Open access peer-reviewed Edited Volume


Edited by Anca Pantea Stoian

Carol Davila University of Medicine and Pharmacy


Manfredi Rizzo

University of Palermo

The book “Metformin” aims to bring to light new concepts and trends related to the many metformin therapeutic features. After a history of over 60 years, with moments of decline and spectacular returns, metformin can now be regarded as a universal panacea, the valences of its therapeutics being increasingly appreciated, both in the background treatment of diabetes and pre-diabetes, but also in reproductive pathology, cancer, cardiovascular disease, and antiageing. In this respect, the mechanisms of action and the pharmacodynamics of metformin seem to be incompletely known, a number of current studies have revealed new action valences.

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MetforminEdited by Anca Pantea Stoian

Published: May 27th 2020

DOI: 10.5772/intechopen.77824

ISBN: 978-1-83880-428-2

Print ISBN: 978-1-83880-427-5

eBook (PDF) ISBN: 978-1-83880-760-3

Copyright year: 2020

Books open for chapter submissions

5226 Total Chapter Downloads

5 Crossref Citations

2 Web of Science Citations

10 Dimensions Citations


Open access peer-reviewed

1. Metformin Indications, Dosage, Adverse Reactions, and Contraindications

By Roxana Adriana Stoica, Diana Simona Ștefan, Manfredi Rizzo, Andra Iulia Suceveanu, Adrian Paul Suceveanu, Cristian Serafinceanu and Anca Pantea-Stoian


Open access peer-reviewed

2. New Insight into Metformin Mechanism of Action and Clinical Application

By Yun Yan, Karen L. Kover and Wayne V. Moore


Open access peer-reviewed

3. Metformin and Its Benefits in Improving Gut Microbiota Disturbances in Diabetes Patients

By Andra Iulia-Suceveanu, Sergiu Ioan Micu, Claudia Voinea, Madalina Elena Manea, Doina Catrinoiu, Laura Mazilu, Anca Pantea Stoian, Irinel Parepa, Roxana Adriana Stoica and Adrian-Paul Suceveanu


Open access peer-reviewed

4. Potential Protective Effects of Metformin on Ocular Complications in Patients with Type 2 Diabetes

By Jasna Kusturica, Aida Kulo, Maida Rakanović-Todić, Lejla Burnazović-Ristić and Sanita Maleškić


Open access peer-reviewed

5. Galega officinalis L. and Immunological Status in Diabetes Mellitus

By Mariia Nagalievska, Halyna Hachkova and Nataliia Sybirna


Open access peer-reviewed

6. Metformin in Health Issues and Reproductive System

By Elham Pourmatroud


Open access peer-reviewed

7. Metformin and Its Implication in Cancer Therapy

By Laura Mazilu, Dana Stanculeanu, Andreea Gheorghe, Adrian-Paul Suceveanu, Irinel Parepa, Felix Voinea, Doina Catrinoiu and Andra-Iulia Suceveanu


Open access peer-reviewed

8. Preventive and (Neo)Adjuvant Therapeutic Effects of Metformin on Cancer

By Yile Jiao, Xiaochen Wang and Zhijun Luo


Open access peer-reviewed

9. Metformin in Cervical Cancer: Metabolic Reprogramming

By Malgorzata Tyszka-Czochara and Marcin Majka


Open access peer-reviewed

10. Antitumoral Effects of Metformin in Ovarian Cancer

By Maritza P. Garrido, Margarita Vega and Carmen Romero


Open access peer-reviewed

11. Metformin Activity against Breast Cancer: Mechanistic Differences by Molecular Subtype and Metabolic Conditions

By Reema S. Wahdan-Alaswad and Ann D. Thor


Open access peer-reviewed

12. Metformin Modulates the Mechanisms of Ageing

By Adriana Florinela Cӑtoi, Andra Diana Andreicuț, Dan Cristian Vodnar, Katalin Szabo, Andreea Corina, Andreea Arsene, Simona Diana Stefan, Roxana Adriana Stoica and Manfredi Rizzo


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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