Open access peer-reviewed Edited Volume

Type 1 Diabetes

Pathogenesis, Genetics and Immunotherapy

Edited by David Wagner

University of Denver, United States of America

This book is a compilation of reviews about the pathogenesis of Type 1 Diabetes. T1D is a classic autoimmune disease. Genetic factors are clearly determinant but cannot explain the rapid, even overwhelming expanse of this disease. Understanding etiology and pathogenesis of this disease is essential. A number of experts in the field have covered a range of topics for consideration that are applicable to researcher and clinician alike. This book provides apt descriptions of cutting edge technologies and applications in the ever going search for treatments and cure for diabetes. Areas including T cell development, innate immune responses, imaging of pancreata, potential viral initiators, etc. are considered.

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Type 1 DiabetesPathogenesis, Genetics and ImmunotherapyEdited by David Wagner

Published: November 25th 2011

DOI: 10.5772/866

ISBN: 978-953-307-362-0

eBook (PDF) ISBN: 978-953-51-6585-9

Copyright year: 2011

Books open for chapter submissions

53858 Total Chapter Downloads

17 Crossref Citations

19 Web of Science Citations

26 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Autoimmunity and Immunotherapy of Type 1 Diabetes

By Mourad Aribi

2247

Open access peer-reviewed

2. Use of Congenic Mouse Strains for Gene Identification in Type 1 Diabetes

By Ute Christine Rogner

1389

Open access peer-reviewed

3. Relationship of Type 1 Diabetes with Human Leukocyte Antigen (HLA) Class II Antigens Except for DR3 and DR4

By Masahito Katahira

1910

Open access peer-reviewed

4. The Role of T Cells in Type 1 Diabetes

By David Wagner

3151

Open access peer-reviewed

5. Beta-Cell Function and Failure in Type 1 Diabetes

By Maria-Luisa Lazo de la Vega-Monroy and Cristina Fernandez-Mejia

5627

Open access peer-reviewed

6. Steady-State Cell Apoptosis and Immune Tolerance - Induction of Tolerance Using Apoptotic Cells in Type 1 Diabetes and Other Immune-Mediated Disorders

By Chang-Qing Xia, Kim Campbell, Benjamin Keselowsky and Michael Clare-Salzler

1314

Open access peer-reviewed

7. Innate Immunity in the Recognition of β-Cell Antigens in Type 1 Diabetes

By Jixin Zhong, Jun-Fa Xu, Ping Yang, Yi Liang and Cong-Yi Wang

1843

Open access peer-reviewed

8. The Role of Reg Proteins, a Family of Secreted C-Type Lectins, in Islet Regeneration and as Autoantigens in Type 1 Diabetes

By Werner Gurr

1597

Open access peer-reviewed

9. Type I Diabetes and the Role of Inflammatory-Related Cellular Signaling

By Lloyd Jesse, Kelleher Andrew, Choi Myung and Keslacy Stefan

1303

Open access peer-reviewed

10. Echovirus Epidemics, Autoimmunity, and Type 1 Diabetes

By Oscar Diaz-Horta, Luis Sarmiento, Andreina Baj, Eduardo Cabrera-Rode and Antonio Toniolo

1211

Open access peer-reviewed

11. Environmental Triggers of Type 1 Diabetes Mellitus – Mycobacterium Avium Subspecies Paratuberculosis

By Coad Thomas Dow and Leonardo A. Sechi

1720

Open access peer-reviewed

12. In Vivo Monitoring of Inflammation and Regulation in Type 1 Diabetes

By Mi-Heon Lee, Sonya Liu, Wen-Hui Lee and Chih-Pin Liu

1295

Open access peer-reviewed

13. Imaging the Pancreatic Beta Cell

By Ulf Ahlgren and Elena Kostromina

2593

Open access peer-reviewed

14. Present Accomplishments and Future Prospects of Cell-Based Therapies for Type 1 Diabetes Mellitus

By Preeti Chhabra, Clark D. Kensinger, Daniel J. Moore and Kenneth L. Brayman

1415

Open access peer-reviewed

15. Peptides and Proteins for Treatment and Suppression of Type 1 Diabetes

By Ahmed H. Badawi, Barlas Büyüktimkin, Paul Kiptoo and Teruna J. Siahaan

1175

Open access peer-reviewed

16. Immunotherapy for Type 1 Diabetes – Preclinical and Clinical Trials

By Alice Li and Alan Escher

2229

Open access peer-reviewed

17. Type 1 Diabetes Immunotherapy - Successes, Failures and Promises

By Brett E. Phillips and Nick Giannoukakis

1375

Open access peer-reviewed

18. Immunotherapy for Type 1 Diabetes - Necessity, Challenges and Unconventional Opportunities

By Rachel Gutfreund and Abdel Rahim A. Hamad

1226

Open access peer-reviewed

19. Autoantigen-Specific Immunotherapy

By Shuhong Han, William Donelan, Westley Reeves and Li-Jun Yang

1651

Open access peer-reviewed

20. Multi-Component Vaccines for Suppression of Type 1 Diabetes

By William H.R. Langridge and Oludare J. Odumosu

1243

Open access peer-reviewed

21. Porcine Islet Xenotransplantation for the Treatment of Type 1 Diabetes

By Dana Mihalicz, Ray V. Rajotte and Gina R. Rayat

2113

Open access peer-reviewed

22. Beta Cell Replacement Therapy

By Jeffrey A. SoRelle and Bashoo Naziruddin

2105

Open access peer-reviewed

23. Genetics of Type 1 Diabetes

By Tatijana Zemunik and Vesna Boraska

2629

Open access peer-reviewed

24. The Genetics of Type 1 Diabetes

By Kathleen M. Gillespie

2422

Open access peer-reviewed

25. Comparative Genetic Analysis of Type 1 Diabetes and Inflammatory Bowel Disease

By Marina Bakay, Rahul Pandey and Hakon Hakonarson

1966

Open access peer-reviewed

26. Genetics of Type 1 Diabetes

By Marie Cerna

1067

Open access peer-reviewed

27. Genetic Markers, Serological Auto Antibodies and Prediction of Type 1 Diabetes

By Raouia Fakhfakh

2331

Open access peer-reviewed

28. Genetic Determinants of Type 1 Diabetes

By Mohamed M. Jahromi

1714

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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