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Dmitry Bulgin

Dmitry Bulgin received his MD and PhD degrees from Smolensk State Medical University in 1998 and 2004, respectively. He served as an Assistant Professor at the Department of Pathology in Smolensk State Medical University from 2000 to 2004. Between 2004 and 2006, he has been a visiting researcher at the Department of Molecular Medicine of Atomic Bomb Disease Institute in Nagasaki University Graduate School of Biomedical Sciences. Since 2006, he was appointed as a Chairman of the Department of Laboratory Medicine at Pokrovskaya Municipal Hospital in Saint Petersburg, Russia. From 2010, he served as a principal research scientist and general practitioner at the Center for Regenerative Medicine ME-DENT in Rovinj, Croatia. He is a member of professional associations such as Croatian Medical Chamber, European Society of Pathology, European Society for Artificial Organs, The Transplantation Society, European Radiation Research Society, and Tissue Engineering and Regenerative Medicine International Society. His research interests include Cancer Research, Stem Cell Biology, Molecular Medicine, Ionizing Radiation, and Tissue Regeneration.

1books edited

2chapters authored

Latest work with IntechOpen by Dmitry Bulgin

Written by an international team of experts in the field of human carcinogenesis, this book discusses recent advances in cancer research, which include the following topics: basic molecular and cellular mechanisms behind cancer growth, new approaches in cancer therapy, and cancer diagnostic. The book serves as a useful source of reference for cancer biologists, medical doctors, and clinical researchers in the fields of cancer diagnosis, prevention, and treatment.

New Aspects in Molecular and Cellular Mechanisms of Human Carcinogenesis

New Aspects in Molecular and Cellular Mechanisms of Human Carcinogenesis

Edited by Dmitry Bulgin

Chapters authored

Pharmacological Inhibition of Intracellular Signaling Pathways in Radioresistant Anaplastic Thyroid Cancer

By Dmitry Bulgin and Alexey Podcheko

Anaplastic thyroid cancer (ATC) is highly aggressive and has a poor therapeutic response and leads to high mortality. It has been shown that activation of intracellular c-Jun N-terminal kinase (JNK) and c-ABL signaling pathways is one of the manifestations of the highly resistant response to radiotherapy in ATC. Pharmacological inhibition of these pathways in combination with radiotherapy is a potential treatment modality of ATC.

Part of the book: New Aspects in Molecular and Cellular Mechanisms of Human Carcinogenesis

Modern Technologies for Timely Detection and Differential Diagnosis of Gastric Cancer

By Vladimir Levkin, Nina Gagarina, Sergey Kharnas, Gaziyav Musaev, Artem Shiryaev and Dmitry Bulgin

The diagnostic potentialities of laser spectro- and videofluorescence endoscopy, complex transabdominal US examination, dynamic multihelical computed tomography (MHCT) with the possibility of constructing multiplanar reformations, and virtual gastroscopy were studied with a view to diagnosing gastric cancer (GC). It was established that laser spectral fluorescence with the drug Alasens (5-aminolevulinic acid) is a highly revealing method for diagnosis and differential diagnosis of GC. The sensitivity of the method is 96%, and its specificity is 78%. Well-defined videofluorescence was noted in 91.3% of patients with GC. The possibility of detecting cancer with complex trans-ultrasonography in the pyloroantral division and in the lower third of the body of the stomach constitutes 95.6% attaining absolute values in T3 and T4. Dynamic MHCT allows 97% detection of GC attaining absolute values, beginning with T2 invasion depth; tumor localization is irrelevant. Comparative visual assessment of the quality of a virtual image and conventional video esophagogastroduodenoscopy (EGDS) was made. The study demonstrated a sufficiently high level of virtual images whose quality was not inferior to that of conventional images in intraluminal tumor growth. The indications for the application of this technique require further specification.

Part of the book: New Aspects in Molecular and Cellular Mechanisms of Human Carcinogenesis

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