Open access peer-reviewed Edited Volume

Human Skin Cancers

Pathways, Mechanisms, Targets and Treatments

Edited by Miroslav Blumenberg

New York University Medical School

Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.

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Human Skin CancersPathways, Mechanisms, Targets and TreatmentsEdited by Miroslav Blumenberg

Published: May 2nd 2018

DOI: 10.5772/68061

ISBN: 978-1-78923-095-6

Print ISBN: 978-1-78923-094-9

Copyright year: 2018

Books open for chapter submissions

549 Total Chapter Downloads

chaptersDownloads

Open access peer-reviewed

1. Epigenetics in Melanoma Development and Drug Resistance

By Heinz Hammerlindl and Helmut Schaider

84

Open access peer-reviewed

2. LncRNAs as Biomarkers for Melanoma

By Yixuan James Zheng, Ricardo Moreno Traspas and Susana Ortiz- Urda

71

Open access peer-reviewed

3. The Multiple Roles of Tyrosinase-Related Protein-2/L- Dopachrome Tautomerase in Melanoma: Biomarker, Therapeutic Target, and Molecular Driver in Tumor Progression

By Adina L. Milac and Gabriela Negroiu

96

Open access peer-reviewed

4. The Modern Approach to Targeting Melanoma

By Jane O'Sullivan and Donal O’Connor

70

Open access peer-reviewed

5. Possibilities for the Therapy of Melanoma: Current Knowledge and Future Directions

By Marcela Valko-Rokytovská, Jana Šimková, Mária Milkovičová and Zuzana Kostecká

56

Open access peer-reviewed

6. Squamous Cell Carcinoma: Biomarkers and Potential Therapeutic Targets

By Vlad-Mihai Voiculescu, Constantin Caruntu, Iulia Solomon, Mihai Lupu, Mihaela Adriana Ilie, Daniel Boda, Carolina Constantin and Monica Neagu

64

Open access peer-reviewed

7. Correlation between Porcine and Human Skin Models by Optical Methods

By Alessandra Keiko Lima Fujita, Rozana Wendler da Rocha, André Escobar, Andrigo Barboza de Nardi, Vanderlei Salvador Bagnato and Priscila Fernanda Campos de Menezes

46

Open access peer-reviewed

8. Molecular Mechanisms and Biomarkers of Skin Photocarcinogenesis

By Adriana T. Lopez, Liang Liu and Larisa Geskin

62

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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