Open access peer-reviewed Edited Volume

Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications

Edited by Terry Lichtor

Rush University Medical Center, United States of America

A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.

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Evolution of the Molecular Biology of Brain Tumors and the Therapeutic ImplicationsEdited by Terry Lichtor

Published: February 27th 2013

DOI: 10.5772/50198

ISBN: 978-953-51-0989-1

eBook (PDF) ISBN: 978-953-51-7099-0

Copyright year: 2013

Books open for chapter submissions

42119 Total Chapter Downloads

19 Crossref Citations

36 Web of Science Citations

51 Dimensions Citations


Open access peer-reviewed

1. Brain Tumor Invasion and Angiogenesis

By Almos Klekner


Open access peer-reviewed

2. Gliomas Biology: Angiogenesis and Invasion

By Maria Caffo, Valeria Barresi, Gerardo Caruso, Giuseppe La Fata, Maria Angela Pino, Giuseppe Raudino, Concetta Alafaci and Francesco Tomasello


Open access peer-reviewed

3. Hypoxia, Angiogenesis and Mechanisms for Invasion of Malignant Gliomas

By Paula Province, Corinne E. Griguer, Xiaosi Han, Nabors Louis B. and Hassan Fathallah Shaykh


Open access peer-reviewed

4. Brain Tumor–Induced Angiogenesis: Approaches and Bioassays

By Stefan W. Hock, Zheng Fan, Michael Buchfelder, Ilker Y. Eyüpoglu and Nic E. Savaskan


Open access peer-reviewed

5. IGF-I Antisense and Triple-Helix Gene Therapy of Glioblastoma

By Jerzy Trojan and Ignacio Briceno


Open access peer-reviewed

6. Using REMBRANDT to Paint in the Details of Glioma Biology: Applications for Future Immunotherapy

By An Q. Dang, Neil T. Hoa, Lisheng Ge, Gabriel Arismendi Morillo, Brian Paleo, Esteban J. Gomez, Dayeon Judy Shon, Erin Hong, Ahmed M. Aref and Martin R. Jadus


Open access peer-reviewed

7. From Gliomagenesis to Multimodal Therapeutic Approaches into High-Grade Glioma Treatment

By Giuseppe Raudino, Maria Caffo, Gerardo Caruso, Concetta Alafaci, Federica Raudino, Valentina Marventano, Alberto Romano, Francesco Montemagno, Massimo Belvedere, Francesco Maria Salpietro, Francesco Tomasello and Anna Schillaci


Open access peer-reviewed

8. Dipeptidyl Peptidase-IV and Related Proteases in Brain Tumors

By Petr Busek and Aleksi Sedo


Open access peer-reviewed

9. Apoptotic Events in Glioma Activate Metalloproteinases and Enhance Invasiveness

By Albert Magro


Open access peer-reviewed

10. The Distribution and Significance of IDH Mutations in Gliomas

By Marta Mellai, Valentina Caldera, Laura Annovazzi and Davide Schiffer


Open access peer-reviewed

11. Deregulation of Cell Polarity Proteins in Gliomagenesis

By Khamushavalli Geevimaan and Phanithi Prakash Babu


Open access peer-reviewed

12. Aquaporin, Midkine and Glioblastoma

By Mine Ergüven


Open access peer-reviewed

13. Porphyrin Synthesis from 5-Aminolevulinic Acid in Patients with Glioma

By Satoshi Utsuki, Hidehiro Oka, Kiyotaka Fujii, Norio Miyoshi, Masahiro Ishizuka, Kiwamu Takahashi and Katsushi Inoue


Open access peer-reviewed

14. Mechanisms of Aggressiveness in Glioblastoma: Prognostic and Potential Therapeutic Insights

By Céline S. Gonçalves, Tatiana Lourenço, Ana Xavier-Magalhães, Marta Pojo and Bruno M. Costa


Open access peer-reviewed

15. A Rational for Novel Anti-NeuroOncology Drugs

By Lee Roy Morgan


Open access peer-reviewed

16. DNA-PK is a Potential Molecular Therapeutic Target for Glioblastoma

By P. O. Carminati, F. S. Donaires, P. R. D. V. Godoy, A. P. Montaldi, J. A. Meador, A.S. Balajee, G. A. Passos and E. T. Sakamoto-Hojo


Open access peer-reviewed

17. Evolvement of microRNAs as Therapeutic Targets for Malignant Gliomas

By Sihan Wu, Wenbo Zhu and Guangmei Yan


Open access peer-reviewed

18. MicroRNAs Regulated Brain Tumor Cell Phenotype and Their Therapeutic Potential

By Chunzhi Zhang, Budong Chen, Xiangying Xu, Baolin Han, Guangshun Wang and Jinhuan Wang


Open access peer-reviewed

19. Carbonic Anhydrase IX in Adult and Pediatric Brain Tumors

By Kristiina Nordfors, Joonas Haapasalo, Hannu Haapasalo and Seppo Parkkila


Open access peer-reviewed

20. New Molecular Targets and Treatments for Pediatric Brain Tumors

By Claudia C. Faria, Christian A. Smith and James T. Rutka


Open access peer-reviewed

21. In silico Analysis of Transcription Factors Associated to Differentially Expressed Genes in Irradiated Glioblastoma Cell Lines

By P. R. D. V. Godoy, S. S. Mello, F. S. Donaires, E. A. Donadi, G. A. S. Passos and E. T. Sakamoto-Hojo


Open access peer-reviewed

22. Brain Tumor Stemness

By Andrés Felipe Cardona and León Darío Ortíz


Open access peer-reviewed

23. Nestin: Neural Stem/Progenitor Cell Marker in Brain Tumors

By Yoko Matsuda, Hisashi Yoshimura, Taeko Suzuki and Toshiyuki Ishiwata


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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