Open access peer-reviewed Edited Volume

Ubiquitin Proteasome System

Current Insights into Mechanism Cellular Regulation and Disease

Edited by Matthew Summers

The Ohio State University

The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

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Ubiquitin Proteasome SystemCurrent Insights into Mechanism Cellular Regulation and DiseaseEdited by Matthew Summers

Published: June 19th 2019

DOI: 10.5772/intechopen.78430

ISBN: 978-1-83880-491-6

Print ISBN: 978-1-83880-490-9

eBook (PDF) ISBN: 978-1-83880-717-7

Copyright year: 2019

Books open for chapter submissions

6356 Total Chapter Downloads

6 Crossref Citations

2 Web of Science Citations

12 Dimensions Citations


Open access peer-reviewed

1. Ubiquitin Signaling in Regulation of the Start of the Cell Cycle

By Michael James Emanuele and Taylor Paige Enrico


Open access peer-reviewed

2. Processes that Regulate the Ubiquitination of Chromatin and Chromatin-Associated Proteins

By Alexander E. Hare and Jeffrey D. Parvin


Open access peer-reviewed

3. E3 Ubiquitin Ligases in Cancer and Their Pharmacological Targeting

By Joseph Y. Ong and Jorge Z. Torres


Open access peer-reviewed

4. The Role of Lysine 63-Linked Ubiquitylation in Health and Disease

By Paola Pontrelli, Francesca Conserva and Loreto Gesualdo


Open access peer-reviewed

5. Regulation of Selective Proteolysis in Cancer

By Pai-Sheng Chen


Open access peer-reviewed

6. Ubiquitin Carboxyl-Terminal Hydrolase L1 in Parkinson’s Disease

By Dang Thi Phuong Thao


Open access peer-reviewed

7. New Insights into the Mechanisms Underlying NEDD8 Structural and Functional Specificities

By Elena Santonico


Open access peer-reviewed

8. ADP-Ribosylation of the Ubiquitin C-Terminus by Dtx3L/Parp9

By Teddy Kamata and Bryce Paschal


Open access peer-reviewed

9. Structural Insight into Regulation of the Proteasome Ub-Receptor Rpn10

By Tal Keren-Kaplan, Ilan Attali, Olga Levin-Kravets, Oded Kleifeld, Shay Ben-Aroya and Gali Prag


Open access peer-reviewed

10. Zinc-Binding B-Box Domains with RING Folds Serve Critical Roles in the Protein Ubiquitination Pathways in Plants and Animals

By Michael Anthony Massiah


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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