Open access peer-reviewed Edited volume

Protein Phosphorylation

Protein phosphorylation reactions are carried out in a cell by protein kinases, which predominantly use ATP as a phosphate donor that is transferred and covalently bound to an amino acid on a substrate protein. Protein phosphorylation was discovered in 1954 by Edmond Fischer who shared the Nobel Prize in Medicine or Physiology in 1992 with Edwin Krebs. There are so many kinases that one was called "Just Another Kinase" for JAK kinase. Their counterpart is protein phosphatases that remove phosphates from phosphorylated proteins. Kinases and phosphatases act as switches in the cell that activates or inactivates protein functions. These reactions are reversible; the cell can quickly react to a situation but can then go back to its initial state.

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Protein PhosphorylationEdited by Claude Prigent

Published: November 29th 2017

DOI: 10.5772/65615

ISBN: 978-953-51-3626-2

Print ISBN: 978-953-51-3625-5

Books open for chapter submissions

1575 Total Chapter Downloads

chaptersDownloads

Open access peer-reviewed

1. ARPP19 Phosphorylations by PKA and Greatwall: The Yin and the Yang of the Cell Decision to Divide

By Aude Dupré and Catherine Jessus

181

Open access peer-reviewed

2. The Mitotic Protein Kinase Haspin and Its Inhibitors

By Omid Feizbakhsh, Matthieu Place, Xavier Fant, Frédéric Buron, Sylvain Routier and Sandrine Ruchaud

215

Open access peer-reviewed

3. Regulation of Aurora Kinases and Their Activity

By Lucie Vaufrey, Arun Prasath Damodaran, Olivia Gavard, Stéphanie Le Bras and Claude Prigent

193

Open access peer-reviewed

4. Biological Consequences of Priming Phosphorylation in Cancer Development

By Katsuhiko Aoki and Kiyotsugu Yoshida

167

Open access peer-reviewed

5. Phosphorylation-Mediated Control of Stress Responses Induced by Nanosecond Pulsed Electric Fields

By Ken-ichi Yano and Keiko Morotomi-Yano

164

Open access peer-reviewed

6. Modification of α-Synuclein by Phosphorylation: A Pivotal Event in the Cellular Pathogenesis of Parkinson’s Disease

By Indrani Datta and Kavina Ganapathy

161

Open access peer-reviewed

7. Ecto-Phosphorylation and Regeneration of the Adult Central Nervous System

By Yoshinori Takei and Yoko Amagase

139

Open access peer-reviewed

8. Computational Modeling of Complex Protein Activity Networks

By Stefano Schivo, Jeroen Leijten, Marcel Karperien and Janine N. Post

161

Open access peer-reviewed

9. FRET-Based Biosensors: Genetically Encoded Tools to Track Kinase Activity in Living Cells

By Florian Sizaire and Marc Tramier

194

Edited volume and chapters are indexed in

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  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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