Open access peer-reviewed Edited Volume

Ubiquitination Governing DNA Repair

Implications in Health and Disease

Edited by Effrossyni Boutou

Laiko General Hospital of Athens, Greece


DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in many cases as recruitment platforms for DNA repair mechanisms by facilitating binding sites or regulating interactions between involved proteins. Ubiquitination, the addition of ubiquitin moieties on a target protein, apart from controlling protein availability through degradation, is also involved, together with partner small ubiquitin-like modifier (SUMO), in controlling many pathways involved in DDR by modifying the structure-function relationship and thus interacting with partner molecules. The aim of this book is to cover a broad spectrum of current topics in ubiquitination and to a lesser extent SUMOylation involvement in regulation of DDR and repair in health and disease. This book is intended for pre- and postgraduate students and young scientists in this field. Members of both academic and research institutions, actively involved in the field, have described their current understanding of major mechanisms involved, highlighted key events, described ongoing applications in both developmental diseases and cancer and provided hints for future potential applications.

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Ubiquitination Governing DNA RepairImplications in Health and DiseaseEdited by Effrossyni Boutou

Published: August 1st 2018

DOI: 10.5772/66565

ISBN: 978-1-78923-585-2

Print ISBN: 978-1-78923-584-5

eBook (PDF) ISBN: 978-1-83881-264-5

Copyright year: 2018

Books open for chapter submissions

9778 Total Chapter Downloads

2 Crossref Citations

3 Web of Science Citations

6 Dimensions Citations


Open access peer-reviewed

1. Ubiquitylation and SUMOylation: An Orchestrated Regulation During DNA Damage Repair

By Sara Espinoza-Corona, Ma Luisa Bazán-Tejeda, Ulises Omar García- Lepe and Rosa Ma Bermúdez-Cruz


Open access peer-reviewed

2. The Five Families of DNA Repair Proteins and their Functionally Relevant Ubiquitination

By Niko Moses and Xiaohong Mary Zhang


Open access peer-reviewed

3. Regulation of the Base Excision Repair Pathway by Ubiquitination

By Rachel Jane Carter and Jason Luke Parsons


Open access peer-reviewed

4. The Role of Deubiquitinases in DNA Double-Strand Break Repair

By Jun Lu, Zhi-Feng Xi, Xiao-Ying Huang, Qiang Xia and Xi-Dai Long


Open access peer-reviewed

5. The Roles of Cullin RING Ligases and the Anaphase Promoting Complex/Cyclosome in the Regulation of DNA Double Strand Break Repair

By Debjani Pal and Matthew K. Summers


Open access peer-reviewed

6. The Cross Talk among Autophagy, Ubiquitination, and DNA Repair: An Overview

By Francesca Nazio, Emiliano Maiani and Francesco Cecconi


Open access peer-reviewed

7. Interlace between Chromatin Structure, DNA Repair and Ubiquitination

By Attya Bhatti, Shanzay Ahmed, Arooma Jannat and Peter John


Open access peer-reviewed

8. Maintenance of Genome Stability by Ubiquitination of DNA Repair Proteins in Mammalian Development and Disease

By Mikio Shimada


Open access peer-reviewed

9. Ubiquitination and DNA Repair in Multiple Myeloma

By Lisa J. Crawford and Alexandra E. Irvine


Open access peer-reviewed

10. Ubiquitin and Fanconi Anemia

By Ioannis Drikos and Alexandros Sachinidis


Open access peer-reviewed

11. Review of the Ubiquitin Role in DNA Repair and Tumorigenesis, with Emphasis in Breast Cancer Treatment; Current Data and Future Options

By Despoina Mourtzoukou, Ioannis Drikos, Nikolaos Goutas and Dimitris Vlachodimitropoulos


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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