Open access peer-reviewed Edited Volume

Human Skin Cancer, Potential Biomarkers and Therapeutic Targets

Edited by Miroslav Blumenberg

New York University Medical School

Skin cancers, basal and squamous cell carcinomas, malignant melanomas, and Merkel cell carcinomas, constitute arguably the most common and increasingly prevalent human neoplasms. Here we discuss the epigenetic changes in DNA and chromatin, which are increasingly associated with melanoma. Several chapters focus on the posttranscriptional modification of the proteins at the melanocyte cell surface, their role in tumorigenesis, and their potential as therapeutic targets. Specifically, extracellular modifications of integrins, glycosylation of cell surface proteins, and changes of cadherins are presented. In a very interesting approach, a potential to target the mitochondria of melanoma cells is investigated. In conclusion, this volume presents various aspects of human skin cancers, components of the large worldwide effort to combat and eradicate this growing health concern.

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Human Skin Cancer, Potential Biomarkers and Therapeutic TargetsEdited by Miroslav Blumenberg

Published: October 19th 2016

DOI: 10.5772/61922

ISBN: 978-953-51-2711-6

Print ISBN: 978-953-51-2710-9

Copyright year: 2016

Books open for chapter submissions

3269 Total Chapter Downloads

1 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Introductory Chapter: A Short Primer on Human Skin Cancers

By Miroslav Blumenberg

446

Open access peer-reviewed

2. The Emerging Epigenetic Landscape in Melanoma

By Robert A. Rollins, Kimberly H. Kim and Cheng‐Chung Tsao

605

Open access peer-reviewed

3. Glycosylation of Integrins in Melanoma Progression

By Ewa Pocheć and Anna Lityńska

634

Open access peer-reviewed

4. Bitter Sweetness of Malignant Melanoma: Deciphering the Role of Cell Surface Glycosylation in Tumour Progression and Metastasis

By Małgorzata Przybyło, Marcelina E. Janik and Dorota Hoja-Łukowicz

483

Open access peer-reviewed

5. Cadherins and their Role in Malignant Transformation: Implications for Skin Cancer Progression

By Marcelina E. Janik, Dorota Hoja-Łukowicz and Małgorzata Przybyło

448

Open access peer-reviewed

6. Inhibiting Lactate Dehydrogenase A Enhances the Cytotoxicity of the Mitochondria Accumulating Antioxidant, Mitoquinone, in Melanoma Cells

By Ali A. Alshamrani, James L. Franklin, Aaron M. Beedle and Mandi M. Murph

653

Edited Volume and chapters are indexed in

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  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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