Open access peer-reviewed Edited Volume

Type 1 Diabetes

Pathogenesis, Genetics and Immunotherapy

Edited by David Wagner

University of Denver, United States of America

This book is a compilation of reviews about the pathogenesis of Type 1 Diabetes. T1D is a classic autoimmune disease. Genetic factors are clearly determinant but cannot explain the rapid, even overwhelming expanse of this disease. Understanding etiology and pathogenesis of this disease is essential. A number of experts in the field have covered a range of topics for consideration that are applicable to researcher and clinician alike. This book provides apt descriptions of cutting edge technologies and applications in the ever going search for treatments and cure for diabetes. Areas including T cell development, innate immune responses, imaging of pancreata, potential viral initiators, etc. are considered.

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Type 1 DiabetesPathogenesis, Genetics and ImmunotherapyEdited by David Wagner

Published: November 25th 2011

DOI: 10.5772/866

ISBN: 978-953-307-362-0

eBook (PDF) ISBN: 978-953-51-6585-9

Copyright year: 2011

Books open for chapter submissions

69828 Total Chapter Downloads

20 Crossref Citations

20 Web of Science Citations

30 Dimensions Citations


Open access peer-reviewed

1. Autoimmunity and Immunotherapy of Type 1 Diabetes

By Mourad Aribi


Open access peer-reviewed

2. Use of Congenic Mouse Strains for Gene Identification in Type 1 Diabetes

By Ute Christine Rogner


Open access peer-reviewed

3. Relationship of Type 1 Diabetes with Human Leukocyte Antigen (HLA) Class II Antigens Except for DR3 and DR4

By Masahito Katahira


Open access peer-reviewed

4. The Role of T Cells in Type 1 Diabetes

By David Wagner


Open access peer-reviewed

5. Beta-Cell Function and Failure in Type 1 Diabetes

By Maria-Luisa Lazo de la Vega-Monroy and Cristina Fernandez-Mejia


Open access peer-reviewed

6. Steady-State Cell Apoptosis and Immune Tolerance - Induction of Tolerance Using Apoptotic Cells in Type 1 Diabetes and Other Immune-Mediated Disorders

By Chang-Qing Xia, Kim Campbell, Benjamin Keselowsky and Michael Clare-Salzler


Open access peer-reviewed

7. Innate Immunity in the Recognition of β-Cell Antigens in Type 1 Diabetes

By Jixin Zhong, Jun-Fa Xu, Ping Yang, Yi Liang and Cong-Yi Wang


Open access peer-reviewed

8. The Role of Reg Proteins, a Family of Secreted C-Type Lectins, in Islet Regeneration and as Autoantigens in Type 1 Diabetes

By Werner Gurr


Open access peer-reviewed

9. Type I Diabetes and the Role of Inflammatory-Related Cellular Signaling

By Lloyd Jesse, Kelleher Andrew, Choi Myung and Keslacy Stefan


Open access peer-reviewed

10. Echovirus Epidemics, Autoimmunity, and Type 1 Diabetes

By Oscar Diaz-Horta, Luis Sarmiento, Andreina Baj, Eduardo Cabrera-Rode and Antonio Toniolo


Open access peer-reviewed

11. Environmental Triggers of Type 1 Diabetes Mellitus – Mycobacterium Avium Subspecies Paratuberculosis

By Coad Thomas Dow and Leonardo A. Sechi


Open access peer-reviewed

12. In Vivo Monitoring of Inflammation and Regulation in Type 1 Diabetes

By Mi-Heon Lee, Sonya Liu, Wen-Hui Lee and Chih-Pin Liu


Open access peer-reviewed

13. Imaging the Pancreatic Beta Cell

By Ulf Ahlgren and Elena Kostromina


Open access peer-reviewed

14. Present Accomplishments and Future Prospects of Cell-Based Therapies for Type 1 Diabetes Mellitus

By Preeti Chhabra, Clark D. Kensinger, Daniel J. Moore and Kenneth L. Brayman


Open access peer-reviewed

15. Peptides and Proteins for Treatment and Suppression of Type 1 Diabetes

By Ahmed H. Badawi, Barlas Büyüktimkin, Paul Kiptoo and Teruna J. Siahaan


Open access peer-reviewed

16. Immunotherapy for Type 1 Diabetes – Preclinical and Clinical Trials

By Alice Li and Alan Escher


Open access peer-reviewed

17. Type 1 Diabetes Immunotherapy - Successes, Failures and Promises

By Brett E. Phillips and Nick Giannoukakis


Open access peer-reviewed

18. Immunotherapy for Type 1 Diabetes - Necessity, Challenges and Unconventional Opportunities

By Rachel Gutfreund and Abdel Rahim A. Hamad


Open access peer-reviewed

19. Autoantigen-Specific Immunotherapy

By Shuhong Han, William Donelan, Westley Reeves and Li-Jun Yang


Open access peer-reviewed

20. Multi-Component Vaccines for Suppression of Type 1 Diabetes

By William H.R. Langridge and Oludare J. Odumosu


Open access peer-reviewed

21. Porcine Islet Xenotransplantation for the Treatment of Type 1 Diabetes

By Dana Mihalicz, Ray V. Rajotte and Gina R. Rayat


Open access peer-reviewed

22. Beta Cell Replacement Therapy

By Jeffrey A. SoRelle and Bashoo Naziruddin


Open access peer-reviewed

23. Genetics of Type 1 Diabetes

By Tatijana Zemunik and Vesna Boraska


Open access peer-reviewed

24. The Genetics of Type 1 Diabetes

By Kathleen M. Gillespie


Open access peer-reviewed

25. Comparative Genetic Analysis of Type 1 Diabetes and Inflammatory Bowel Disease

By Marina Bakay, Rahul Pandey and Hakon Hakonarson


Open access peer-reviewed

26. Genetics of Type 1 Diabetes

By Marie Cerna


Open access peer-reviewed

27. Genetic Markers, Serological Auto Antibodies and Prediction of Type 1 Diabetes

By Raouia Fakhfakh


Open access peer-reviewed

28. Genetic Determinants of Type 1 Diabetes

By Mohamed M. Jahromi


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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