiroyuki Kagechika

Tokyo Medical and Dental University

A Director of Tokyo Medical and Dental University (TMDU), Institute of Biomaterials and Bioengineering whose major research interest is the medicinal chemistry of hydrophobic signalling molecules, including specific modulators of the various nuclear receptor.


Hitoshi Shirakawa

Tohoku University

A Researcher in nutrition and molecular biology and an appointed Professor from Tohoku University, Japan.


Osteocalcin Matrix Gla Protein NR1l2 PXR SXR Structurally Mimetic Compounds Isoprenoids Mevalonate Pathway Intracellular Signalling UBIAD1 Menaquinone-4 Prenyltransferase

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About the book

Vitamin K, one of fat-soluble vitamins, works as a cofactor of γ-glutamyl carboxylase for activation of blood coagulation factors and bone proteins. Other than this well-known function of vitamin K, this vitamin plays crucial roles in various cellular functions including differentiation, proliferation, apoptosis, and metabolism via modulating intracellular signaling. Menaquinone-4, that is one of vitamin K2 analogues, is endobiotic synthesized from other types of vitamin K after absorption from intestine and has unique properties. For example, menaquinone-4 binds to of nuclear receptor NR1I2 (also called PXR or SXR) and modulates the expression of certain genes involved in not only drug metabolism, but also energy metabolism and inflammation. Natural isoprenoid geranylgeraniol, that is side chain moiety of menaquinone-4, and structurally mimetic compounds also have similar functions to menaquinone-4.

In this book, we focus on recent advances and new perspectives on vitamin K research that can contribute to health promotion and prevention of diseases.

Publishing process

Book initiated and editor appointed

Date completed: November 26th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

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Approved chapters written in full and submitted

Deadline for full chapters: February 22nd 2021

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Full chapters peer reviewed

Review results due: May 13th 2021

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Expected publication date: July 12th 2021

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About the editor

Hiroyuki Kagechika

Tokyo Medical and Dental University

Hiroyuki Kagechika received his Bachelor and Ph.D. degrees from The University of Tokyo (Pharmaceutical Sciences), Japan, in 1989 and was an Associate Professor at the same university until 2004. Then he moved to Tokyo Medical and Dental University (TMDU), where he is currently a Professor in Institute of Biomaetrials and Bioengineering (IBB). From 2010-2015, he was appointed as the Dean of Graduate School of Biomedical Science, and since 2012, as the Vice Dean of Graduate School of Medical and Dental Sciences. From 2020, he was was appointed as the Director of Institute of Biomaterials and Bioengineering (IBB). He is the author of over 280 scientific publications. His major research interest is the medicinal chemistry of nuclear receptors, such as retinoid, vitamin D, steroid hormone receptors, as well as the orphan receptors, and developed various specific ligands by using novel and unique pharmacophore and bioisosters, including a drug for acute promyelocytic leukemia. He is also interested in the chemistry of aromatic amides with unique structures, which is useful for construction of functional aromatic molecules. He received several awards such as The Pharmaceutical Society of Japan (PSJ) Award for Young Scientists (1994), The Pharmaceutical Society of Japan (PSJ) Award for Drug Research and Development (2006), The Japanese Cancer Association-Chugai Academy for Advanced Oncology Award (2015), and The Vitamin Society of Japan Award (2016). Recently, he is a coordinator foe JSPS core-to-core program for Center of international research platform for biomedical science and drug discovery against intractable diseases.

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