Open access peer-reviewed Edited Volume


Carcinogenesis covers molecular, biochemical and cellular processes that underpin this field. The complex nature of cancer means that a broad understanding of these processes is advantageous when designing novel preventative, therapeutic or diagnostic strategies. This book commences with chapters discussing cancer predisposition and pre-cancerous lesions. Factors that initiate or progress cancer development, including viral, hormonal, oncogenic and biochemical stimuli are then described, as are interactions with the cancer extracellular environment. Animal models are particularly useful for evaluating therapeutic or chemopreventive agents and examples are presented. Finally, natural products that ether prevent or treat cancer are described. Together these topics will provide the reader with examples of the latest cutting edge research and discoveries, with the goal of stimulating further advances.

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CarcinogenesisEdited by Kathryn Tonissen

Published: January 23rd 2013

DOI: 10.5772/2982

ISBN: 978-953-51-0945-7

eBook (PDF) ISBN: 978-953-51-7075-4

Copyright year: 2013

Books open for chapter submissions

31632 Total Chapter Downloads

11 Crossref Citations

18 Web of Science Citations

33 Dimensions Citations


Open access peer-reviewed

1. Synergistic Effects of Low-Risk Variant Alleles in Cancer Predisposition

By Francesca Duraturo, Raffaella Liccardo, Angela Cavallo, Marina De Rosa and Paola Izzo


Open access peer-reviewed

2. Binary System of Grading Epithelial Dysplasia in Oral Leukoplakias

By Maria Auxiliadora Vieira do Carmo and Patrícia Carlos Caldeira


Open access peer-reviewed

3. Human Papillomavirus and Carcinogenesis in the Upper Aero-Digestive Tract

By Andrés Castillo


Open access peer-reviewed

4. Oestrogens, Xenoestrogens and Hormone-Dependent Cancers

By Anna Ptak and Ewa Lucja Gregoraszczuk


Open access peer-reviewed

5. EPS8, an Adaptor Protein Acts as an Oncoprotein in Human Cancer

By Ming-Chei Maa and Tzeng-Horng Leu


Open access peer-reviewed

6. FJ194940.1 Gene and Its Protein Product ACJ04040.1 – Potential Tumor Marker – From Protein to cDNA and Chromosomal Localization

By Ewa Balcerczak, Aleksandra Sałagacka, Malwina Bartczak-Tomczyk and Marek Mirowski


Open access peer-reviewed

7. The Interaction Between Redox and Hypoxic Signalling Pathways in the Dynamic Oxygen Environment of Cancer Cells

By Maneet Bhatia, Therese C. Karlenius, Giovanna Di Trapani and Kathryn F. Tonissen


Open access peer-reviewed

8. Expressional Alterations of Versican, Hyaluronan and Microfibril Associated Proteins in the Cancer Microenvironment

By Hiroko Kuwabara, Masahiko Yoneda and Zenzo Isogai


Open access peer-reviewed

9. Molecular Mechanisms of Metastasis: Epithelial-Mesenchymal Transition, Anoikis and Loss of Adhesion

By M.E. Hernández-Caballero


Open access peer-reviewed

10. Lobe-Specific Carcinogenesis in the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mouse Model

By Jinhui Zhang, Lei Wang, Yong Zhang and Junxuan Lu


Open access peer-reviewed

11. Mechanism of Urinary Bladder Carcinogenesis Induced by a Xanthine Oxidoreductase Inhibitor, in Rats

By Naoki Naoki Ashizawa and Takeo Shimo


Open access peer-reviewed

12. Cancer Chemoprevention by Dietary Polyphenols

By Magdy Sayed Aly and Amani Abd ElHamid Mahmoud


Open access peer-reviewed

13. Kuguacin J, a Triterpenoid from Momordica charantia Linn: A Comprehensive Review of Anticarcinogenic Properties

By Pornngarm Limtrakul, Pornsiri Pitchakarn and Shugo Suzuki


Open access peer-reviewed

14. Regulation of Apoptosis, Invasion and Angiogenesis of Tumor Cells by Caffeic Acid Phenethyl Ester

By Mohamed F. El-Refaei and Essam A. Mady


Edited Volume and chapters are indexed in

  • Worldcat
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  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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