Open access peer-reviewed Edited Volume

Breakthroughs in Melanoma Research

Melanoma is considered to be one of the most aggressive forms of skin neoplasms. Despite aggressive researches towards finding treatments, no effective therapy exists to inhibit the metastatic spread of malignant melanoma. The 5-year survival rate of metastatic melanoma is still significantly low, and there has been an earnest need to develop more effective therapies with greater anti-melanoma activity. Through the accomplishment of over 100 distinguished and respected researchers from 19 different countries, this book covers a wide range of aspects from various standpoints and issues related to melanoma. These include the biology of melanoma, pigmentations, pathways, receptors and diagnosis, and the latest treatments and therapies to make potential new therapies. Not only will this be beneficial for readers, but it will also contribute to scientists making further breakthroughs in melanoma research.

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Breakthroughs in Melanoma ResearchEdited by Yohei Tanaka

Published: November 14th 2011

DOI: 10.5772/795

ISBN: 978-953-307-291-3

eBook (PDF) ISBN: 978-953-51-6564-4

Copyright year: 2011

Books open for chapter submissions

61811 Total Chapter Downloads

25 Crossref Citations

33 Web of Science Citations

47 Dimensions Citations


Open access peer-reviewed

1. Reactive Oxygen Species in the Biology of Melanoma

By Irene L. Ibañez, Cintia Notcovich, Lucía L. Policastro and Hebe Durán


Open access peer-reviewed

2. The Role of the Microenvironment – Models for the Study of Melanoma

By Lucia Speroni, Victoria de los Angeles Bustuoabad, Julieta Gasparri, Nadia Silvia Chiaramoni and Silvia del Valle Alonso


Open access peer-reviewed

3. Circulating Melanoma Cells

By Mel Ziman


Open access peer-reviewed

4. Regulation of the Glutathione S-Transferase P1 Expression in Melanoma Cells

By Andrii Slonchak, Agata Chwieduk, Joanna Rzeszowska-Wolny and Maria Obolenskaya


Open access peer-reviewed

5. Changing the Nature of Melanoma Cells by Manipulation of Ganglioside Expression

By Pu Wang, Sadako Yamagata and Tatsuya Yamagata


Open access peer-reviewed

6. Melanoma Cell Factory for Glycolipid Production

By Maria Carmelita Z. Kasuya and Kenichi Hatanaka


Open access peer-reviewed

7. Melanoma-Induced Endothelial Cell Growth Involves Phospholipase A2 and COX2 Upregulation

By Mario Alberghina, Carla Motta, Gabriella Lupo, Carmelina D. Anfuso and Renato Bernardini


Open access peer-reviewed

8. Pigment Epithelium-Derived Factor – An Angiostatic Factor with a Broader Function in Melanoma

By A. Fernández-Barral, J.L. Orgaz and B. Jiménez


Open access peer-reviewed

9. The Influence of the Skin Microenvironment Air-Liquid Interface on Melanoma

By Shuji Toda, Shigehisa Aoki, Kazuyoshi Uchihashi, Aki Matsunobu, Mai Yakushiji, Akifumi Ootani, Eisuke Koike and Nobuhisa Yonemitsu


Open access peer-reviewed

10. Melanocyte Pygmentation – Friend or Foe on the Route to Melanoma

By Baldea Ioana


Open access peer-reviewed

11. Melanin and Its Role in Hyper-Pigmentation – Current Knowledge and Future Trends in Research

By Manyatja Brenda Mapunya and Namrita Lall


Open access peer-reviewed

12. Genomics of Human Malignant Melanoma

By Margit Balázs, Szilvia Ecsedi, Laura Vízkeleti and Ágnes Bégány


Open access peer-reviewed

13. Melanoma and the Nervous System – Novel Pathways Mediated by Neurotrophins and Their Receptors

By Carlo Pincelli, Katiuscia Dallaglio and Francesca Truzzi


Open access peer-reviewed

14. The Jak-STAT Signal Transduction Pathway in Melanoma

By Courtney Nicholas and Gregory B. Lesinski


Open access peer-reviewed

15. Targeting Adenosine Receptors for the Treatment of Melanoma

By Sarvesh Jajoo, Sandeep Sheth, Debashree Mukherjea, Leonard P. Rybak and Vickram Ramkumar


Open access peer-reviewed

16. The Roles of S100 Proteins and RAGE in Melanoma

By Estelle Leclerc


Open access peer-reviewed

17. Understanding Melanocyte Transformation – A Work in Progress

By Janet Wangari-Talbot, James Goydos and Suzie Chen


Open access peer-reviewed

18. Biomarkers for Melanoma Diagnosis and the Technologies Used to Identify Them

By Takeshi Mori and Jeong-Hun Kang


Open access peer-reviewed

19. Characterization of Melanoma Progression on Animal Model Using Fourier Transform Infrared Mapping

By Beljebbar A., Gatouillat G., Morjani H., Manfait M. and Madoulet C.


Open access peer-reviewed

20. Ion Channels as Promising Therapeutic Targets for Melanoma

By Aurélie Chantôme, Marie Potier-Cartereau, Sébastien Roger, Christophe Vandier, Olivier Soriani and Virginie Joulin


Open access peer-reviewed

21. Targeting the Proteasome in Melanoma

By Anabel Sorolla, Andree Yeramian, Xavier Dolcet, Leandro Abal, Eugenia Ortega, Ramon Egido, Xavier Matias-Guiu and Rosa M. Marti


Open access peer-reviewed

22. Nuclear Translocation of YB-1 Protein Induced by Ultraviolet Light and the Investigational Gallium Drug GaQ3 in Melanoma Cells

By Seied Mojtaba Valiahdi, Michael A. Jakupec, Sara Daraei, Franz Wohlrab and Bernhard K. Keppler


Open access peer-reviewed

23. Novel Approach to the Characterization of Melanoma Associated-Peptide-Specific CTL Lines from Melanoma Patients

By Yasuto Akiyama, Masaru Komiyama, Akira Iizuka, Akifumi Yamamoto, Naoya Yamazaki and Yoshio Kiyohara


Open access peer-reviewed

24. Quantitative Regulation of Melanoma Growth in the Host by Tumor-Specific Serpins in Blood Serum is a Main Reason for Inefficient Tumor Treatment

By Donenko F. V., Kiselevskii M.V. and Efferth T.


Open access peer-reviewed

25. Molecular Profiling of A375 Human Malignant Melanoma Cells Treated with Kojic Acid and Arbutin

By Jung-Feng Hsieh, Shui-Tein Chen and Sun-Long Cheng


Open access peer-reviewed

26. Anticancer Effects of a Micronutrient Mixture on Melanoma – Modulation of Metastasis and Other Critical Parameters

By M.W. Roomi, T. Kalinovsky, A. Niedzwiecki and M. Rath


Open access peer-reviewed

27. RANK/RANKL Axis in Melanoma

By Kanji Mori, Kosei Ando, Frédéric Lézot and Dominique Heymann


Open access peer-reviewed

28. Isolation of Cellular Clones of Murine Melanoma Resistants to the Photodynamic Therapy and Characterization of Some Mechanisms Involved in the Radioresistance

By Ramón-Gallegos E., Rosas-Flores L., Barrera-Mendoza C.C., Herrera-Carrillo Z., González-Agüero G., Estrada-Manrique G. and Cruz-Orea A.


Open access peer-reviewed

29. Non-Thermal Effects of Near-Infrared Irradiation on Melanoma

By Yohei Tanaka and Kiyoshi Matsuo


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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