Open access peer-reviewed Edited Volume


Proteasome Pathway

Edited by Xianquan Zhan

Shandong First Medical University

The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases.

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UbiquitinProteasome PathwayEdited by Xianquan Zhan

Published: December 9th 2020

DOI: 10.5772/intechopen.87547

ISBN: 978-1-83880-841-9

Print ISBN: 978-1-83880-432-9

eBook (PDF) ISBN: 978-1-83880-842-6

Copyright year: 2020

Books open for chapter submissions

1670 Total Chapter Downloads

1 Crossref Citations

1 Dimensions Citations


Open access peer-reviewed

1. Branching and Mixing: New Signals of the Ubiquitin Signaling System

By Daniel Perez-Hernandez, Marta L. Mendes and Gunnar Dittmar


Open access peer-reviewed

2. Ubiquitin-Independent Proteasomal Degradation Mediated by Antizyme

By Noriyuki Murai


Open access peer-reviewed

3. Lys63-Linked Polyubiquitination of Transforming Growth Factor β Type I Receptor (TβRI) Specifies Oncogenic Signaling

By Jie Song and Maréne Landström


Open access peer-reviewed

4. Ubiquitination and Deubiquitination in Melanoma Research and Clinically Relevant Outcomes

By Jia Guo and Jianglin Zhang


Open access peer-reviewed

5. New Discoveries on the Roles of “Other” HECT E3 Ubiquitin Ligases in Disease Development

By Emma I. Kane and Donald E. Spratt


Open access peer-reviewed

6. Abnormal Ubiquitination of Ubiquitin-Proteasome System in Lung Squamous Cell Carcinomas

By Xianquan Zhan and Miaolong Lu


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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