Open access peer-reviewed Edited Volume

Molecular Targets of CNS Tumors

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Academic Editor

Miklos Garami

Semmelweis University, Hungary

PublishedSeptember 22nd, 2011

Doi10.5772/1047

ISBN978-953-307-736-9

eBook (PDF) ISBN978-953-51-6496-8

Copyright year2011

Number of pages688

Molecular Targets of CNS Tumors is a selected review of Central Nervous System (CNS) tumors with particular emphasis on signaling pathway of the most common CNS tumor types. To develop drugs which specifically attack the cancer cells requires an understanding of the distinct characteristics of those cells. Additional detailed information is provided on selected signal pathways in CNS tumors.

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Table of Contents

Open access peer-reviewed  chapters

1. Genetic and Immunology of Brain Tumors

By Sahika Liva Cengiz and Aynur Emine Cicekcibasi

2,168
2. Genetic Instability in Paediatric and Adult Brain Tumours

By Marta Viana-Pereira, Chris Jones and Rui M. Reis

1,853
8. Glioma Stem Cells

By Kouichi Tabu, Tetsuya Taga and Shinya Tanaka

2,105
9. Molecular Hallmarks of Gliomas

By Marta Pojo and Bruno Marques Costa

1,590
2
12. Portrait of Transcriptional Expression Profiles Displayed by Different Glioblastoma Cell Lines

By Paulo R. D. V. Godoy, Stephano S. Mello, Daniele A. Magalhães, Flavia S. Donaires, Ana P. Lima-Montaldi, Patricia Nicolucci, Eduardo A. Donadi, Geraldo A. S. Passos and Elza T. Sakamoto-Hojo

1,763
13. Genetics and Biology of Glioblastoma Multiforme

By Anália Carmo, Inês Crespo and Maria Celeste Lopes

2,271
2
14. Chemokines in Glioma Progression

By Marco Locatelli and Alberto Mantovani

2,628
15. Biomarkers of Glioma

By Shufang Liang and Guobo Shen

3,199
3
17. MicroRNA in Human Gliomas

By Alfredo Conti, Lucia Merlo, Domenico La Torre and M’Hammed Aguennouz

1,429
18. Gliomas: Role of Wnt/β-Catenin/Tcf Signaling Pathway

By Gangadhara Reddy Sareddy and Phanithi Prakash Babu

1,649
4,215
1
21. The Expression of BORIS Protein in a Newly Established Primary Glioma Cell Culture Line

By Siti Zawani Mohd Ramli, Shaharum Shamsuddin, Nik Norliza Hassan, Azmi Alias, Mohd Saffari Mohd Haspani and Jafri Abdullah

2,076
22. MiR-221/222 Promote the Growth of Malignant Glioma Cells by Regulating Its Target Genes

By Zhang Chunzhi, Jiang Tao, Wang Jinhuan, Cheng Jinquan, Pu Peiyu and Kang Chunsheng

2,836
23. Primary Glioblastoma with Different Patterns of EGFR Amplification and the Relationship with Gene Expression Profile

By Concha Lopez-Gines, Rosario Gil-Benso, Daniel Monleon, Jose Gonzalez-Darder and Miguel Cerda-Nicolas

2,717
1
24. Nuclear Signaling of EGFR and EGFRvIII in Glioblastoma

By Anupama E. Gururaj, Oliver Bögler and Khatri Latha

3,226
25. Ap 1 in Glioblastomas

By Densie Smith and Bruce Bejcek

1,346
26. The Musashi1 RNA-Binding Protein: A Critical Regulator in Glioblastoma

By Dat T. Vo, Devraj Sandhu, Jonathan A. Gelfond and Luiz O. Penalva

1,686
27. The Pivotal Roles of GSK3β in Glioma Biology

By Mitsutoshi Nakada, Toshinari Minamoto, Ilya V. Pyko, Yutaka Hayashi and Jun-ichiro Hamada

4,256
5
28. The Role of Matrix Metalloproteinases a nd Tissue Inhibitors of Metalloproteinases in the Progression of Astrocytomas

By Fábio Motta, Renata Canalle, France Yoshioka, Giovanny Pinto, Lúcia Harada, Carlotti Jurnior, Elvis Valera, Carlos Scrideli and Luiz Tone

1,711
29. Medulloblastoma – Genetic Alterations

By Esther Manor and Lipa Bodner

1,675
30. The Role of HGF/c-Met Pathway Signaling in Human Medulloblastoma

By Claudia Faria, Christian Smith and James Rutka

4,400
2

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78,632 Total Chapter Downloads

19 Crossref Citations

58 Web of Science Citations

69 Dimensions Citations

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