Matthew Summers

The Ohio State University United States of America

Matthew Summers received a Bachelor’s of Science degree in Biochemistry in 1997 from the University of Delaware. He then pursued his thesis work at the Wistar Institute and received a Ph.D. in Cell and Molecular Biology from the University of Pennsylvania in 2003. From 2004-2009 he performepostdoctoralal research at Stanford University and Genentech. In 2009, he joined the faculty at the Cleveland Clinic Lerner Research Institute as Assistant Staff. In 2015 he joined the Ohio State University and James Comprehensive Cancer Center as an Associate Professor. Research in the Summers lab focuses on the interplay between cellular checkpoints and the ubiquitin-proteasome system to regulate genome stability.

Matthew Summers

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Latest work with IntechOpen by Matthew Summers

The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

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