Open access peer-reviewed Edited Volume


Concept and Applications in Medical Sciences

Edited by Xianquan Zhan

Shandong First Medical University

A proteoform is the basic unit in a proteome, defined as its amino acid sequence + post-translational modifications + spatial conformation + localization + cofactors + binding partners + a function, which is the final functional performer of a gene. Studies on proteoforms offer in-depth insights and can lead to the discovery of reliable biomarkers and therapeutic targets for effective prediction, diagnosis, prognostic assessment, and therapy of disease. This book focuses on the concept, study, and applications of proteoforms. Chapters cover such topics as methodologies for identifying and preparing proteoforms, proteoform pattern alteration in pituitary adenomas, and proteoforms in leukemia.

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ProteoformsConcept and Applications in Medical SciencesEdited by Xianquan Zhan

Published: July 15th 2020

DOI: 10.5772/intechopen.83687

ISBN: 978-1-83880-034-5

Print ISBN: 978-1-83880-033-8

eBook (PDF) ISBN: 978-1-83962-832-0

Copyright year: 2020

Books open for chapter submissions

1833 Total Chapter Downloads

1 Crossref Citations

1 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Proteoforms

By Xianquan Zhan


Open access peer-reviewed

2. Proteoforms: General Concepts and Methodological Process for Identification

By Jucélia da Silva Araújo and Olga Lima Tavares Machado


Open access peer-reviewed

3. Preparing Proteoforms of Therapeutic Proteins for Top-Down Mass Spectrometry

By Siti Nurul Hidayah, Manasi Gaikwad, Laura Heikaus and Hartmut Schlüter


Open access peer-reviewed

4. Prolactin Proteoform Pattern Changed in Human Pituitary Adenoma Relative to Control Pituitary Tissues

By Xianquan Zhan and Shehua Qian


Open access peer-reviewed

5. Proteoforms in Acute Leukemia: Evaluation of Age- and Disease-Specific Proteoform Patterns

By Fieke W. Hoff, Anneke D. van Dijk and Steven M. Kornblau


Edited Volume and chapters are indexed in

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  • CNKI

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