Open access peer-reviewed Edited Volume

Proteoforms

Concept and Applications in Medical Sciences

Edited by Xianquan Zhan

Shandong First Medical University

A proteoform is the basic unit in a proteome, defined as its amino acid sequence + post-translational modifications + spatial conformation + localization + cofactors + binding partners + a function, which is the final functional performer of a gene. Studies on proteoforms offer in-depth insights and can lead to the discovery of reliable biomarkers and therapeutic targets for effective prediction, diagnosis, prognostic assessment, and therapy of disease. This book focuses on the concept, study, and applications of proteoforms. Chapters cover such topics as methodologies for identifying and preparing proteoforms, proteoform pattern alteration in pituitary adenomas, and proteoforms in leukemia.

Read more >Order hardcopy
IntechOpen
ProteoformsConcept and Applications in Medical SciencesEdited by Xianquan Zhan

Published: July 15th 2020

DOI: 10.5772/intechopen.83687

ISBN: 978-1-83880-034-5

Print ISBN: 978-1-83880-033-8

eBook (PDF) ISBN: 978-1-83962-832-0

Copyright year: 2020

Books open for chapter submissions

363 Total Chapter Downloads

chaptersDownloads

Open access peer-reviewed

1. Introductory Chapter: Proteoforms

By Xianquan Zhan

41

Open access peer-reviewed

2. Proteoforms: General Concepts and Methodological Process for Identification

By Jucélia da Silva Araújo and Olga Lima Tavares Machado

101

Open access peer-reviewed

3. Preparing Proteoforms of Therapeutic Proteins for Top-Down Mass Spectrometry

By Siti Nurul Hidayah, Manasi Gaikwad, Laura Heikaus and Hartmut Schlüter

112

Open access peer-reviewed

4. Prolactin Proteoform Pattern Changed in Human Pituitary Adenoma Relative to Control Pituitary Tissues

By Xianquan Zhan and Shehua Qian

46

Open access peer-reviewed

5. Proteoforms in Acute Leukemia: Evaluation of Age- and Disease-Specific Proteoform Patterns

By Fieke W. Hoff, Anneke D. van Dijk and Steven M. Kornblau

63

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£140

Order now

Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase